Conserved Protein Domain Family
STKc_MEKK1_plant

?
cd06632: STKc_MEKK1_plant (this model, PSSM-Id:132963 is obsolete and has been replaced by 270802)
Catalytic domain of the Protein Serine/Threonine Kinase, Plant MAP/ERK kinase kinase 1
Serine/threonine kinases (STKs), plant MAP/ERK kinase kinase 1 (MEKK1)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of plant mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks) including Arabidopsis thaliana MEKK1 and MAPKKK3. MEKK1 is a MAPKKK that phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death.
Statistics
?
PSSM-Id: 132963
Aligned: 8 rows
Threshold Bit Score: 464.973
Threshold Setting Gi: 159483027
Created: 25-Aug-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #            # #                                        #        
NP_192590    332 SWQKGQLLGRGSFGSVYEGISg-dGDFFAVKEVSLldqgsq-------aqeciQQLEGEIKLLSQLqHQNIVRYRGTAKd 403 thale cress
NP_564635    213 TWKKGKFLGSGTFGQVYLGFNsekGKMCAIKEVKVisddqt-------skeclKQLNQEINLLNQLcHPNIVQYYGSELs 285 thale cress
XP_001772494  14 RWRKGELIGAGAYGRVYMGLNldsGELIAVKQVCIaqnnvtk----draqshiRELEEEVKLLQNLsHPNIVRYLGTARe 89  Physcomitrella ...
XP_001699564   3 RWRKGEGIGSGSFGQVYLALNcdtGDLLAVKEVPAglaggdgggaggggreavAQLEREVALLSALrHPNIVRYVGTQRs 82  Chlamydomonas r...
XP_001759137  14 RWKMGQLIGSGSFGSVYEGWNlddGSFFAVKVSSIdn--------------vsSEIHQEVAMLSKLkHPNIVQYYGTTTe 79  Physcomitrella ...
XP_001753280   2 KWQKGRLLGSGTFGNVYVGFNndnGGFCAMKEVLLvsddqk-------skesvKQLGQEISLLSKLrHENIVQYIGTETl 74  Physcomitrella ...
XP_001771274   1 TWAKGEFLGSGTFGSVYEGVAr-nGTFFAVKEVNLadegkl-------grqavKQLEREIALLSDIqHPNIVQYLGTERt 72  Physcomitrella ...
O22042        67 RWRKGELIGCGAFGRVYMGMNldsGELLAIKQVLIapssask----ektqghiRELEEEVQLLKNLsHPNIVRYLGTVRe 142 thale cress
Feature 1                         #### ###  #                                   # #### #         
NP_192590    404 g----------snLYIFLELVtQGSLLKLYQRYq-LRDSVVSLYTRQILDGLKYLHdKGFIHRDIKCANILVDanGAVKL 472 thale cress
NP_564635    286 e----------etLSVYLEYVsGGSIHKLLKDYgsFTEPVIQNYTRQILAGLAYLHgRNTVHRDIKGANILVDpnGEIKL 355 thale cress
XP_001772494  90 e----------eaLNIFLEFVpGGSIASLLGKFgsFTETVIRMYTRQLLLGLEYLHsNHIMHRDIKGANILVDnkGCIKL 159 Physcomitrella ...
XP_001699564  83 gagggggggggapLYIFLEYVpGGSLSSQLARFgpLPEPLVALYTRQLLLGLAYLHaQRTVHRDVKGANLLLEktGVLKL 162 Chlamydomonas r...
XP_001759137  80 d----------gnICIFLELVkMGSLEKIMKKFdaFDEVLIRLYTRQILKGLEYLHsRNTVHRDIKCANILVDsdGQVKL 149 Physcomitrella ...
XP_001753280  75 e----------drLYIYLEFVsGGSIHKLLQEYgaFKEPVVRNYTRQILSGLAYLHnQNTVHRDIKGANILVDtnGMVKL 144 Physcomitrella ...
XP_001771274  73 e----------dkLYIFLELLnKGSLANLYRKYg-LFYEQIKAYTEQILTGLKYLHdRKIIHRDIKCANILVDtnGVVKL 141 Physcomitrella ...
O22042       143 s----------dsLNILMEFVpGGSISSLLEKFgsFPEPVIIMYTKQLLLGLEYLHnNGIMHRDIKGANILVDnkGCIRL 212 thale cress
Feature 1        ### #                #### #                              #        #             
NP_192590    473 ADFGLAKVSKFNd-----IKSCKGTPFWMAPEVINRkds-dgyGSPADIWSLGCTVLEMCTGQIPYSDLe-pVQALFRIg 545 thale cress
NP_564635    356 ADFGMAKHVTAFs----tMLSFKGSPYWMAPEVVMSqn---gyTHAVDIWSLGCTILEMATSKPPWSQFe-gVAAIFKIg 427 thale cress
XP_001772494 160 ADFGASKKVVELati-seAKSMKGTPYWMAPEVIRQtg----hNWQADMWSVGCTVIEMATGKPPWSQQfqeVAALFHIg 234 Physcomitrella ...
XP_001699564 163 ADFGMAKQLMEQvs---fTRSFKGSAYWMAPEVIKQqg----yGVQADIWSVGCTVLEMATGKPPWSQCtsqVQAIFKIa 235 Chlamydomonas r...
XP_001759137 150 ADFGLAKQVLTFrtscsmASSVKGSPYYMAPEILAPqhskrpyGLPVDIWSLGCTVIEMADGKPPWGAFq-gYGFVFNVv 228 Physcomitrella ...
XP_001753280 145 ADFGMAKHISAQs----fLKSFKGSPYWMAPEVCVKcnp--syDLAVDIWSLGCTVLEMVTTKPPWHQYe-gVAAMFKIg 217 Physcomitrella ...
XP_001771274 142 ADFGMAKQVEKFg----fAKSFVGSAHWMAPEVVDPkq---qyNFAADIWSLGCTVLEMATEGPPFGELe-fIAVFWKIg 213 Physcomitrella ...
O22042       213 ADFGASKKVVELatv-ngAKSMKGTPYWMAPEVILQtg----hSFSADIWSVGCTVIEMATGKPPWSEQyqqFAAVLHIg 287 thale cress
Feature 1                                                   
NP_192590    546 r-gTLPEVPDTLSLDARLFILKCLKVnPEERPTAAELLNHPFV 587 thale cress
NP_564635    428 nskDTPEIPDHLSNDAKNFIRLCLQRnPTVRPTASQLLEHPFL 470 thale cress
XP_001772494 235 ttkSHPPIPEHLSADGKDFLLKLLQRePRLRPSAAEMLKHPFV 277 Physcomitrella patens subsp. patens
XP_001699564 236 sspDLPAIPDHLSPQASEFILLCLQRdPSSRPTAEELLRHPFV 278 Chlamydomonas reinhardtii
XP_001759137 229 k-gVLPPIPEHLSDKAKDFISQCLRKrPEDRPTVKELLLHPFV 270 Physcomitrella patens subsp. patens
XP_001753280 218 nskELPAIPDSLSREGRDFVRLCLQRdPAHRPTAAQLLEHPFV 260 Physcomitrella patens subsp. patens
XP_001771274 214 r-gEAPLIPDDLEDELKDFIAQCLQVdASKRPTCDMLLAHPFI 255 Physcomitrella patens subsp. patens
O22042       288 rtkAHPPIPEDLSPEAKDFLMKCLHKePSLRLSATELLQHPFV 330 thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap