1XP9,1XB7,2PJL,1KV6,2PJL,1YY4


Conserved Protein Domain Family
NR_LBD_ER_like

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cd07068: NR_LBD_ER_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of estrogen receptor and estrogen receptor-related receptors
The ligand binding domain of estrogen receptor (ER) and estrogen receptor-related receptors (ERRs): Estrogen receptors are a group of receptors which are activated by the hormone estrogen. Estrogen regulates many physiological processes including reproduction, bone integrity, cardiovascular health, and behavior. The main mechanism of action of the estrogen receptor is as a transcription factor by binding to the estrogen response element of target genes upon activation by estrogen and then recruiting coactivator proteins which are responsible for the transcription of target genes. Additionally some ERs may associate with other membrane proteins and can be rapidly activated by exposure of cells to estrogen. ERRs are closely related to the estrogen receptor (ER) family. But, it lacks the ability to bind estrogen. ERRs can interfere with the classic ER-mediated estrogen signaling pathway, positively or negatively. ERRs share target genes, co-regulators and promoters with the estrogen receptor (ER) family. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ER and ERRs have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132753
View PSSM: cd07068
Aligned: 21 rows
Threshold Bit Score: 262.158
Threshold Setting Gi: 74935853
Created: 30-Jan-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1XP9_a; human estrogen receptor alpha binds to a Dihydrobenzoxathiin, molecule 18, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ## ### ##  
1XP9_A         9 MVSALLDAE-PPILYSEYdptrp-------------------------------------fseaSMMGLLTNLADRELVH 50
gi 74935853  237 ILEVLNSYE-PDALSVQTpppqvhttsitndeassssgsiklessvvtpngtcifqnnnnndpnEILSVLSDIYDKELVS 315
gi 110756963 223 MLEALAACE-PDMLQVSNishtl-------------------------------------dtdqRVLGQLSDLYDRELVG 264
gi 212516486 226 ILEALSLNE-PDISVMAQdisna-------------------------------------dpavRTLNILSDLYDQELVK 267
gi 75008484  202 ILEALQKADlPVMDSYHNhnlp--------------------------------------atrvHLLNTLIKLADRELVY 243
1YY4_A         6 LVLTLLEAE-PPHVLISRpsap--------------------------------------fteaSMMMSLTKLADKELVH 46
gi 170178459 308 LISHLVNIE-PNPILTGYnpqct-------------------------------------ptegYLMALVTDLANREIEG 349
gi 82209527  285 LISRIMEAE-PPEIYLMKdmkkp-------------------------------------fteaNVMMSLTNLADKELVH 326
gi 119597    309 MVSALLEAE-PPIVYSEYdpnrp-------------------------------------fneaSMMTLLTNLADRELVH 350
gi 6015120   307 LISALMEAE-APIVYSEHdstkp-------------------------------------lseaSMMTLLTNLADRELVH 348
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #   ##     #          #                   #           
