1GSO


Conserved Protein Domain Family
GARS_A

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pfam01071: GARS_A (this model, PSSM-Id:110097 is obsolete and has been replaced by 307287)
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Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase (see pfam02786).
Statistics
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PSSM-Id: 110097
View PSSM: pfam01071
Aligned: 19 rows
Threshold Bit Score: -1
Threshold Setting Gi: 0
Created: 5-Apr-2011
Updated: 12-Apr-2011
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GSO_A      105 GSKAFTKDFLARHKIPTA-EYQNFT--E-VEPALAYLREKGAPI-----VIKADGLAAGKGVIVA----MTLEEAEAAVH 171
gi 3024481  103 ASKSWTKQLLIEAGVPTA-FGETFT--E-PAPAQAYATKMGAPI-----VVKADGLAAGKGVIVA----QTSAEATTAIA 169
gi 3024486  101 GSKAFAKEVMAAAGVRTS-RSEIVN--S-PARLDAALDRFGPPVgdlswVVKDDRLAAGKGVVVT----SDRDVARTHAA 172
gi 54041753 101 GSKAFAKDVMAAAGVRTA-NSEIVD--S-PAHLDAALDRFGPPAgdpawVVKDDRLAAGKGVVVT----ADRDVARAHGA 172
gi 131611   101 GSKQFAKDLMKKYDIPTA-EYETFT--S-FDEAKAYVQEKGAPI-----VIKADGLAAGKGVTVA----MTEEEAIACLH 167
gi 12644306 198 GSKNFMKNLCHKYNIPTA-KYKTFS--D-ASAAKEYIQEQGAPI-----VIKADGLAAGKGVTVA----MELEEAFEAVD 264
gi 1172752  103 GSKAFTKDFLARHKIPTA-EYQNFT--E-VEPALTYLREKGTPI-----VVKADGLAAGKGVIVA----MTLQEAEDAVR 169
gi 3024488  103 TNKEFMRNLFKKYNIKGSlMYKAFE--EyGEELESFIDELTEKGik--aVVKPVGLTGGKGVKVVgeqlKDNEEAKKYAK 178
gi 7994661  109 ASKCWAKDFLKRIGVPIP-EYANFD--N-PEEAKEYIREKFNNGi----VVKADGLAAGKGVYVC----DSVEEALRAVD 176
gi 74964353 100 TSKSFSKHFMKEYGLPTA-DFVTVSieN-VKSLDCVFERLPWKNs----VVKADGLAAGKGVIIP----RNNAEAVEAAR 169
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GSO_A      172 DMLAgnafgdagHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDKDT-------------------------- 225
gi 3024481  170 ELFDqg-----fEKIVVEEFLPGEEVSVLALCDGKTVIPLLPAQDHKRIGEGDQ-------------------------- 218
gi 3024486  173 GLLea------gHPVLLESYLDGPEVSLFCVVDGRTVLPLLPAQDFKRVGEGDT-------------------------- 220
gi 54041753 173 ALLea------gHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDT-------------------------- 220
gi 131611   168 DFLEdekfgdasASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFDGDK-------------------------- 221
gi 12644306 265 SMLVkgvfgsagCQVVVEEFLEGEEASFFALVDGENAIPLESAQDHKRVGDGDT-------------------------- 318
gi 1172752  170 DMLSgnafgeagSRVVIEEFLDGEEASFIVMVDGKNVEPMASSQDHKRVGENDT-------------------------- 223
gi 3024488  179 EIFEtgl---ggGKVLIEEKLEGVEFTLHGFVDGDTIKFTPFVQDHPHALEGDE-------------------------- 229
gi 7994661  177 EIMVqkkfgeagNRIVVEERLRGIEVAFTAMTDGKTVKPFGHARDYKRAFDSDDieglrdfyigltkkfytkaqieqlyr 256
gi 74964353 170 SILHgqfg-nagRTVIIEERLEGYEVSALAFTDGISFKRMPLGKDHKRLLESDL-------------------------- 222
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GSO_A      226 -----GPNTGGMGAYS----PAPVVTDDVHQRTMErIIWPTVKGMAAEGNTYTGFLYAGLMID-KQGn--PKVIEFNCRF 293
gi 3024481  219 -----GLNTGGMGAYC----PAPIAPPAVIDQVQKqILQPTANALAKRGIDYRGVLYAGLMVS-PTGe--IKVLEYNCRF 286
gi 3024486  221 -----GPNTGGMGAYA----PLPWLPDEVCQQALTsIVEPVAAELVQRGSPFRGLLYVGLAVT-ASG---PAVVEFNCRF 287
gi 54041753 221 -----GLNTGGMGAYA----PLPWLPDNIYREVVSrIVEPVAAELVRRGSSFCGLLYVGLAIT-ARG---PAVVEFNCRF 287
gi 131611   222 -----GPNTGGMGAYS----PVPQISEETVRHAVEtIVKPAAKAMVQEGRSFTGVLYAGLMLT-ENG---SKVIEFNARF 288
gi 12644306 319 -----GPNTGGMGAYS----PAPVLTKELQDFVMEsIIHPTVKGMAEEGCKFVGVLFAGLMIEkKSGl--PKLIEFNVRF 387
gi 1172752  224 -----GLNTGGMGAYS----PAPVITPEIHSRIMKeVIYPTVNGMAAEGNVYTGFLYAGLMIM-PNGq--PKVIEFNCRF 291
gi 3024488  230 -----GSITGGMGSYScpdhKLPFMTEEDVKLAKE-IMEETVKALKEEVGGYKGILYGQFMLT-KEG---PKIIEYNARF 299
gi 7994661  257 egkliNPNTGGMGAVS----PHPAVTEEVEQRIMEmVVEPIIENFDKE---FKGVLYPVIMLVeENGeliPKVLEINVRD 329
gi 74964353 223 -----GPNT-GMGVVA----PVSV--PKEVDRQIDeIFEKTLKGLADRKIKYCGVLYAGFMIV-DQK---PLLLEFNCRF 286

                ....*
1GSO_A      294 GDLET 298
gi 3024481  287 GDPET 291
gi 3024486  288 GDPET 292
gi 54041753 288 GDPET 292
gi 131611   289 GDPET 293
gi 12644306 388 GDPEC 392
gi 1172752  292 GDPET 296
gi 3024488  300 GDPEA 304
gi 7994661  330 CDPGA 334
gi 74964353 287 GDPET 291
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