Conserved Protein Domain Family
STKc_MAPKKK_Bck1_like

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cd06629: STKc_MAPKKK_Bck1_like (this model, PSSM-Id:132960 is obsolete and has been replaced by 270799)
Catalytic domain of fungal Bck1-like MAP Kinase Kinase Kinases
Serine/threonine kinases (STKs), mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) subfamily, fungal Bck1-like proteins, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress.
Statistics
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PSSM-Id: 132960
Aligned: 5 rows
Threshold Bit Score: 520.509
Threshold Setting Gi: 57229408
Created: 16-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #####   #            # #                                      #         
417775    1173 FAWMKGEMIGKGSFGAVYLCLNVtTGEMMAVKQVEVPkyssqn--eailstVEALRSEVSTLKDLDHLNIVQYLGFENkn 1250 baker's yeast
1708621    823 FKWMKGELIGNGTYGKVFLAMNInTGELIAVKQVEIPqtingrhdqlrkdiVDSINAEISMIADLDHLNIVQYLGFEKte 902  fission yeast
AAW45841  1462 VNWVKGELIGKGSYGRVYIALNVtTGDMMAVKQVELPateierhdsrqqgmVKALRDEIELLKGLEHKNIVAYLGYETsp 1541 Cryptococcus neo...
EDP45335   843 FKWVKGELIGKGTYGRVYLALNAtTGEMIAVKQVELPrtaadrdssrqrsiVSALKSEIETLKDLDHPNVVTCLGFEEtl 922  Malassezia globo...
BAE57812  1299 FRIIRGQLIGKGTYGRVYLGMNAdNGEVLAVKQVEINpriagqdkdkmkdmVAAMDQEIDTMQHLEHPNIVQYLGCERge 1378 Aspergillus oryzae
1708621    823 FKWMKGELIGNGTYGKVFLAMNInTGELIAVKQVEIPqtingrhdqlrkdiVDSINAEISMIADLDHLNIVQYLGFEKte 902  fission yeast
AAW45841  1462 VNWVKGELIGKGSYGRVYIALNVtTGDMMAVKQVELPateierhdsrqqgmVKALRDEIELLKGLEHKNIVAYLGYETsp 1541 Cryptococcus neo...
EDP45335   843 FKWVKGELIGKGTYGRVYLALNAtTGEMIAVKQVELPrtaadrdssrqrsiVSALKSEIETLKDLDHPNVVTCLGFEEtl 922  Malassezia globo...
BAE57812  1299 FRIIRGQLIGKGTYGRVYLGMNAdNGEVLAVKQVEINpriagqdkdkmkdmVAAMDQEIDTMQHLEHPNIVQYLGCERge 1378 Aspergillus oryzae
Feature 1            #### ###  #                                     # #### #         ### #    
417775    1251 niYSLFLEYVaGGSVGSLIRmy--grFDEPLIKHLTTQVLKGLAYLHsKGILHRDMKADNLLLDqdGICKISDFGISRKS 1328 baker's yeast
1708621    903 tdISIFLEYVsGGSIGRCLRny--gpFEEQLVRFVSRQVLYGLSYLHsKGIIHRDLKADNLLIDfdGVCKISDFGISKHS 980  fission yeast
AAW45841  1542 eyLSIFLEYVpGGTIASIYRtpnqarFEPQLVRFFTEQILEGLAYLHsKNIWHRDLKGDNILVDaqGICKISDFGISKQT 1621 Cryptococcus neo...
EDP45335   923 dtLSIFLEYVpGGSIGSCLRry--gkFEEDMTSSFLNQTLQGLAYLHkQGILHRDLKADNLLVDyqGTCKISDFGTVRRS 1000 Malassezia globo...
BAE57812  1379 lsISIYLEYIsGGSIGSCLRkh--gkFEESVVKSLTQQTLSGLAYLHnQGILHRDLKADNILLDldGTCKISDFGISKKS 1456 Aspergillus oryzae
1708621    903 tdISIFLEYVsGGSIGRCLRny--gpFEEQLVRFVSRQVLYGLSYLHsKGIIHRDLKADNLLIDfdGVCKISDFGISKHS 980  fission yeast
AAW45841  1542 eyLSIFLEYVpGGTIASIYRtpnqarFEPQLVRFFTEQILEGLAYLHsKNIWHRDLKGDNILVDaqGICKISDFGISKQT 1621 Cryptococcus neo...
