Conserved Protein Domain Family
Intu_longin_1

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pfam19031: Intu_longin_1 
First Longin domain of INTU, CCZ1 and HPS4
This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Statistics
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PSSM-Id: 436911
Aligned: 37 rows
Threshold Bit Score: 78.4317
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Q803R2        21 LLSFFIYNPKF.[1].PRE.[1].EEEKKILFYHP.[1].EIEKNEKIRNVGLCEAIVQFTRT.[1].CP.[2].PAKSL 81  zebrafish
EEZ98662     264 YPIGILYLNTD.[1].LSE.[2].PEYDDVIYSYP.[1].PFQKSVLCQSRGIFITLNHLIND.[1].TR.[5].TSFFH 328
XP_018331064 248 ELVGVLFLKTE.[1].LKE.[2].PEFEEVLYNFP.[1].PYNKNILCTSRGAFLTLNHLINE.[1].VS.[5].SSINY 312
EDO63998     245 LIFSMIFISKE     YTQ     NDELDVKFCYP     TRENNYLFNSRGSFVTLHSIFNQ.[1].FN.[5].TNLKI 305
Q9VPH0       272 MPFAMLLLPPE.[1].YQH     EQQQDSLYYFP     EIPDNFLFKARGSFLTLHAVLSE     LH.[5].SRLLV 332 fruit fly
XP_001957259 273 QPFAMLLLPPE.[1].YQH     EQQQDSLYYYP     ESPDNFLFKARGSFLTLHAVLSE     LH.[5].SRLLV 333
Q9NQG7        15 WNYFFLYDGSK.[1].KEE.[2].PTRAGICYFYP.[1].QTLLDQQELLCGQIAGVVRCVSD.[1].SD.[1].PPTLV 75  human
Q99KG7        15 WNYFFLYDGSK.[1].KGE.[2].PTRAGICYFYP.[1].QTLLDQQELLCGQLAGVVRCLWD.[1].SG.[1].PPMLI 75  house mouse
XP_004923697   5 MMIVFVYDTQC.[1].TAE.[2].DPINAVLYFHP.[1].WVSDTQRHALAGQVVGAAHCVKT.[1].LS     PPVSI 64 
XP_006137538  15 WNYFFLYDGSK.[1].KEE.[2].PTRAGICYFYP.[1].QTVLDQQELLCGQIAGVVHCITE.[1].SS.[1].PPSLI 75  Chinese soft-shelled...

Q803R2        82 HTQKNRQFFHEPEENYWMVMVVRN.[21].IIDSVYGSVLQQCYSMYKLFNG 148 zebrafish
EEZ98662     329 RDKLCHLTYTQENNKLLLFLFPDS.[ 1].ASVKESVLISNEIKRMFLFMYQ 375
XP_018331064 313 KNQLAHVIYVSCGSKLLLFMFPDK.[ 1].LSVEGSQLVAEEIFRTIEFMYQ 359
EDO63998     306 KNVLYYTTYTVLEDGILLLGFSSK.[ 1].SSVFAVKQKSEQICRFLNALYR 352
Q9VPH0       333 DQVQYHVNYRQLNGFLVLFAYAGG.[ 1].CCAAECSLRSDELIGYIRFSLP 379 fruit fly
XP_001957259 334 EQIPYHVNYRRLNGFLVLFAYAGG.[ 1].CSAAECSLRSDELIDYIRFSLP 380
Q9NQG7        76 RLRKLKFAIKVDGDYLWVLGCAVE      LPDVSCKRFLDQLVGFFNFYNG 121 human
Q99KG7        76 RMRNLKFAIRADGDYLWALGCGVE      ISDASCRQFLDQLIGFFHFYMG 121 house mouse
XP_004923697  65 TLQSGKFIIREYGRYVLAIGSDRN      IPDWVLKNRANLLTSMIKVYHG 110
XP_006137538  76 QLRKLKFAVRVDGEYLWALGCTIE      LPDISCQQFLELLIGLFRFYNG 121 Chinese soft-shelled turtle
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