1WPA


Conserved Protein Domain Family
Occludin_ELL
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pfam07303: Occludin_ELL (this model, PSSM-Id:115928 is obsolete and has been replaced by 429396)
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Occludin homology domain
This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.
Links
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Statistics
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PSSM-Id: 115928
Aligned: 18 rows
Threshold Bit Score: 114.694
Threshold Setting Gi: 75765366
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WPA_A  12 YPPITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYRE---ESEEYMAAA----DEYNR-LkqvKGSA 83  human
Q95RS9 204 YVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRcdnGYGDYDHIKrqivCEYER-I---NNDR 279 fruit fly
Q8VCR9 106 YPPVTNRRDRSRYAAVFQDQYGEFSELQREVGATQAKLQQLEALLLSLPPp--RSQKEARMAahvrREFEK-K---RVDP 179 house mouse
Q9H607 153 YPPVSSERERSRYVAVFQDQYGEFLELQHEVGCAQAKLRQLEALLSSLPPp--QSQKEAQVAarvwREFEM-K---RMDP 226 human
Q8N4S9 446 YPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHhseSRQEHERISri-hEEFKK-Kk--N-DP 520 human
Q5XFX8 281 YSTIHSAEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIKRLQR---GTPEHKVLEdkivQEYKK-Fr--KRYP 354 Norway rat
O00472 532 YIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSP---GSKEYQNVHeevlQEYQK-Ik--QSSP 605 human
O08856 494 YPAISSSEQRQSYKNDFNAEYSEYRSLHARIEQITRRFTQLDAQLRQLSQ---GSDEYETTRgqilQEYRK-Ik--KTNT 567 house mouse
Q6PEG4 525 YTVISSPEQRQTYKNDFNSEYSEYRGLHARIESITRQFTILDSELKQLQQ---GTDKYKTIHnqilEEYRK-Ik--KTNP 598 zebrafish
Q7PMS0 183 FTRITSVEQRRRYKTEFDNEYKEYRRLHEVLENASRKFAQYEDDLSHEPK---DTQRYKEIQlkilKEYERsFknvK--- 256 Anopheles gambiae str...
Q95RS9 204 YVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRcdnGYGDYDHIKrqivCEYER-I---NNDR 279 fruit fly
Q8VCR9 106 YPPVTNRRDRSRYAAVFQDQYGEFSELQREVGATQAKLQQLEALLLSLPPp--RSQKEARMAahvrREFEK-K---RVDP 179 house mouse
Q9H607 153 YPPVSSERERSRYVAVFQDQYGEFLELQHEVGCAQAKLRQLEALLSSLPPp--QSQKEAQVAarvwREFEM-K---RMDP 226 human
Q8N4S9 446 YPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHhseSRQEHERISri-hEEFKK-Kk--N-DP 520 human
Q5XFX8 281 YSTIHSAEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIKRLQR---GTPEHKVLEdkivQEYKK-Fr--KRYP 354 Norway rat
O00472 532 YIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSP---GSKEYQNVHeevlQEYQK-Ik--QSSP 605 human
O08856 494 YPAISSSEQRQSYKNDFNAEYSEYRSLHARIEQITRRFTQLDAQLRQLSQ---GSDEYETTRgqilQEYRK-Ik--KTNT 567 house mouse
Q6PEG4 525 YTVISSPEQRQTYKNDFNSEYSEYRGLHARIESITRQFTILDSELKQLQQ---GTDKYKTIHnqilEEYRK-Ik--KTNP 598 zebrafish
Q7PMS0 183 FTRITSVEQRRRYKTEFDNEYKEYRRLHEVLENASRKFAQYEDDLSHEPK---DTQRYKEIQlkilKEYERsFknvK--- 256 Anopheles gambiae str...

1WPA_A  84 DYKSKKNHCKQLKSKLSHIKKMVGDYDR 111 human
Q95RS9 280 TIGEDKERFDYLHAKLAHIKQLVMDYDK 307 fruit fly
Q8VCR9 180 GFLDKQARCNYLKGKLRHLKAQIRKFDD 207 house mouse
Q9H607 227 GFLDKQARCHYLKGKLRHLKTQIQKFDD 254 human
Q8N4S9 521 TFLEKKERCDYLKNKLSHIKQRIQEYDK 548 human
Q5XFX8 355 SYSEEKRRCEYLHEKLSHIKGLILEFEE 382 Norway rat
O00472 606 NYHEEKYRCEYLHNKLAHIKRLIGEFDQ 633 human
O08856 568 NYSCEKRRCEYLHRKLAHIKRLIAEYDQ 595 house mouse
Q6PEG4 599 NYSQEKNRCEYLHNKLAHIKKLIAEYDQ 626 zebrafish
Q7PMS0 257 -FQQDKERFNYLHKKLSHIKLLVRDYDT 283 Anopheles gambiae str. PEST
Q95RS9 280 TIGEDKERFDYLHAKLAHIKQLVMDYDK 307 fruit fly
Q8VCR9 180 GFLDKQARCNYLKGKLRHLKAQIRKFDD 207 house mouse
Q9H607 227 GFLDKQARCHYLKGKLRHLKTQIQKFDD 254 human
Q8N4S9 521 TFLEKKERCDYLKNKLSHIKQRIQEYDK 548 human
Q5XFX8 355 SYSEEKRRCEYLHEKLSHIKGLILEFEE 382 Norway rat
O00472 606 NYHEEKYRCEYLHNKLAHIKRLIGEFDQ 633 human
O08856 568 NYSCEKRRCEYLHRKLAHIKRLIAEYDQ 595 house mouse
Q6PEG4 599 NYSQEKNRCEYLHNKLAHIKKLIAEYDQ 626 zebrafish
Q7PMS0 257 -FQQDKERFNYLHKKLSHIKLLVRDYDT 283 Anopheles gambiae str. PEST
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