Conserved Protein Domain Family
Spg1

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cd04128: Spg1 
Septum-promoting GTPase (Spg1)
Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization.
Statistics
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PSSM-Id: 206701
View PSSM: cd04128
Aligned: 11 rows
Threshold Bit Score: 315.873
Threshold Setting Gi: 28396142
Created: 30-Aug-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Based on sequence similarity with other Rab isoforms.
  • Comment:The active conformation of Rab is stabilized by interations between the gamma phosphate of GTP and two critically conserved residues, Thr in switch I and Gly in switch II

cd04128 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd04128 is a member of the superfamily cl21455.
cd00066:G-alphacd00154:Rabcd00157:Rhocd00876:Rascd00877:Rancd00878:Arf_Arlcd00879:Sar1cd00880:Era_likecd00881:GTP_translation_factorcd00882:Ras_like_GTPasecd01850:CDC_Septincd01851:GBPcd01852:AIG1cd01853:Toc34_likecd01860:Rab5_relatedcd01861:Rab6cd01862:Rab7cd01863:Rab18cd01864:Rab19cd01865:Rab3cd01866:Rab2cd01867:Rab8_Rab10_Rab13_likecd01868:Rab11_likecd01869:Rab1_Ypt1cd01870:RhoA_likecd01871:Rac1_likecd01873:RhoBTBcd01874:Cdc42cd01875:RhoGcd01876:YihA_EngBcd01878:HflXcd01879:FeoBcd01881:Obg_likecd01882:BMS1cd01883:EF1_alphacd01884:EF_Tucd01885:EF2cd01886:EF-Gcd01887:IF2_eIF5Bcd01888:eIF2_gammacd01889:SelB_eukcd01890:LepAcd01891:TypA_BipAcd01892:Miro2cd01893:Miro1cd01894:EngA1cd01895:EngA2cd01896:DRGcd01897:NOGcd01898:Obgcd01899:Ygr210cd01900:YchFcd04101:RabL4cd04102:RabL3cd04103:Centaurin_gammacd04104:p47_IIGP_likecd04105:SR_betacd04106:Rab23_likecd04107:Rab32_Rab38cd04108:Rab36_Rab34cd04109:Rab28cd04110:Rab35cd04111:Rab39cd04112:Rab26cd04113:Rab4cd04114:Rab30cd04115:Rab33B_Rab33Acd04116:Rab9cd04117:Rab15cd04118:Rab24cd04119:RJLcd04120:Rab12cd04121:Rab40cd04122:Rab14cd04123:Rab21cd04124:RabL2cd04126:Rab20cd04127:Rab27Acd04128:Spg1cd04129:Rho2cd04130:Wrch_1cd04131:Rndcd04132:Rho4_likecd04133:Rop_likecd04134:Rho3cd04135:Tc10cd04136:Rap_likecd04137:RheBcd04138:H_N_K_Ras_likecd04139:RalA_RalBcd04140:ARHI_likecd04141:Rit_Rin_Riccd04142:RRP22cd04143:Rhes_likecd04144:Ras2cd04145:M_R_Ras_likecd04146:RERG_RasL11_likecd04147:Ras_dvacd04148:RGKcd04149:Arf6cd04150:Arf1_5_likecd04151:Arl1cd04152:Arl4_Arl7cd04153:Arl5_Arl8cd04154:Arl2cd04155:Arl3cd04156:ARLTS1cd04157:Arl6cd04158:ARD1cd04159:Arl10_likecd04160:Arfrp1cd04161:Arl2l1_Arl13_likecd04162:Arl9_Arfrp2_likecd04163:Eracd04164:trmEcd04165:GTPBP1_likecd04166:CysN_ATPScd04167:Snu114pcd04168:TetM_likecd04169:RF3cd04170:EF-G_bactcd04171:SelBcd04172:Rnd3_RhoE_Rho8cd04173:Rnd2_Rho7cd04174:Rnd1_Rho6cd04175:Rap1cd04176:Rap2cd04177:RSR1cd08771:DLP_1cd09912:DLP_2cd09913:EHDcd09914:RocCORcd09915:Ragcd11383:YfjPcd11384:RagA_likecd11385:RagC_like33146727975826411994637283961426748465873092849640890464431372154223568051237668024703314672797582641199463728396142674846587309284964089046443137215422356805123766802470
cd04128 Sequence Cluster
cd04128 Sequence Cluster
Sub-family Hierarchy
 cd04128 Branch
 Whole Hierarchy
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Sequence Alignment
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