Conserved Protein Domain Family
STKc_YSK4

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cd06631: STKc_YSK4 (this model, PSSM-Id:132962 is obsolete and has been replaced by 270801)
Catalytic domain of the Protein Serine/Threonine Kinase, Yeast Sps1/Ste20-related kinase 4
Serine/threonine kinases (STKs), yeast Sps1/Ste20-related kinase 4 (YSK4) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs (MKKKs or MAP3Ks) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.
Statistics
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PSSM-Id: 132962
View PSSM: cd06631
Aligned: 3 rows
Threshold Bit Score: 531.794
Threshold Setting Gi: 156403013
Created: 22-Aug-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #####   #           # #                                  #               
gi 74755104  1060 LWTKGEILGKGAYGTVYCGLTsqGQLIAVKQVALdtsnklaaekeYRKLQEEVDLLKALkHVNIVAYLGTCLqe--ntVS 1137
gi 156403013    4 EWQKGNVLGKGAFGTVFLGLVntGELIAVKQVELhpnnvdaaerqYEKLQEEVGLLKSLkHKNIVQYIGTCMddsqctIN 83
gi 118093896 1013 MWTRGEVLGKGAYGTVYCGLTnqGQLIAVKQVVLdtsdqlttekeYQKLHEEVDLLKTLkHVNIVTYLGTCLed--niLS 1090
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #### ###  #                                   # #### #         ### #          
gi 74755104  1138 IFMEFVpGGSISSIINRFGpLPEMVFCKYTKQILQGVAYLHeNCVVHRDIKGNNVMLMPtGIIKLIDFGCARRLAWAGLN 1217
gi 156403013   84 IFMEFVpGGSIAQALKRFGaFVEPVFRRYTRQILDGVSYLHnNNVIHRDIKGGNIMLMPnGVIKLIDFGCAKKICMVGAH 163
gi 118093896 1091 IFMEFVpGGSISSILNRFGpLPEIVLCKYTKQILEGVAYLHdNCVVHRDIKGNNVMLMPnGIVKLIDFGCARRLAWVSLS 1170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #### #                          #        #                             
gi 74755104  1218 GTHSDMLKSMHGTPYWMAPEVINESGyGRKSDIWSIGCTVFEMATGKPPLAsmdrmAAMFYIGahrgLMPPLPDHFSENA 1297
gi 156403013  164 VSKSNILRSMRGTPYWMAPEVIRETGhGRKSDIWSIGCTVFEMATGQPPWSnvpplSAIFAIGng-sPVPRLDESFSAAA 242
gi 118093896 1171 GTHSEMLKSVHGTPYWMAPEVINESGyGRKSDIWSIGCTVFEMATGKPPLAsmdriAAMFYIGahrgLMPSLPDRFSGTA 1250
                         250       260
                  ....*....|....*....|....*..
Feature 1                                    
gi 74755104  1298 ADFVRMCLTRDQHERPSALQLLKHSFL 1324
gi 156403013  243 IDFVTSCMTRDQDTRPSADELLRHDFL 269
gi 118093896 1251 VDFVHACLTRDQHERPSALQLLDHPFV 1277

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