Conserved Protein Domain Family
CYP_GliC-like
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cd20615: CYP_GliC-like 
cytochrome P450 monooxygenases similar to gliotoxin biosynthesis protein C
This subfamily is composed of cytochrome P450 monooxygenases that are part of gene clusters involved in the biosynthesis of various compounds such as mycotoxins and alkaloids, including Aspergillus fumigatus gliotoxin biosynthesis protein (GliC), Penicillium rubens roquefortine/meleagrin synthesis protein R (RoqR), Aspergillus oryzae aspirochlorine biosynthesis protein C (AclC), Aspergillus terreus bimodular acetylaranotin synthesis protein ataTC, Kluyveromyces lactis pulcherrimin biosynthesis cluster protein 2 (PUL2), and Aspergillus nidulans aspyridones biosynthesis protein B (ApdB). The GliC-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410708
Aligned: 23 rows
Threshold Bit Score: 458.674
Created: 15-Aug-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                                                         #   #      #                
E9RCR4     81 GPIYQIWSG.[2].PEIVLT.[1].PTHAVQFFR.[20].LGVCVGLLSGTDWKRVRQQVEDGF.[1].RPTAARYTGDL 163 Aspergillus fumigatus A...
EAU35087   11 EEPYLVHNG.[2].RELVVT.[1].PEHVQEFYR.[21].LGRSAGVQGGRKWVAIRAHFDPEF.[1].HSSSVYMSDIF 94  Aspergillus terreus NIH...
EEP81630   36 DEPYILRNG.[2].REVVIH.[1].AEHVREFLR.[21].LGQCVGALSGEPWRAVRRYFDPAY.[1].HNAGLGLIPSF 119 Uncinocarpus reesii 1704
CAH01908   85 GDLYLQRSG.[2].KEIVLT.[1].PKQLMEYYK.[21].LGECLGFQNGSEWLSMRKVFDSFF.[1].HKAAVENFPVM 168 Kluyveromyces lactis
EAL92287  113 GKTYRIWAA.[2].PEVVIT.[1].PKDVEVLYQ.[20].LGSGLGLINGTRWSTLRKTLDPMF.[1].HRAALQYLRDS 195 Aspergillus fumigatus A...
EED49867   84 SEPYLVRNG.[2].KELVIF.[1].PEHLQEFHR.[21].LGQCVGQLGGTKWKLARSHMDPEF.[1].YRASRSMMKRF 167 Aspergillus flavus NRRL...
ABV48719   78 GAVYRIWSG.[2].PEIVLT.[1].PEDVKTFYI.[20].LGDCMGLINGERWKRTRLEFNSYF.[1].NRAITEFSPQM 160 Hypocrea virens
Q5ATH2     84 DEPFIIRNG.[2].RELVVT.[1].PEHIYDFYK.[ 8].LGHAVGALAGERWSMIRRYFDPAF.[1].FQSARQAIPEL 154 Aspergillus nidulans FG...
B8NJG8     84 SEPYLVRNG.[2].KELVIF.[1].PEHLQEFHR.[21].LGQCVGQLGGTKWKLARSHMDPEF.[1].YRASRSMMKRF 167 Aspergillus flavus NRRL...
Q6CSN2     85 GDLYLQRSG.[2].KEIVLT.[1].PKQLMEYYK.[21].LGECLGFQNGSEWLSMRKVFDSFF.[1].HKAAVENFPVM 168 Kluyveromyces lactis NR...


