Conserved Protein Domain Family
STKc_MEKK3_like

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cd06625: STKc_MEKK3_like (this model, PSSM-Id:132956 is obsolete and has been replaced by 270795)
Catalytic domain of MAP/ERK kinase kinase 3-like Protein Serine/Threonine Kinases
Serine/threonine kinases (STKs), MAP/ERK kinase kinase 3 (MEKK3)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of MEKK3, MEKK2, and related proteins, all containing an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs or MAP3Ks), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates extracellular signal-regulated kinase 5 (ERK5). The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs.
Statistics
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PSSM-Id: 132956
Aligned: 6 rows
Threshold Bit Score: -1
Created: 21-Aug-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #            # #                                 #             
Q99759       359 PINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDspetsKEVSALECEIQLLKNLqHERIVQYYGCLRDraekt 438 human
Q61083       353 PTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPEspetsKEVNALECEIQLLKNLlHERIVQYYGCLRDpqekt 432 house mouse
XP_782621    122 PTNWQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSntdarKEVQSLKQEIELLRNLqHPRIVQYFGCLEEng--t 199 purple urchin
XP_001633473   1 PNNWRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLnsstkNEVKALEGEIEFMKAFrNERIVQYYGIETDdl--h 78  starlet sea ane...
CAG31279     354 PVNWRLGKLLGRGAFGEVYLCYDADTGRELSVKQVPFDPDsqetsKEVNALECEIQLLKTLrHDRIVQYYGCLRDpeerk 433 chicken
XP_001893739 219 PTNWKQGKCIGSGAFGKVYVCVDVDTGKEVALKRFNICRNdkhlkNHINQLENEINLLSTIqHNRIVQYLGAQQIde--s 296 agent of lympha...
Q61083       353 PTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPEspetsKEVNALECEIQLLKNLlHERIVQYYGCLRDpqekt 432 house mouse
XP_782621    122 PTNWQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSntdarKEVQSLKQEIELLRNLqHPRIVQYFGCLEEng--t 199 purple urchin
XP_001633473   1 PNNWRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLnsstkNEVKALEGEIEFMKAFrNERIVQYYGIETDdl--h 78  starlet sea ane...
CAG31279     354 PVNWRLGKLLGRGAFGEVYLCYDADTGRELSVKQVPFDPDsqetsKEVNALECEIQLLKTLrHDRIVQYYGCLRDpeerk 433 chicken
XP_001893739 219 PTNWKQGKCIGSGAFGKVYVCVDVDTGKEVALKRFNICRNdkhlkNHINQLENEINLLSTIqHNRIVQYLGAQQIde--s 296 agent of lympha...
Feature 1            #### ###  #                                   # #### #         ### #        
Q99759       439 LTIFMEYMpGGSVKDQLKAYGaLTESVTRKYTRQILEGMSYLHsNMIVHRDIKGANILRDsaGNVKLGDFGASKRLQTIC 518 human
Q61083       433 LSIFMELSpGGSIKDQLKAYGaLTENVTRKYTRQILEGVHYLHsNMIVHRDIKGANILRDstGNIKLGDFGASKRLQTIC 512 house mouse
XP_782621    200 LSIFMEFMsGGSVKDELRLYGpLTDTVTRKYTRQILEGTAYLHdHHIVHRDIKGANVLRSs-GNVKLADFGASTRLQTIH 278 purple urchin
XP_001633473  79 IYIFMEYLpGGSIHEHIKQHGaLNESLTRKYSRQILEGILYLHtNRIVHRDIKGANILRDlyGNVKLADFGASKRLQTIR 158 starlet sea ane...
CAG31279     434 LSIFVEYMpGGSIKDQLKAYGaLTENVTRKYTRQILQGVFYLHsNMIVHRDIKGANILRDsaGNVKLGDFGASKRIQTIC 513 chicken
XP_001893739 297 ICIFIEYMtGGSVKDYIATYGcLSNTVAGKYTYQILHGLEYLHrNEIIHRDIKPANILRDsnGNVKIGDFGSAKRLQAIC 376 agent of lympha...
Q61083       433 LSIFMELSpGGSIKDQLKAYGaLTENVTRKYTRQILEGVHYLHsNMIVHRDIKGANILRDstGNIKLGDFGASKRLQTIC 512 house mouse
XP_782621    200 LSIFMEFMsGGSVKDELRLYGpLTDTVTRKYTRQILEGTAYLHdHHIVHRDIKGANVLRSs-GNVKLADFGASTRLQTIH 278 purple urchin
XP_001633473  79 IYIFMEYLpGGSIHEHIKQHGaLNESLTRKYSRQILEGILYLHtNRIVHRDIKGANILRDlyGNVKLADFGASKRLQTIR 158 starlet sea ane...
