Conserved Protein Domain Family
RING-HC_RNF169
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cd16551: RING-HC_RNF169 
RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
RNF169 is an uncharacterized E3 ubiquitin-protein ligase paralogous to RNF168. It functions as a negative regulator of the DNA damage signaling cascade. RNF169 recognizes polyubiquitin structures but does not itself contribute to double-strand break (DSB)-induced chromatin ubiquitylation. It contributes to regulation of the DSB repair pathway utilization via functionally competing with recruiting repair factors, 53BP1 and RAP80-BRCA1, for association with RNF168-modified chromatin independent of its catalytic activity, limiting the magnitude of the RNF8/RNF168-dependent signaling response to DSBs. RNF169 contains an N-terminal C3HC4-type RING-HC finger and a C-terminal MIU (motif interacting with ubiquitin) domain.
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Statistics
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PSSM-Id: 438213
Aligned: 5 rows
Threshold Bit Score: 63.3323
Created: 30-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1            #  #               # #  #  #          #  #           
Q8NCN4         65 ESGCAGCLEPPG.[1].AAALPCGHSLCRGCAQRA.[6].GCPRCRARGPGWARRR 117  human
F1MRW8         46 ESDCAGCLETPG.[1].AAALPCGHSLCRGCAQRA.[6].CCPRCRARGAGWARRR 98   cattle
NP_001088240   13 SLSCIMCQDVPR.[1].PVTLSCGHCLCRGCLERA.[8].TCPKCRPPPAVPTPDT 67   African clawed frog
XP_005848472   28 ELTCVICYEVSV.[1].PSTLPCGHTACRGCFNRA.[8].KCPSCRAPLPIGMPAL 82  
PSC70441       57 KFTCCLCLDTAV.[1].PASLPCGHTTCRACINRL.[8].ACPACSAPLPLNLPSL 111  Micractinium conductrix

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