Conserved Protein Domain Family
bHLH_E-protein_E2A_TCF3
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cd18944: bHLH_E-protein_E2A_TCF3 
basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar proteins
E2A, also termed Class B basic helix-loop-helix protein 21 (bHLHb21), or immunoglobulin enhancer-binding factor E12/E47, or immunoglobulin transcription factor 1, or Kappa-E2-binding factor, or transcription factor 3 (TCF-3), or transcription factor ITF-1, is a bHLH transcriptional regulator involved in the initiation of neuronal differentiation.
Links
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Statistics
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PSSM-Id: 381514
Aligned: 6 rows
Threshold Bit Score: 151.718
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on structure evidence that Mus musculus E47 (2QL2)-NeuroD1 complex binds DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1          #   # ### #    #                        ##                                  
P15923       549 ERRVANNARERLRVRDINEAFKELGRMCQLHLN.[1].EKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRRE 622 human
NP_989817    564 ERRVANNARERLRVRDINEAFKELGRMCQLHLN.[1].EKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRRE 637 chicken
Q01978       555 ERRVANNARERLRVKDINEAFKELGRMCQLHLN.[1].EKPQTKLLILHQAVSVILSLEQQVRERNLNPKAACLKRRE 628 African clawed frog
XP_014341569 529 ERRVANNARERLRVRDINEAFKELGRMCQLHLN.[1].DKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRRE 602 coelacanth
KQK78114     439 ERRVANNARERLRVRDINEAFKELGRMCQLHLN.[1].EKPQTKLLILHQAVSVILNLEQQVRDEALSLEDKDLRDRE 512 blue-fronted amazon
NP_571169    488 ERRMANNARERLRVRDINEAFKELGRMCQLHLS.[1].EKPQTKLLILHQAVNVILNLEQQVRERNLNPKAACLKRRE 561 zebrafish

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