Conserved Protein Domain Family
Med3
?
pfam11593: Med3, with user query added  
Mediator complex subunit 3 fungal
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator subunit Hrs1/Med3 is a physical target for Cyc8-Tup1, a yeast transcriptional co-repressor.
Links
?
Statistics
?
PSSM-Id: 402954
Aligned: 5 rows
Threshold Bit Score: 312.095
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 

query         73 QNMQSL      LPAPP     TQN.[ 7].MN.[ 5].PPPR.[1].HNM     PSD.[5].GPPAPHM     QNQM 127
Q6FXZ4       234 AQAQNQ.[30].QMQSP     IPA.[12].AM.[10].NPSM.[1].NLN.[2].APN     MGNPNMN.[9].MMSP 334 [Candida] glabrata C...
XP_003669925 241 LLQQQQ      QQQIP.[4].IAT.[ 7].AM      NATP     MMN.[2].SPS.[2].MGTPLNN     GISP 292
P40356       236 VYAQQS      TVQTP     ITA      SM.[ 5].NPTP.[1].MIN.[2].SPT.[2].MGTPLTN     MMSP 282 Saccharomyces cerevi...


query        128 NG.[6].HMPMQGPGPNQLNMTNS.[10].S     MGGYN.[3].PSSQSMP.[ 5].TMSQGQP     MGN.[11]. 204
Q6FXZ4       335 MA.[6].QMFPMQNHNQNGQFMGQ      Q     SPGPN.[9].NGNMNGM.[19].MNLNQIT.[5].SMN.[14]. 429 [Candida] glabrata C...
XP_003669925 293 MG.[5].GFYSQPPGSQSQQFDQQ      M     NNGDH     NTNNNNF      QNMNNIT.[5].SMN.[ 5]. 349
P40356       283 MG     NAYSMGAQNQGGQVSMS      Q.[4].GNGSN.[3].NTNSNNT.[ 5].LNLNNLT.[5].NMS.[ 6]. 347 Saccharomyces cerevi...


query        205 NQGPMMRQQPPS 216
Q6FXZ4       430 QNQNQNQSQNQS 441 [Candida] glabrata CBS 138
XP_003669925 350 QSRMASSSQQYP 361
P40356       348 QQQQQQQQQQQP 359 Saccharomyces cerevisiae S288C
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap