Conserved Protein Domain Family
FAST_1
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pfam06743: FAST_1 
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 461999
Aligned: 111 rows
Threshold Bit Score: 46.7095
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

EDV27484     373 LCQLIYSLGKMNFKLE.[4].K     KFFPIVIQRLEDLMK.[3].RYTPKF.[3].VISATWSLIIMEQFPPRLISKI 442 
EFN68880     532 LSSMLTPFGLLNIQPP     D.[2].EFWKKFDEVISARFA     DLKLND     VLDIFLSCMYLEKYPVKYLDRV 593 
EDS40567     402 LKAFLCPYGYLDFHPL     N.[2].KFFETLDMYLDLNFT     KIHPND     IIHIMFCYVCLERYPLPFVNRI 463 
EDO63502     440 LKALFCPFAYLDFVPT     N.[2].KFFDTINMFLDLHFA     KIRPTD     TIDIMFAYICLERFPLNFVNRI 501 
EEN58993     397 IASQIVPYGQLNYLPP     N.[2].RFLEKVEQLLMARYH     LFPLEM     MVNMLFSFACVGRIPLNFVNRV 458 
XP_013004725 428 ISELIEPFGKLNHLPP     N.[2].AFFRKLENVLFTNIN     HFPPKT     LLRVLHSCSLIGCHPVNFMAKI 489 
XP_003505824 406 IAESIEPFGKLNYLPP     N.[2].ALFRKLESVLVARFH     HFPPQL     LLKLLHSCSLIECHPVNFMSKI 467 
XP_005450460 366 IAKQIVAMGRLNYLPQ     C.[2].QMFKKLESILSERFS     QFQPRS     LVDVMHACIHLERFPLNYMTKV 427 
XP_007240095 393 VSQLVAALGVVGYVPK     E.[2].RLFRKLESVIDARFS     QFQPKS     LLELLHACTLLQRYPLNFVSKV 454 
XP_026823036 416 FRDLFWPFGQLNYKPK     S.[2].EFWIKVENIMNKEFY     NFKTQD     TIDILLSCVYLEKHPLNFVHRI 477  corn leaf aphid


EDV27484     443 LSDQFIEDAT 452 
EFN68880     594 FSSYLVNRLE 603 
EDS40567     464 FNPYFLDVLH 473 
EDO63502     502 FNPYFLDVLH 511 
EEN58993     459 CSPYAELQLE 468 
XP_013004725 490 FSPFFLQQLQ 499 
XP_003505824 468 FSPFFLQRLQ 477 
XP_005450460 428 FSPHFLQRLQ 437 
XP_007240095 455 LSPYFLQQLH 464 
XP_026823036 478 FNTSFLHHLF 487  corn leaf aphid
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