1XP9_A        51 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG-KLLFAPNLLLDrnqgkcvegmvEIFDMLLATSSRF 129
gi 74935853  316 VIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNG-KLCFATDVWMDehlak-ecgytEFYYHCVQIAQRM 393
gi 110756963 265 IIGWAKQIPGFSSLALNDQMRLLQSTWAEILTFSLAWRSMPNNG-RLRFAQDFTLDerlar-echctELYTHCIQIVERL 342
gi 212516486 268 IITWAKHIPGFLDLTLNDQMRLLQSTWAEILTLTVTYRSLPGTG-ELKFAADFSFDekmar-ecgamDIYQHCMHIVERQ 345
gi 75008484  244 LINWAKHVPGYTCLTLGDQVHLIECCWMELLLLNCAFRSMEHEGrTLVFAPDFHLErqqwa-ltgmgDVLEQVSAVSEQM 322
1YY4_A        47 MISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPG-KLIFAPDLVLDrdegkcvegilEIFDMLLATTSRF 125
gi 170178459 350 LVDWAARLPGYGMLPMDDQVNLIRTVWLDLLMLGLVWRSMEHRGeWLVFAPDLLMDrslcr-lsgmeYICTPMLEFARQF 428
gi 82209527  327 MISWAKKIPGFVELSLFDQVHLLECCWLEVLMLGLMWRSVNHPG-KLIFSPDLCLSrdesscvqglvEIFDMLLAATSRF 405
gi 119597    351 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG-KLLFAPNLLLDrnqgkcvegmvEIFDMLLATAARF 429
gi 6015120   349 MINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSVEHPG-KLSFAPNLLLDrnqgrcveglvEIFDMLVTTATRF 427
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1XP9_A       130 RmMNLQGEEFVCLKSIILLNSGVYtflsstlksleEKDHIHRVLDKITDTLIHLMAkagltlqqqhqRLAQLLLILSHIR 209
gi 74935853  394 ErISPRREEYYLLKALLLANCDILl---------dDQSSLRAFRDTILNSLNDVVYllrhs--savsHQQQLLLLLPSLR 462
gi 110756963 343 QrLGLTREEYYVLKALILANSDARs---------dEPQALYRFRDSILNSLSDCMAavrpg--qalrATQNMFLVLPSLR 411
gi 212516486 346 EkLNITKEEYYIIKALVLANSDVRi---------dDLPPLKKLRDNILSALADCVAvlrpn--ttslHMNHLLLCLPALR 414
gi 75008484  323 LlHGLNKEELLLLQATVLVNAEVRpl--------dSFLKIQEMRQLILDVFMEVAGrhqgf--gnwrHAPSILLLLTHIR 392
1YY4_A       126 ReLKLQHKEYLCVKAMILLNSSMYplvta-tqdadSSRKLAHLLNAVTDALVWVIAksgissqqqsmRLANLLMLLSHVR 204
gi 170178459 429 AdLQVPQEVYVCLKALTLYTTAVSrl--------qDYRQVQRLQHEINEALAEACSstfg---fspgNIARLMMIVSQVR 497
gi 82209527  406 ReLKLQREEYVCLKAMILLNSNMClgsseggedlqSRSKLLCLLDSVTDALVWAISktglsfqqrstRLAHLLMLLSHIR 485
gi 119597    430 RmMNLQGEEFVCLKSIILLNSGVYtflsstlksleERDYIHRVLDKITDTLIHLMAksglslqqqhrRLAQLLLILSHIR 509
gi 6015120   428 RmMRLRGEEFICLKSIILLNSGVYtflsstlesleDTDLIHIILDKIIDTLVHFMAksglslqqqqrRLAQLLLILSHIR 507
                        250       260       270
                 ....*....|....*....|....*....|.
Feature 1             #  ##     #    #          
1XP9_A       210 HMSNKGMEHLysMKCKNVVPLYDLLLEMLDA 240
gi 74935853  463 QADDILRRFWrgIARDEVITMKKLFLEMLEP 493
gi 110756963 412 QVDGIVRRFWssVYRTGKVPMNKLFVEMLEA 442
gi 212516486 415 QADYINRRFWtaVHREGKVYMNKLFIEMLES 445
gi 75008484  393 QAGERGITYFqkLKMEGCVTFCDLLTEMLDA 423
1YY4_A       205 HASNKGMEHLlnMKCKNVVPVYDLLLEMLNA 235
gi 170178459 498 QLSSLGVDHLnrLRGAETVSVEGLLREIVDE 528
gi 82209527  486 HVSNKGMDHLhcMKMKKMVPLYDLLLEMLDA 516
gi 119597    510 HMSNKGMEHLynMKCKNVVPLYDLLLEMLDA 540
gi 6015120   508 HMSNKGMEHLysMKCKNVVPLYDLLLEMLDA 538

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