Feature 1                           #                                                         
E9RCR4    164 VFLAR.[25].AKTLQFYPFLSVAQILFGR.[ 8].LTTLAPLREELFKEVIRGG.[6].APWFKSRG.[3].LNEFQTQ 263 Aspergillus fumigatus A...
EAU35087   95 ATEIS.[24].AEACHFLPFRLIALTAYGD.[ 9].LVHLNDLHEPLMLDAIFGK.[6].FNFLPTEF.[3].LKKFERS 194 Aspergillus terreus NIH...
EEP81630  120 QAEVV.[22].PTSCKLLPLRVIPLSFYGE.[ 9].LLRISKLQGQALKYAVTGR.[6].YNLLPTSS.[3].LEQYHRD 217 Uncinocarpus reesii 1704
CAH01908  169 IDYIS.[16].LQLVSDLPFTCIAKYLYGS.[10].LKDLIPMHTELMHYSFLTV.[6].FQYFPSKK.[3].VSQFQRQ 261 Kluyveromyces lactis
EAL92287  196 LDAGA.[29].TQALQRYPFFEVASMFYGK.[ 8].LWDLGRRYSEVFAAIVSGG.[6].TRYLNTKA.[3].ARDYQKA 299 Aspergillus fumigatus A...
EED49867  168 SQEID.[24].KKRCKDLSLRSIAISIYGE.[ 9].LSTMNELHEKIIFVAFLNK.[6].YNKLPTAE.[3].MDSFQTQ 267 Aspergillus flavus NRRL...
ABV48719  161 EQGAA.[18].AGNISRFPFMTTAEHIYGP.[ 8].LWSLGQRSLGLMGKVLSGG.[6].CQYLRPGT.[3].LKKFNYD 253 Hypocrea virens
Q5ATH2    155 SASID.[21].KKPCRFLPLRLAAEFVYGE.[ 9].LLDLNVLHEVILHDVIANK.[6].GCWFDRAA.[3].MEEFRSR 251 Aspergillus nidulans FG...
B8NJG8    168 SQEID.[24].KKRCKDLSLRSIAISIYGE.[ 9].LSTMNELHEKIIFVAFLNK.[6].YNKLPTAE.[3].MDSFQTQ 267 Aspergillus flavus NRRL...
Q6CSN2    169 IDYIS.[16].LQLVSDLPFTCIAKYLYGS.[10].LKDLIPMHTELMHYSFLTV.[6].FQYFPSKK.[3].VSQFQRQ 261 Kluyveromyces lactis NR...


Feature 1                             ##  ##  ##  #                                           
E9RCR4    264 WEQFVEDAY.[27].KRECLQTLDESLYANLDVTTHALSWNVLLLAEN.[2].AQTELRQEVL.[17].DDTFLAACILE 372 Aspergillus fumigatus A...
EAU35087  195 WERLNDEVL.[ 2].AREFLQTMYELLYTNIDVTSTVTSFLLLNISAN.[2].FQSKLREEIQ.[16].KDTLLHYAVME 277 Aspergillus terreus NIH...
EEP81630  218 WRKFNMGIL.[ 2].ARNYLQTIDEMIFTNIDITGNVIAFMFTQLAKH.[2].FQQKLYEEII.[16].QSTLLHYLCLE 300 Uncinocarpus reesii 1704
CAH01908  262 FIDLSLKQV.[25].FNNWIQTIDEILFANIEVTSTVMAWALVEMGSN.[2].EQNRLRCEIL.[24].TDTYLQYCVWE 375 Kluyveromyces lactis
EAL92287  300 WRDFNREIY.[25].PNEVTDTIAESTFANLDIVTHVISSCIILLADS.[2].VQNDLLQEME.[12].KDTLLHYCLLE 401 Aspergillus fumigatus A...
EED49867  268 WKAFNLAQI.[25].LPEFLQSLDEMLFTNIDITGSILALIFQHLAKD.[2].MQKKLRAEIS.[16].QNTLLHFSLLE 373 Aspergillus flavus NRRL...
ABV48719  254 WTAFNEQIY.[25].KQELIQTMSEILFANLDVSTHVLGWLIIFVAQN.[2].VQEQLRKEIT.[12].KDTLLHFCYLE 355 Hypocrea virens
Q5ATH2    252 WMEFNLGII.[25].LEEFLHTLDEILFANVDVSSAVLGTLFEHLAVN.[2].FQQKLRAEIE.[28].QDTLMNFAVME 369 Aspergillus nidulans FG...
B8NJG8    268 WKAFNLAQI.[25].LPEFLQSLDEMLFTNIDITGSILALIFQHLAKD.[2].MQKKLRAEIS.[16].QNTLLHFSLLE 373 Aspergillus flavus NRRL...
Q6CSN2    262 FIDLSLKQV.[25].FNNWIQTIDEILFANIEVTSTVMAWALVEMGSN.[2].EQNRLRCEIL.[24].TDTYLQYCVWE 375 Kluyveromyces lactis NR...


