Conserved Protein Domain Family
PHD1_BPTF
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cd15559: PHD1_BPTF 
PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
BPTF, also termed nucleosome-remodeling factor subunit BPTF, or fetal Alz-50 clone 1 protein (FAC1), or fetal Alzheimer antigen, functions as a transcriptional regulator that exhibits altered expression and subcellular localization during neuronal development and neurodegenerative diseases such as Alzheimer's disease. It interacts with the human orthologue of the Kelch-like Ech-associated protein (Keap1). Its function and subcellular localization can be regulated by Keap1. Moreover, BPTF is a novel DNA-binding protein that recognizes the DNA sequence CACAACAC and represses transcription through this site in a phosphorylation-dependent manner. Furthermore, BPTF interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity, which has been implicated in gene regulation in neurodegeneration. Some family members contain two or three plant homeodomain (PHD) fingers, which may be involved in complex formation with histone H3 trimethylated at K4 (H3K4me3). This family corresponds to the first PHD finger.
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Statistics
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PSSM-Id: 277034
Aligned: 14 rows
Threshold Bit Score: 81.308
Created: 9-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1          #  #        #  #    #  #              #  #
Q12830        392 HCRVCHKLGDLLCCETCSAVYHLECV.[5].EVPEDEWQCEVC 434  human
Q9W0T1        341 HCRVCHRLGDLLCCETCPAVYHLECV.[5].DVPTEDWQCGLC 383  fruit fly
XP_003723643  393 HCRSCHKLGDLICCETCSAVYHLECV.[3].EVPEEDWMCSVC 433  purple urchin
XP_002416180  323 HCRVCHKLGDLLCCETCPAVFHLACL.[5].DVPTEDWICTVC 365  black-legged tick
EFX88281      361 HCRVCHKVGDLLCCETCPAVYHLHCL.[5].HVPNEDWQCPIC 403  common water flea
AEI28455      108 HCRVCHKLGDLLCCETCSAVYHLECV.[5].EVPEDEWQCEVC 150  dark-spotted frog
EKC32268      322 HCRACHKLGDLLCCETCSAVYHLACV.[5].EVPEEDWVCTIC 364  Pacific oyster
CAG06119      260 HCRVCHRLGDLLCCETCSAVYHLECV.[5].EVPEDEWQCEVC 302  spotted green pufferfish
ELT92003      324 HCRNCYRLGDLLCCETCSAVYHLGCV.[5].NVPDDDWLCNIC 366  Capitella sp. I Grassle & Grassle, 1976
XP_006824287  316 HCRNCHKMGDLLCCETCSAVYHLECV.[5].EVPEEDWVCEIC 358  Saccoglossus kowalevskii

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