EDP45335   923 dtLSIFLEYVpGGSIGSCLRry--gkFEEDMTSSFLNQTLQGLAYLHkQGILHRDLKADNLLVDyqGTCKISDFGTVRRS 1000 Malassezia globo...
BAE57812  1379 lsISIYLEYIsGGSIGSCLRkh--gkFEESVVKSLTQQTLSGLAYLHnQGILHRDLKADNILLDldGTCKISDFGISKKS 1456 Aspergillus oryzae
Feature 1                  #### #                             #        #                       
417775    1329 KDIYSNs--DMTMRGTVFWMAPEMVDTkq--gYSAKVDIWSLGCIVLEMFaGKRPWSNlevVAAMFKIGkskSAPPIPED 1404 baker's yeast
1708621    981 DNVYDNd-aNLSMQGSIFWMAPEVIHNdh-qgYSAKVDVWSLGCVVLEMLaGRRPWSTdeaIQAMFKLGtekKAPPIPSE 1058 fission yeast
AAW45841  1622 ADAYDSfgqATNMKGSVFWMAPEVIHSysersYSGKVDIWSLGCVVLEMWsGKRPWGDmeqFAAMFELFnkrSRPPLPPD 1701 Cryptococcus neo...
EDP45335  1001 EDIYANv-eNMSLQGTIFWMAPEVVSLsr-kgYSAKVDIWSLGCVVLEMLaGRRPWSDeeaIQAMFKIGaqrRAPPVPPD 1078 Malassezia globo...
BAE57812  1457 DNIYGNd-sTNSMQGSVFWMAPEVIQSqg-qgYSAKVDIWSLGCVVLEMFaGRRPWSReeaIGAIFKLGslsQAPPIPED 1534 Aspergillus oryzae
1708621    981 DNVYDNd-aNLSMQGSIFWMAPEVIHNdh-qgYSAKVDVWSLGCVVLEMLaGRRPWSTdeaIQAMFKLGtekKAPPIPSE 1058 fission yeast
AAW45841  1622 ADAYDSfgqATNMKGSVFWMAPEVIHSysersYSGKVDIWSLGCVVLEMWsGKRPWGDmeqFAAMFELFnkrSRPPLPPD 1701 Cryptococcus neo...
EDP45335  1001 EDIYANv-eNMSLQGTIFWMAPEVVSLsr-kgYSAKVDIWSLGCVVLEMLaGRRPWSDeeaIQAMFKIGaqrRAPPVPPD 1078 Malassezia globo...
BAE57812  1457 DNIYGNd-sTNSMQGSVFWMAPEVIQSqg-qgYSAKVDIWSLGCVVLEMFaGRRPWSReeaIGAIFKLGslsQAPPIPED 1534 Aspergillus oryzae
Feature 1                                            
417775    1405 tlplISQIGRNFLDACFEIn-PEKRPT-ANELLSHPFS 1440 baker's yeast
1708621   1059 lvsqVSPEAIQFLNACFTVn-ADVRPT-AEELLNHPFM 1094 fission yeast
AAW45841  1702 i--nLSSVALDFLNEKCLAtdPRNRPM-ARDLLQHEFI 1736 Cryptococcus neoformans var. neoformans JEC21
EDP45335  1079 v--kLSKPAAHFLRNCFEId-PDRRPT-AARLLEHVFA 1112 Malassezia globosa CBS 7966
BAE57812  1535 vsmnISPAALAFMYDCFTId-SLDRPTaETLLTRHPFC 1571 Aspergillus oryzae
1708621   1059 lvsqVSPEAIQFLNACFTVn-ADVRPT-AEELLNHPFM 1094 fission yeast
AAW45841  1702 i--nLSSVALDFLNEKCLAtdPRNRPM-ARDLLQHEFI 1736 Cryptococcus neoformans var. neoformans JEC21
EDP45335  1079 v--kLSKPAAHFLRNCFEId-PDRRPT-AARLLEHVFA 1112 Malassezia globosa CBS 7966
BAE57812  1535 vsmnISPAALAFMYDCFTId-SLDRPTaETLLTRHPFC 1571 Aspergillus oryzae

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