Feature 1      #             # #                          #                               ### 
E9RCR4    373 SARLRPI.[ 2].FSNPESAPEDLYVD.[1].YLIPANTNVIVDAQAIN.[ 7].NGTQYNPRRF.[ 8].RHNMWRFGF 447 Aspergillus fumigatus A...
EAU35087  278 SLRMSPA.[ 2].FSLPEKTATDKIIG.[1].YHIPAGTPTIIDWKRLN.[ 8].DSEVFCPERF.[ 8].RYAFLRFGI 353 Aspergillus terreus NIH...
EEP81630  301 SVRLHPA.[ 2].FSVPEYTAIDKVIG.[1].YKIPAQTPVIIDVRRLN.[ 8].DGGEFRPERF.[ 8].RYGFMRFGV 376 Uncinocarpus reesii 1704
CAH01908  376 TLRMHPL.[ 2].FSFPEISSETLFID.[1].IRISPNTPIVVDQYQIN.[14].FGKKFAPSRF.[ 8].LYSQVTFGA 457 Kluyveromyces lactis
EAL92287  402 SLRLRPV.[13].FTFPENPPREKILG.[1].FVVPKDTTIIVDAFAIN.[ 8].DNRAYRPSRF.[ 8].RYNLATFGY 488 Aspergillus fumigatus A...
EED49867  374 SIRVTPA.[ 2].FTLPECNASPKRIG.[1].FHIPAHTPTIVDVNRLN.[ 8].EADAFRPERF.[ 8].RFGFVRWGI 449 Aspergillus flavus NRRL...
ABV48719  356 SLRLRPF.[ 2].FTIPETSPMAKVLG.[1].YRIPKNTGVVVDTLAIN.[ 8].NSRDFNPYRF.[13].RYNLFTFGF 436 Hypocrea virens
Q5ATH2    370 AMRLSPA.[ 7].FSLPECTAVPKEIG.[1].YRVPARCPVVIDAKRLN.[ 8].DGDTYRPERF.[ 8].RYGFMRFGV 450 Aspergillus nidulans FG...
B8NJG8    374 SIRVTPA.[ 2].FTLPECNASPKRIG.[1].FHIPAHTPTIVDVNRLN.[ 8].EADAFRPERF.[ 8].RFGFVRWGI 449 Aspergillus flavus NRRL...
Q6CSN2    376 TLRMHPL.[ 2].FSFPEISSETLFID.[1].IRISPNTPIVVDQYQIN.[14].FGKKFAPSRF.[ 8].LYSQVTFGA 457 Kluyveromyces lactis NR...


Feature 1           #####  ##                                          
E9RCR4    448 G.[1].RQCLGKHIGERMLKAIVAEIIRQYV.[10].NDLQEDSW.[1].GLPATRI 500 Aspergillus fumigatus Af293
EAU35087  354 G.[1].RRCMGQNIAIVMLKMAVIEVLKRYS.[10].NDRFTVTS.[1].GEIEFMS 406 Aspergillus terreus NIH2624
EEP81630  377 V.[1].GRCLGKHMADVLMKIAIITILKQYR.[ 4].EKNIGVKE.[1].DLAFIQR 423 Uncinocarpus reesii 1704
CAH01908  458 G.[1].RKCLGRNFAELLIKSELAYILSKYK.[ 6].VEFSKDTF.[1].VQPKTKI 506 Kluyveromyces lactis
EAL92287  489 G.[1].RKCLGQHIADKIVKAVVYHLFSKYR.[ 6].QAVEGDFK     VDKTSWV 536 Aspergillus fumigatus Af293
EED49867  450 G.[1].DKCLGKNMAEVILKLAILAVTDKYT.[10].GEKSEAGF.[1].INRDVEV 502 Aspergillus flavus NRRL3357
ABV48719  437 G.[1].RKCLGQHFAEAMMKQFLCKLLEGYE.[ 5].TEIRKGTE.[2].FSRDTWV 485 Hypocrea virens
Q5ATH2    451 G.[3].GRCLGKHLADTLFKLTLIAVIERYS      LHSVHDGP.[2].ELREVVV 496 Aspergillus nidulans FGSC A4
B8NJG8    450 G.[1].DKCLGKNMAEVILKLAILAVTDKYT.[10].GEKSEAGF.[1].INRDVEV 502 Aspergillus flavus NRRL3357
Q6CSN2    458 G.[1].RKCLGRNFAELLIKSELAYILSKYK.[ 6].VEFSKDTF.[1].VQPKTKI 506 Kluyveromyces lactis NRRL Y-1140

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