3CKX


Conserved Protein Domain Family
STKc_MST3_like

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cd06609: STKc_MST3_like (this model, PSSM-Id:132940 is obsolete and has been replaced by 270786)
Click on image for an interactive view with Cn3D
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Protein Serine/Threonine Kinases
Serine/threonine kinases (STKs), mammalian Ste20-like protein kinase 3 (MST3)-like subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization.
Statistics
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Aligned: 24 rows
Threshold Bit Score: 438.589
Threshold Setting Gi: 68487165
Created: 2-Aug-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The substrate binding site is based on the binding of human PAK4 to a consensus peptide.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #####   #                       # #                #             #      
3CKX_A          7 ELFTKLEKIGKGSFGEVFKGIDnr-----------tqKVVAIKIIDLEeaeDEIEDIQQEITVLSQCd-SPYVTKYYGSY 74   human
1174431        16 KLYSIQSCIGRGNFGDVYKAVDrv-----------tqEIVAIKVVNLEhsdEDIELLAQEIFFLAELk-SPLITNYIATM 83   baker's yeast
729897         21 SLFKRTEVIGRGKFGVVYKGYNvk-----------tgRVYAIKVLNLDsdsDEVEDVQREIQFLASLkqISNITRYYGSY 89   baker's yeast
XP_452238       5 QQFQLLECVGKGNFGDVYLAHYlgsnqeptdpkipknVPLAIKCINLEhsnEPIDLLLKEIYFLSTLh-CPYITHYYGTF 83   Kluyveromyces...
XP_503033      56 DQFELLEELGSGSFGVVYKAIDkv-----------sgQIVAVKKIDLEsseDDIEEIQKEIAILSGCq-DEHITTYYGCF 123  Yarrowia lipo...
O14305          7 NSYTLLRKLGSGSFGVVWKAREnv-----------sgDIIAIKQIDLEtgiDDITDIEQEVFMLSNCn-SSNVIQYYGCF 74   Schizosacchar...
XP_459979       4 DKYKIHQCIGKGNFGDVYKATDis-----------nnTLVAVKVINLDesdEDIAVLIQEIQFLSKLr-SPYITKYFETF 71   Debaryomyces ...
CAB16374        4 HQYRDLQLIGQGSFGSVFRAQDve-----------ssKIVALKVVDLDatkDQIETLTQEINFLIDLn-SVHITKYYASF 71   fission yeast
XP_712526      10 EELEVYEEVGRGGFGVVYRGIIks-----------tnQEVAIKQIDLEkdsTDLIEINKEIQIISECh-CQQITSYMGSF 77   Candida albic...
XP_001484294    3 NKYCLEKCIGRGNFGDVYKAACkr-----------sgKVVAVKVVNLDeslEDMFFMVQEIQFLSLMr-SPYIVQYLESF 70   Pichia guilli...
Feature 1                  ####  ##  #                                     # #### #           #  #
3CKX_A         75 LkdtkLWIIMEYLgGGSALDLLEpg---pLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSe-hGEVKLADFGV 150  human
1174431        84 LedvsMWIVMEYCgGGSCSDLLKrsyvngLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNe-eGMVKLGDFGV 162  baker's yeast
729897         90 LkdtsLWIIMEHCaGGSLRSLLRpg---kIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITn-eGNVKLCDFGV 165  baker's yeast
XP_452238      84 TgdcnLYIVMEYCsNGSLLNLLRyy--srLTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNd-dGEVRLADLGV 160  Kluyveromyces...
XP_503033     124 VrgykLWIIMEYLaGGSGLDLLKpg---iFHEPEIAVMCRELLEGLIYLHDNGKIHRDVKAANVLVSs-eGSVKLADFGV 199  Yarrowia lipo...
O14305         75 VdgytLWILMEHMdGGSVSGLLKmg---rLNEQVISIILREVLYGLNYLHGQNKIHRDIKAANILLSsstGNVKLADFGV 151  Schizosacchar...
