6BJC


Conserved Protein Domain Family
Aurora-A_bind

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pfam09041: Aurora-A_bind 
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Aurora-A binding
The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1.
Statistics
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PSSM-Id: 430383
Aligned: 12 rows
Threshold Bit Score: 110.303
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

6BJC_P         1 MSQV.[1].SSYSYDAPSDFINFSSL.[1].DE.[1].DTQNIDSWFEEKANLENKLLG.[1].N.[1].TGGLFQGKTP 60 
XP_010589897   1 MSQV     TSYSFDAPTDYINFTSL.[1].DE.[1].NNENVDSWFEEKANLENMFPG.[1].N.[1].TGGPFQGKTP 59 
A2APB8         1 MSQV.[1].TTYSFDAPTDFINFSSL.[1].AE.[1].DTENIDSWFDEKANLENKFLR.[1].R.[1].IGEPFQGKNS 60  house mouse
XP_013015445   1 MSQV.[1].NSYSFDAPSNFINFTSL.[1].YD.[1].DTENIDSWFEEKANLENKFFG.[1].N.[1].TGELFQSKTS 60 
XP_013211954   1 MSQV.[1].TTYSFDAPTDFINFTSL.[1].DE.[1].DSENIDSWFDEKANLENKYPG     N.[1].TGELFQSKTS 59 
XP_012310647   1 MSQV.[1].HSYSYDAPSDFINFSSL     DD.[1].DTQNVDSWFEEKANLENKLLG.[1].N.[1].TGGLFQGKTP 59 
XP_012659634   1 MSQV.[1].TSYSYDVPKDFIDFTSL.[1].DE.[1].DTENIDSWFEEKANLENKLLG.[1].N.[1].TGGPFQSKTP 60 
XP_012044402   1 MSQV.[1].TSYSYDAPTDFINFSSL.[1].DE.[1].DTQHIDSWFDEKANLENKFPG.[1].D.[1].TGGLFQGKTP 60 
XP_010720927   1 MSRS.[1].SRYSFDVPNPCINFATL.[1].DD     DVHNADSWFDQQANLENIPPA.[1].N     LAKVLQNSPA 58 
XP_007474524   1 MSQS.[1].ASYSFDAPTAFINFTSF.[1].NE     DVCNVDSWFEERANLENKPPE.[1].D.[1].VPGPSYRKTP 59 
XP_002710892   1 MSQV.[1].SSYTFDAPTDFINFTSL.[1].DE.[1].DSENVDLWFEEKANLENKFPG.[1].N.[1].TGELLHGKTT 60 
XP_025841905   1 MSQV.[1].TSYSYDAPTDFINFTSL.[1].DE.[1].DAQNIDSWFEEKANLENKFSG.[1].N.[1].IAGLFQDKTP 60  red fox

6BJC_P        61 LRKANLQQ 68 
XP_010589897  60 LRKGNRQQ 67 
A2APB8        61 LRKAKLQQ 68  house mouse
XP_013015445  61 LKKANLQQ 68 
XP_013211954  60 VKKGNLQQ 67 
XP_012310647  60 LRKTNLQQ 67 
XP_012659634  61 LRKSNLQQ 68 
XP_012044402  61 LRKANLHQ 68 
XP_010720927  59 FSKPLILS 66 
XP_007474524  60 LRKTHVPQ 67 
XP_002710892  61 LRKANLQQ 68 
XP_025841905  61 LRKPNPQQ 68  red fox
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