2HW6


Conserved Protein Domain Family
STKc_Mnk1

?
cd14174: STKc_Mnk1 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 271076
Aligned: 4 rows
Threshold Bit Score: 636.302
Created: 31-Aug-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                 #####   #                # #                                 #         
2HW6_A        12 DMYKLTSELLGEGAYAKVQGAVSLQ.[1].GKEYAVKIIEKQAGHSRSRVFREVETLYQCQ.[1].NKNILELIEFFEDD 83  human
Q9YGW0        34 DLYRLTDELLGEGAYAKVQGCVSLQ.[1].GKDYAVKIVEKKAGHSRSRVFREVETLYQCQ.[1].NKNILELIEFCEDD 105 African clawed frog
NP_001108211  93 DLYRLTDELLGQGAYAKVQGCVSLQ.[1].GTEYAVKIIEKNAGHSRSRVFREVETLYQCQ.[1].NKNILELIQFFEDD 164 zebrafish
XP_001235171  77 DLYKLTAELLGEGAYAKVQGAVSLQ.[1].GKEYAVKIIEKNAGHSRSRVFREIETLYQCQ.[1].NKNILELIEFFEDD 148 chicken

Feature 1                 ####   # #                                       ## # ## #             
2HW6_A        84 .[2].FYLVFEKLQGGSILAHIQKQK.[1].FNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCE.[3].KVSPVK 154 human
Q9YGW0       106 .[2].FYLVFEKLLGGSILSHIQKRK.[1].FNEREASKVVKDIASALDFLHTKGIAHRDLKPENILCE.[3].KVSPVK 176 African clawed frog
NP_001108211 165 .[2].FYLVFEKLRGGSILTHIQSRK.[1].FDEREASRVVRDIANALDFLHNKGIAHRDLKPENILCE.[3].KVSPVK 235 zebrafish
XP_001235171 149 .[2].YYLVFEKLRGGSILAHIQKRK.[1].FNEREASKVVRDIASALNFLHTKGIAHRDLKPENILCE.[3].KVSPVK 219 chicken

Feature 1         ##  #                     ##### #                                              
2HW6_A       155 ICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFT.[2].ATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG 231 human
Q9YGW0       177 ICDFDLGSGVKLNSACTTITTPELTTPCGSAEYMAPEVVEVFT.[2].ATFYDKRCDLWSLGVILYIMLSGYPPFVGNCG 253 African clawed frog
NP_001108211 236 ICDFDLGSGVKLNSACTPITTPELTTPCGSAEYMAPEVVEVFT.[2].ASFYDKRCDLWSLGVILYILLSGSPPFTGHCG 312 zebrafish
XP_001235171 220 ICDFDLGSGVKLNSACTPITTPELTTPCGSAEYMAPEVVEVFT.[2].ATFYDKRCDLWSLGVILYIMLSGYPPFVGNCG 296 chicken

Feature 1                                                                                 
2HW6_A       232 .[1].DCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 human
Q9YGW0       254 .[1].DCGWDRGEVCRVCQNKLFESIQEGKYEFPEKDWSHISISAKDLISKLLVRDAKERLSAFQVLQHPWLQ 322 African clawed frog
NP_001108211 313 .[1].NCGWERGETCRSCQNNLFERIQEGKYEFSDGVWTQISADAKDLISRLLVRDATLRLSAAQVLQHPWVQ 381 zebrafish
XP_001235171 297 .[1].DCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWSHISSEAKDLISKLLVRDAKERLSAAQVLEHSWVQ 365 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap