Conserved Protein Domain Family
STKc_MEKK2

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cd06652: STKc_MEKK2 (this model, PSSM-Id:132983 is obsolete and has been replaced by 270818)
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 2
Serine/threonine kinases (STKs), MAP/ERK kinase kinase 2 (MEKK2) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MEKK2 is a mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK or MKKK or MAP3K), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates extracellular signal-regulated kinase 5 (ERK5). The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling.
Statistics
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PSSM-Id: 132983
View PSSM: cd06652
Aligned: 3 rows
Threshold Bit Score: 573.52
Threshold Setting Gi: 47218565
Created: 29-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #####   #            # #                                 #             
gi 62297871  353 PTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPEtsKEVNALECEIQLLKNLlHERIVQYYGCLRDpqeKT 432
gi 118093793 357 PTNWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSPEtsKEVNALECEIQLLKNLlHERIVQYYGFLRDppeRT 436
gi 47218565  414 PTNWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPEtsKEVSALECEIQLLKNLcHERIVQYYGCLRDtmeRT 493
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ####                         ###  #                                   # ####
gi 62297871  433 LSIFMELSP------------------------GGSIKDQLKAYGaLTENVTRKYTRQILEGVHYLHsNMIVHRDIKGAN 488
gi 118093793 437 LSIFMEYMP------------------------GGSIKDQLKSYGaLTENVTRKYTRQILEGVLYLHtNMIVHRDIKGAN 492
gi 47218565  494 LSIFMEHMPgvsavgpgaaavreddaskrppslQGSIKDQLKSYGaLTEKVTRRYSRQILEGVSYLHsNMIVHRDIKGAN 573
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #         ### #                #### #                          #        #      
gi 62297871  489 ILRDstGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEgyGRKADIWSVACTVVEMLTeKPPWAEFEAMA 568
gi 118093793 493 ILRDsaGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEgyGRKADIWSVGCTVVEMLTeKPPWAEFEAMA 572
gi 47218565  574 ILRDsvGNVKLGDFGASRRLQTICLSGTGIMSVTGTPYWMSPEVISGEgyGRKADIWSVGCTVVEMLTqRPPWAEFEAMA 653
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                                                         
gi 62297871  569 AIFKIAtQPTNPKLPPHvsDYTRDFLKRIFVEAKLRPSAEELLRHMFVH 617
gi 118093793 573 AIFKIAtQPTNPQLPPHvsDHARDFLKRIFIEAKLRPFADELLRHTFAH 621
gi 47218565  654 AIFKIAtQPTNPVLPAHvsDHCREFLKRIFVETKQRPSADELLRHTFVH 702

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