3H6Z,4C5E


Conserved Protein Domain Family
MBT_dSfmbt_rpt4
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cd20128: MBT_dSfmbt_rpt4 
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fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)
dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.
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Statistics
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PSSM-Id: 439118
Aligned: 3 rows
Threshold Bit Score: 165.982
Created: 8-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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methyllysine
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:methyllysine peptide binding site [polypeptide binding site]
Evidence:
  • Comment:MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine.
  • Structure:3H6Z; Drosophila Melanogaster Sfmbt in complex with peptide Rhr(Me)kVlr through its fourth MBT repeat; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                  #  #  # #                   #  #      #                             
3H6Z_A     375 HGFEVGMSLECADLMDPRLVCVATVARV.[1].GRLLKVHFDGW.[2].EYDQWLDC.[1].SADIYPVGWCVL.[1].N 439  fruit fly
4C5E_A     376 HGFEVGMSLECADLMDPRLVCVATVARV.[1].GRLLKVHFDGW.[2].EYDQWLDC.[1].SADIYPVGWCVL.[1].N 440  fruit fly
Q9VK33     905 HGFEVGMSLECADLMDPRLVCVATVARV.[1].GRLLKVHFDGW.[2].EYDQWLDC.[1].SADIYPVGWCVL.[1].N 969  fruit fly


Feature 1             
3H6Z_A     440 HKLEGPP 446  fruit fly
4C5E_A     441 HKLEGPP 447  fruit fly
Q9VK33     970 HKLEGPP 976  fruit fly

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