CAG31279     434 LSIFVEYMpGGSIKDQLKAYGaLTENVTRKYTRQILQGVFYLHsNMIVHRDIKGANILRDsaGNVKLGDFGASKRIQTIC 513 chicken
XP_001893739 297 ICIFIEYMtGGSVKDYIATYGcLSNTVAGKYTYQILHGLEYLHrNEIIHRDIKPANILRDsnGNVKIGDFGSAKRLQAIC 376 agent of lympha...
Feature 1                #### #                           #        #                             
Q99759       519 MSGTgmRSVTGTPYWMSPEVISGEg-yGRKADVWSLGCTVVEMLTeKPPWAEYEAMAAIFKIAtqPTNPQLPSHisEHGR 597 human
Q61083       513 LSGTgmKSVTGTPYWMSPEVISGEg-yGRKADIWSVACTVVEMLTeKPPWAEFEAMAAIFKIAtqPTNPKLPPHvsDYTR 591 house mouse
XP_782621    279 SHITgmKTVTGTPYWMSPEIINGEg-yGRRADVWSIGCTVVEMLTtKPPWADYEAMAAIFKIAtkETEPVLPQSvsQDAR 357 purple urchin
XP_001633473 159 SKTGf-RSVHGTPYWMAPEVINGEg-yGRKADVWSVGCTVVEMLTtKPPWADFEPMAALFKIAtqPTEPELPSDlsVDAV 236 starlet sea ane...
CAG31279     514 MSGTgiKSVTGTPYWMSPEVISGEg-yGRKADVWSVACTVVEMLTeKPPWAEFEAMAAIFKIAtqPTNPQLPDGvsSSCR 592 chicken
XP_001893739 377 CQQT--SPFIGTPNYMAPEVVLGHtrhGRKADIWSVGCTLVEMLTaKPPWNNLEPMAIIFNIAkhNPTYQLPIEvdPILS 454 agent of lympha...
Q61083       513 LSGTgmKSVTGTPYWMSPEVISGEg-yGRKADIWSVACTVVEMLTeKPPWAEFEAMAAIFKIAtqPTNPKLPPHvsDYTR 591 house mouse
XP_782621    279 SHITgmKTVTGTPYWMSPEIINGEg-yGRRADVWSIGCTVVEMLTtKPPWADYEAMAAIFKIAtkETEPVLPQSvsQDAR 357 purple urchin
XP_001633473 159 SKTGf-RSVHGTPYWMAPEVINGEg-yGRKADVWSVGCTVVEMLTtKPPWADFEPMAALFKIAtqPTEPELPSDlsVDAV 236 starlet sea ane...
CAG31279     514 MSGTgiKSVTGTPYWMSPEVISGEg-yGRKADVWSVACTVVEMLTeKPPWAEFEAMAAIFKIAtqPTNPQLPDGvsSSCR 592 chicken
XP_001893739 377 CQQT--SPFIGTPNYMAPEVVLGHtrhGRKADIWSVGCTLVEMLTaKPPWNNLEPMAIIFNIAkhNPTYQLPIEvdPILS 454 agent of lympha...
Feature 1                                  
Q99759       598 DFLRRIFVE-ARQRPSAEELLTHHFA 622 human
Q61083       592 DFLKRIFVE-AKLRPSAEELLRHMFV 616 house mouse
XP_782621    358 NFLTLCFKKiLADRPSAAELLRHNFV 383 purple urchin
XP_001633473 237 EFVRSTLRMnSKSRPSADELLRFSFV 262 starlet sea anemone
CAG31279     593 NFLKQIFVE-EKRRPTAEDLLRHPFV 617 chicken
XP_001893739 455 YLISITFERnVDKRPSALQLLNNFDF 480 agent of lymphatic filariasis
Q61083       592 DFLKRIFVE-AKLRPSAEELLRHMFV 616 house mouse
XP_782621    358 NFLTLCFKKiLADRPSAAELLRHNFV 383 purple urchin
XP_001633473 237 EFVRSTLRMnSKSRPSADELLRFSFV 262 starlet sea anemone
CAG31279     593 NFLKQIFVE-EKRRPTAEDLLRHPFV 617 chicken
XP_001893739 455 YLISITFERnVDKRPSALQLLNNFDF 480 agent of lymphatic filariasis

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