Conserved Protein Domain Family
STKc_YSK4

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cd06631: STKc_YSK4 (this model, PSSM-Id:132962 is obsolete and has been replaced by 270801)
Catalytic domain of the Protein Serine/Threonine Kinase, Yeast Sps1/Ste20-related kinase 4
Serine/threonine kinases (STKs), yeast Sps1/Ste20-related kinase 4 (YSK4) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs (MKKKs or MAP3Ks) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.
Statistics
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PSSM-Id: 132962
Aligned: 3 rows
Threshold Bit Score: 531.794
Created: 22-Aug-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #           # #                                  #               
Q56UN5       1060 LWTKGEILGKGAYGTVYCGLTsqGQLIAVKQVALdtsnklaaekeYRKLQEEVDLLKALkHVNIVAYLGTCLqe--ntVS 1137 human
XP_001639884    4 EWQKGNVLGKGAFGTVFLGLVntGELIAVKQVELhpnnvdaaerqYEKLQEEVGLLKSLkHKNIVQYIGTCMddsqctIN 83   starlet sea a...
XP_426605    1013 MWTRGEVLGKGAYGTVYCGLTnqGQLIAVKQVVLdtsdqlttekeYQKLHEEVDLLKTLkHVNIVTYLGTCLed--niLS 1090 chicken
Feature 1           #### ###  #                                   # #### #         ### #          
Q56UN5       1138 IFMEFVpGGSISSIINRFGpLPEMVFCKYTKQILQGVAYLHeNCVVHRDIKGNNVMLMPtGIIKLIDFGCARRLAWAGLN 1217 human
XP_001639884   84 IFMEFVpGGSIAQALKRFGaFVEPVFRRYTRQILDGVSYLHnNNVIHRDIKGGNIMLMPnGVIKLIDFGCAKKICMVGAH 163  starlet sea a...
XP_426605    1091 IFMEFVpGGSISSILNRFGpLPEIVLCKYTKQILEGVAYLHdNCVVHRDIKGNNVMLMPnGIVKLIDFGCARRLAWVSLS 1170 chicken
Feature 1                  #### #                          #        #                             
Q56UN5       1218 GTHSDMLKSMHGTPYWMAPEVINESGyGRKSDIWSIGCTVFEMATGKPPLAsmdrmAAMFYIGahrgLMPPLPDHFSENA 1297 human
XP_001639884  164 VSKSNILRSMRGTPYWMAPEVIRETGhGRKSDIWSIGCTVFEMATGQPPWSnvpplSAIFAIGng-sPVPRLDESFSAAA 242  starlet sea a...
XP_426605    1171 GTHSEMLKSVHGTPYWMAPEVINESGyGRKSDIWSIGCTVFEMATGKPPLAsmdriAAMFYIGahrgLMPSLPDRFSGTA 1250 chicken
Feature 1                                    
Q56UN5       1298 ADFVRMCLTRDQHERPSALQLLKHSFL 1324 human
XP_001639884  243 IDFVTSCMTRDQDTRPSADELLRHDFL 269  starlet sea anemone
XP_426605    1251 VDFVHACLTRDQHERPSALQLLDHPFV 1277 chicken

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