2E4U


Conserved Protein Domain Family
PBP1_mGluR_groupII
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cd06375: PBP1_mGluR_groupII (this model, PSSM-Id:107370 is obsolete and has been replaced by 380598)
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Ligand binding domain of the group II metabotropic glutamate receptor
Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes
Links
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Statistics
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PSSM-Id: 107370
Aligned: 8 rows
Threshold Bit Score: 855.22
Created: 6-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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ligand-bindingdimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand-binding site [chemical binding site]
Evidence:
  • Structure:2E4U; Rattus norvegicus mGuR subtype II complexed with glutamate, contacts calculated at 3.5 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #                                              
2E4U_A      13 GDLVLGGLFPINEKGtgt------eeCGRINEDRGIQRLEAMLFAIDEINkdnyLLPGVKLGVHILDTCSRDTYALEQSL 86   Norway rat
XP_692887   37 GDLVIGGLFPVHEKGkgt------edCGKINEERGIQRLEAMLLALDEINqdnrILPGLKLGAHILDTCSKDTYALEQSL 110  zebrafish
CAA67993    43 GDIILGGLFPVHEKGeg-------apCGPKVYNRGVQRLEAMLYAIDRVNndpnILPGITIGVHILDTCSRDTYALNQSL 115  fruit fly
XP_784936  601 GDLMIGGLFPIHEKGsqnvgsldderCGLINEDRGIQRVEAMLFAIDKINndstILPGIRLGASLRDTCSIDTFALEQSL 680  purple urchin
Q14416      30 GDLVLGGLFPVHQKGgpa------edCGPVNEHRGIQRLEAMLFALDRINrdphLLPGVRLGAHILDSCSKDTHALEQAL 103  human
XP_416842   37 GDLVLGGLFPINEKGtgi------eeCGRINEDRGIQRLEAMLFAIDEINrdnyLLPGIKLGVHILDTCSRDTYALEQSL 110  chicken
XP_972407   39 GDIILGGLFPVHKKGer-------taCSQQIYHRGVQRLEAMMFAIDRINsnprILPNITLGVHILDTCSRDTYALNQSL 111  red flour beetle
CAM56446    31 GDLVLGGLFPIHEKGmgm------deCGRINEDRGIQRLEAMLFAIDQINqdvaLLPGVVLGVHILDTCSRDTYALEQAL 104  zebrafish

Feature 1                                                #                    ###              
2E4U_A      87 EFVRASLtkvdeaeymcpd--gsyaiqeniplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 164  Norway rat
XP_692887  111 AFVRASLtkvhqpgficpd--gsnpvpdelplAISGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 188  zebrafish
CAA67993   116 QFVRASLnnldtsgyecadgsspqlrknassgPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFA 195  fruit fly
XP_784936  681 EFVRVSLttsnpadclnk----stivastsagSVAGVIGGSYSTVSMQVANLLRLFEIPQISYASTSARLSDKSRFEFFA 756  purple urchin
Q14416     104 DFVRASLsrgadgsrhicp-dgsyathgdaptAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182  human
XP_416842  111 EFVRASLtkvdeteymcpd--gsyaiqenlplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 188  chicken
XP_972407  112 QFVRASVnnidtsalecvd-hsiprprnnytgPVFGVVGGSYSSVSLQVANLLGLFHIPQISPASTAKALSDKTRFEYFA 190  red flour beetle
CAM56446   105 EFVRASLtkvddteficpd--gsyalqedsplAIAGVIGGSFSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182  zebrafish

Feature 1                                       #                                              
2E4U_A     165 RTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVgrsn-irksYDSVIRELLQKP 243  Norway rat
XP_692887  189 RTVPPDFYQAKAIAEILRyFNWTYVSTVASEGDYGETGIDAFQQEARVRQICIATSVKVsrsv-nqgnYETVIRSLQQKA 267  zebrafish
CAA67993   196 RTVPPDTFQSVALVDILKnFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVpsaa-ddkvFDSIISKLQKKP 274  fruit fly
XP_784936  757 RTVPPDTLQAKAIADILShFNWTYVSTVWSSGEYGESGMDQFEKERLHRNICIAASEKIpysp-damtYDIIISRLIKKK 835  purple urchin
Q14416     183 RTVPPDFFQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVgram-sraaFEGVVRALLQKP 261  human
XP_416842  189 RTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATSEKVgrsn-irksYDGVIRELLQKP 267  chicken
XP_972407  191 RTVPPDTFQSSALVDIVKsVNWSYVSTIYSEGSYGEYGIEVFHREAQERNVCIATAEKVpsta-ddhaFDNIIMKLKKKV 269  red flour beetle
CAM56446   183 RTVPPDFYQAKAMAEILRaFNWTYVSTVASEGDYGETGIEAFEQQARLRNICIATSEKVgrssakrssYEAVVRQLLQKP 262  zebrafish