XP_459979      72 IndmsMWIVMEYCgGGSCADLLKcy--rkLNEETTAFIIRDVLRGLTYLHEENKVHRDIKLANILLTs-yGEIKLADFGV 148  Debaryomyces ...
CAB16374       72 VdgfrLWITMEYCdGGSCLDLLKls--gtFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMk-dGLVKLADFGV 148  fission yeast
XP_712526      78 VknykLWVIMEFIdGGSIFELLKpg--piDDEKIVSFILYEILLALNYLHNQGKIHRDLKSQNILISk-tGDIKLTDFGV 154  Candida albic...
XP_001484294   71 VensnMWIIMEYCgGGSVADVLRyc--kkFDENIAAYIIKYVLLGLSYLHKQKTVHRDVKLANVLVTt-dGTIKLADFGV 147  Pichia guilli...
Feature 1                           #### #                            #        #                  
3CKX_A        151 AGQLTDTq-----IKRNXFVGTPFWMAPEVIKQSa--YDSKADIWSLGITAIELArGEPPHSELh-PMKVLFLIPKn--- 219  human
1174431       163 SGHIRST------LKRDTFVGTPYWMAPEVVCCEvdgYNEKADIWSLGITTYELLkGLPPLSKYd-PMKVMTNLPKr--- 232  baker's yeast
729897        166 AAQVNQTs-----LRRQTMAGTPYWMAPEVIMEGv-yYDTKVDIWSLGITTYEIAtGNPPYCDVe-ALRAMQLIIKs--- 235  baker's yeast
XP_452238     161 TGQLKFNstrhggKNLNTFVGTPFWMAPEIIKNQs--YDGKCDIWSLGITTLELLnGKPPMSHLd-SMKALMRIPKl--- 234  Kluyveromyces...
XP_503033     200 ATQLSNNm-----SRRNTFVGTPFWMAPEVIRQEd--YDTKADIWSLGITAIEFAkGEPPLSEYh-PMKVLFLIPKa--- 268  Yarrowia lipo...
O14305        152 AAQLSNAa-----SRRHTFVGTPFWMAPEVIQQTs--YGLAADIWSLGITAIEMAnGIPPRATMh-PMRVIFEIPQs--- 220  Schizosacchar...
XP_459979     149 SGEITMTq-----LKRNTFVGTPFWMAPEVITRLktgYNEKADIWSTGITTIELVtGSPPLSQYd-PMKILFEIPKk--- 219  Debaryomyces ...
CAB16374      149 SGQLESLr-----DKNDDFVGTPFWMAPEVVKQTg--YNYKADIWSLGITAYELAtGEPPYSGIh-PMKVLLLIPKh--- 217  fission yeast
XP_712526     155 STQLSSNf-----SKRNTTVGTPYWMAPEVIVNNnggHSYKADIWSLGCCCYEMFtGKPPLQSKypPMRALRLISKcqkn 229  Candida albic...
XP_001484294  148 SGEMSFTt-----NKRSTFVGTPYWMAPEVIVHSklgYNEKADIWSTGITTIELIkGDPPLADYd-PMKILFKIPKq--- 218  Pichia guilli...
Feature 1                                                                           
3CKX_A        220 --NPPTLEGN---YSKPLKEFVEACLNKePSFRPTAKELLKHKFILRnakktsyltELIDRYKRWK 280  human
1174431       233 --KPPKLQGP---FSDAAKDFVAGCLVKtPADRPSAYNLLSFEFVKNitit--nlkSDVDLIKQKK 291  baker's yeast
729897        236 --KPPRLEDRs--YSTSLKEFIALCLDEdPKERLSADDLLKSKFIRAhkat--ptsILKELISRYL 295  baker's yeast
XP_452238     235 --NADSILRNm-dISPLGKDFIRSCLQQdPNQRPTCKQLLQHKWLKKcs-----itNIMEEITVMK 292  Kluyveromyces lactis NRRL Y...
XP_503033     269 --EPPTVPAGg-nWSADFRDFVACCLRKnPAERPSGRQLLKHRFIRKagkt-sqlkLLVDRRERWM 330  Yarrowia lipolytica CLIB122
O14305        221 --EPPKLDDH---FSPTFRDFVSCCLDLnPNMRWSAKELLQHPFIKSagtvkdiipLLVQKENKLF 281  Schizosaccharomyces pombe
XP_459979     220 --RPPLLTGVd--FSENIKDFVRYCLIKdPKKRPSSSTLLHHKFLKNikrn-vnlfKLLEEKNKWS 280  Debaryomyces hansenii CBS767
CAB16374      218 --SPPSLERSk--FSRAFCDFVSNCLKKnPKDRATAEYLSKHKFIKKycpn-tsvkEVVASYAKWK 278  fission yeast
XP_712526     230 qdFIKLIELNeldISWEFKDFLHQCFIEdPKLRASASKLLKHKFITKhihdkdkikLLKKLITKKQ 295  Candida albicans SC5314
XP_001484294  219 --EPPLLTGDk--YSDELKGFLEKCLVKnPRKRSSSTELLDHPFIGIaaeqqdfckLLRRRRTSFL 280  Pichia guilliermondii ATCC ...

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