Conserved Protein Domain Family
STKc_MEKK1

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cd06630: STKc_MEKK1 (this model, PSSM-Id:132961 is obsolete and has been replaced by 270800)
Catalytic domain of the Protein Serine/Threonine Kinase, MAP/ERK kinase kinase 1
Serine/threonine kinases (STKs), MAP/ERK kinase kinase 1 (MEKK1) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. MEKK1 is a mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK or MKKK or MAP3K), that phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK1 activates the extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing.
Statistics
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PSSM-Id: 132961
Aligned: 6 rows
Threshold Bit Score: 513.642
Created: 22-Aug-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #####   #            # #                                  #              
Q13233       1242 EWLKGQQIGLGAFSSCYQAQDVgTGTLMAVKQVTYvrntsseqeevvEALREEIRMMSHLNHPNIIRMLGATCeksNYNL 1321 human
XP_001628213  576 HWKKGELLGTGAFSSCYGARDVmTGSLMAVKQVSFcrnskseqdkvcQTIMDEIAILARLKHPHLIKCLGATRhtgHFNI 655  starlet sea a...
XP_002114891    1 QWQKGKLLGTGAYSTCYAARDIkSGTLMAVKQVKQqq--------vyESLIKEISLLNRLNHPNIVRCYGATVqdsHFNI 72   Trichoplax ad...
XP_693316    1073 EWLKGQQIGLGAFSSCYQAQDVgTGTLMAVKQVTYvrntsseqeevvEALREEIRMMGLLNHPHIIRMLGATCeknNYNL 1152 zebrafish
XP_795174     883 NWTKGAILGTGAFSSCYMARDVkTGTLMAVKQISFcrnnagdqedtmEEIKKEIKLMATFDHPHIVRLMGATQhdaHFNV 962  purple urchin
XP_424734    1076 EWLKGQQIGLGAFSSCYQAQDVgTGTLMAVKQVTYvrntsseqeevvEALREEIRMMSHLNHPNIIRMLGATCeksNYNL 1155 chicken
Feature 1          #### ###  #                                   # #### #          ### #          
Q13233       1322 FIEWMaGGSVAHLLSKYGaFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASK-GT 1400 human
XP_001628213  656 FLEWMaGGSISMLLSKYGpFEEAILIRYLRQILQGVSYLHENQVVHRDIKGANILVDSTGQDIRIADFGAAARLATQ-IT 734  starlet sea a...
XP_002114891   73 FAEWLaGGSIASMLHNYGpFQENISNAYCLQILRGLVYLHDRRIVHRDVKGDNILVDATGRIVKLADFGSAIQLTATkLT 152  Trichoplax ad...
XP_693316    1153 FVEWMaGGSVSHLLNKYGaFKEGVIINYTEQLLRGLAYLHENQIIHRDIKGANLLIDSTGQRLRIADFGAAARLASK-GT 1231 zebrafish
XP_795174     963 FVEWMpGGAVSTLLKDFGaFSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRIADLGTAGKMNAD-IT 1041 purple urchin
XP_424734    1156 FIEWMaGGSVAHLLSKYGaFKESVIINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGHRLRIADFGAAARLASK-GT 1234 chicken
Feature 1                 #### #                          #        #                              
Q13233       1401 GAGEFQGQLLGTIAFMAPEVLRGqqYGRSCDVWSVGCAIIEMAcaKPPWNAEKHSNHLALIFKIASAtTAPSIPSHLsPG 1480 human
XP_001628213  735 GAGEFQGQLLGTIAFMAPEVLRGesYGRSCDVWSVGCVLIEMAtgKPPWNAHEHSNHLALIFKIACAiGPPDIPEHLnPG 814  starlet sea a...
XP_002114891  153 GAGLLQGQMVGTVAFMAPEVLRGenYGRSSDVWSLGCVMIQMLtgKLPWGADNISNHFALIYKIATAtETPSVPEHLrQD 232  Trichoplax ad...
XP_693316    1232 GAGEFQGQLLGTIAFMAPEVLRGqqYGRSCDVWSVGCAIIEMScaKPPWNAEKHSNHLALIFKIASAtTAPSIPPHLsPG 1311 zebrafish
XP_795174    1042 RTDEFKGQFLGTISFMAPEVLRGepYGRSCDIWSVGCCIIEMCttKPPWNNTAISNHYQLLFKIASAnGPPPIPESLsPA 1121 purple urchin
XP_424734    1235 GAGEFQGQLLGTIAFMAPEVLRGqqYGRSCDVWSVGCVVIEMAcaKPPWNAEKHSNHLALIFKIASAtTAPSIPSHLsPG 1314 chicken
Feature 1                                      
Q13233       1481 LRDVALRCLELqPQDRPPSRELLKHPVFR 1509 human
XP_001628213  815 VRDVVLRCLESkPEDRPAAVDLLQHPLFT 843  starlet sea anemone
XP_002114891  233 TRDFLLRCLESnREFRPKAKELLIHPLFR 261  Trichoplax adhaerens
XP_693316    1312 LRDVTLRCLELqPTDRPPSRELLKHPVFR 1340 zebrafish
XP_795174    1122 LRDITLRCLEAePSARPGVMELLKHPAFT 1150 purple urchin
XP_424734    1315 LRDVTLRCLELqPQDRPPSRELLKHPVFR 1343 chicken

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