Feature 1                                         #                                            
2E4U_A     244 NARVVVLFmRSDDSRELIAAANRVNAS--FTWVASDGWGAQESIVkgsEHVAYGAITLELashpVRQFDRYFQSLNPYNN 321  Norway rat
XP_692887  268 NAKVVILFtRSEDARELLAAAARMNVT--FIWVASDGWGAQESVVhdsEKAANGAFTIELasysIREFEDYFTKLTPELN 345  zebrafish
CAA67993   275 NARGVVLFtRAEDARRILQAAKRANLSqpFHWIASDGWGKQQKLLeglEDIAEGAITVELqseiIADFDRYMMQLTPETN 354  fruit fly
XP_784936  836 AAKVVVLFtRDVDARDLLEAALRVNASkkFIWVASDGWGVQDTPVngrETVAEGAITIELqtkkIKGFDQYFRGINPRTN 915  purple urchin
Q14416     262 SARVAVLFtRSEDARELLAASQRLNAS--FTWVASDGWGALESVVagsEGAAEGAITIELasypISDFASYFQSLDPWNN 339  human
XP_416842  268 NARVVVLFmRGDDSRELIAAANRFNVS--FTWIASDGWGAQESIVkgnEHIASGAITLELashpVKEFDRYFQSLSPYNN 345  chicken
XP_972407  270 NARGVVLFtRAEDARRILQAAKRLNAShtFYWVASDGWGKQQKLVeglEDVAEGAITVELqsdnIPGFDEYMMSLTPETN 349  red flour beetle
CAM56446   263 TARVAVLFlRSDDARELIAAAARLNAS--FLWVASDGWGAQESIVkgnEFTADGAITLELaahpIPDFNRYFQTLTPQIN 340  zebrafish

Feature 1                                                                    #                 
2E4U_A     322 HRNPWFRDFWEQKFQCSLqnkrnhrqvc-------------------dkhlaidssnYEQESKIMFVVNAVYAMAHALHK 382  Norway rat
XP_692887  346 TRNPWFREYWEHNFGCNLqdhgcas-------------------------kslrndlFKPESKIMFVVNAVYAMAYALHN 400  zebrafish
CAA67993   355 QRNPWFAEYWEDTFNCVLtslsvkpdtsnsanstdnkigvkaktecddsyrlsekvgYEQESKTQFVVDAVYAFAYALHN 434  fruit fly
XP_784936  916 TRNPWFKDFWEQKFQCLLepgdsvntstp------------------caenvldeanHAQEKKTQFVVDAVFAMAHALHT 977  purple urchin
Q14416     340 SRNPWFREFWEQRFRCSFrqrdcaa-------------------------hslravpFEQESKIMFVVNAVYAMAHALHN 394  human
XP_416842  346 RRNPWFKDFWEQKFQCNLqnrkphkktc-------------------dkhftinssnYEQESKIMFVVNAVYAMAHALHK 406  chicken
XP_972407  350 LRNPWFEQYWEDTFDCILeknvplithtnfn-------------vckpelrlsqkvgYEQESKVQFVVDAVYAFALALHN 416  red flour beetle
CAM56446   341 HRNPWFKDFWEQKFQCSLggtsatgagtpkp--------------pcdqelvidksnFEPESKIMFVVNAVYAMAHALHR 406  zebrafish

Feature 1                                                                                      
2E4U_A     383 MQRTLCPqtt--------------------------klCDAMKILDGKKLYKEYLLKiqftapfnpnkgaDSIVKFDTFG 436  Norway rat
XP_692887  401 MRQAVCPntt--------------------------kvCDAMKPGNGKRFYREFILKtkfdap-frpadtENVVRFTSLG 453  zebrafish
CAA67993   435 LHNDRCNtqsdqttetrkhlqsesvwyrkistdtksqaCPDMANYDGKEFYNNYLLNvsfi------dlaGSEVKFDRQG 508  fruit fly
XP_784936  978 MQTDMCPhte--------------------------elCDNMLPIDGRKLFKEYILNttfv------dlaDTEVSFDSQG 1025 purple urchin
Q14416     395 MHRALCPntt--------------------------rlCDAMRPVNGRRLYKDFVLNvkfdap-frpadtHNEVRFDRFG 447  human
XP_416842  407 MQRTLCPntt--------------------------klCDAMKHLDGKKLYKDYLLKvnftapfnppnaaDSTVKFDAYG 460  chicken
XP_972407  417 LYRDLCKdyrk------------------------sgvCPAMTQYDGGDFYKKYLLNvsft------dlaGSPVKFDHRG 466  red flour beetle
CAM56446   407 MQRTLCAntt--------------------------rlCDAMRSLDGRKLYRDFLLHvnfrap-fspaglESQVKFDAYG 459  zebrafish

Feature 1                                        
2E4U_A     437 DGMGRYNVFNLqqtggkysYLKVGHWaETLSLDV 470  Norway rat
XP_692887  454 DSLGRYNIFHYrkednkyvYRKVGYWaQGLVLNT 487  zebrafish
CAA67993   509 DGLARYDILNYqrqenssgYQYKVIGkWFNGLQL 542  fruit fly
XP_784936 1026 DGLGRYDVMNYrpiegtddYRYVKVGeWANILSM 1059 purple urchin
Q14416     448 DGIGRYNIFTYlrag-sgrYRYQKVGyWAEGLTL 480  human
XP_416842  461 DGIGRYNVFNFqytgdrysYVKVGHWaETLSLEV 494  chicken
XP_972407  467 DGLARYDILNYqrlinasgYHYRVVGkWFNSLEL 500  red flour beetle
CAM56446   460 DGVGRYNIFNYqsvpgsdkFAYVQVGeWAESLSL 493  zebrafish

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