2E5G,5WU6


Conserved Protein Domain Family
RRM_TUT1
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cd12279: RRM_TUT1 
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RNA recognition motif (RRM) found in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins
This subfamily corresponds to the RRM of Star-PAP, also termed RNA-binding motif protein 21 (RBM21), which is a ubiquitously expressed U6 snRNA-specific terminal uridylyltransferase (U6-TUTase) essential for cell proliferation. Although it belongs to the well-characterized poly(A) polymerase protein superfamily, Star-PAP is highly divergent from both, the poly(A) polymerase (PAP) and the terminal uridylyl transferase (TUTase), identified within the editing complexes of trypanosomes. Star-PAP predominantly localizes at nuclear speckles and catalyzes RNA-modifying nucleotidyl transferase reactions. It functions in mRNA biosynthesis and may be regulated by phosphoinositides. It binds to glutathione S-transferase (GST)-PIPKIalpha. Star-PAP preferentially uses ATP as a nucleotide substrate and possesses PAP activity that is stimulated by PtdIns4,5P2. It contains an N-terminal C2H2-type zinc finger motif followed by an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a split PAP domain linked by a proline-rich region, a PAP catalytic and core domain, a PAP-associated domain, an RS repeat, and a nuclear localization signal (NLS).
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Statistics
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PSSM-Id: 409721
Aligned: 8 rows
Threshold Bit Score: 120.215
Created: 16-Sep-2011
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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2E5G_A          7 GLRSVFVSGF.[3].VDSAQLSEYFL.[1].FGPVASVVMDK.[3].VFAIVEMG.[2].GAREAVLSQ.[2].HSLGGH 72   human
NP_001025359   52 EENSVFVSGF.[3].TSQTELKEYFQ.[1].FGLVTDVIMDK.[3].VYAIVEFS.[2].QDVQTTLAQ.[2].HQLNGL 117  zebrafish
A9JTS5         63 QERSVYVSNF.[3].TSEEQLRDVFQ.[1].ISPVRNIVMDK.[3].LYAIVEFE.[2].DGMCAALEE.[2].IKLSGK 128  western clawed frog
XP_002130666   52 AVRSVYVSGL.[4].AAELSLADYFS.[1].FGAVKKVTIDK.[3].HYAIIEMD.[2].ETVDKILEK.[2].HTILGV 118  Ciona intestinalis
5WU6_A          2 GLRSVFVSGF.[3].VDSAQLSEYFL.[1].FGPVASVVMDK.[3].VFAIVEMG.[2].GAREAVLSQ.[2].HSLGGH 67   human
EMP38486       51 ELRSVFVSGF.[3].TSASELSEYFQ.[1].FGDVASVVMDK.[3].VYAIVELQ.[2].EVMEKVLAQ.[2].HCLGGQ 116  Green sea turtle
XP_007907613   29 EENSVFVSGF.[3].TPELELSDYFQ.[1].FGTVASIIMDK.[3].IYAIIQMD.[2].EEVKRVLSV.[2].HCMNGQ 94   elephant shark
XP_006000217   53 EERSVFVSGF.[3].TSDLEITGHFQ.[1].YGSVSSVIMDK.[3].VYAIVELD.[2].ETLQKVLSE.[2].HCMNGQ 118  coelacanth


2E5G_A         73 RLRVRPRE 80   human
NP_001025359  118 KLRVKPRE 125  zebrafish
A9JTS5        129 RLRVKPRE 136  western clawed frog
XP_002130666  119 NVDVRLRE 126  Ciona intestinalis
5WU6_A         68 RLRVRPRE 75   human
EMP38486      117 RLRVKPRE 124  Green sea turtle
XP_007907613   95 KLRVKARE 102  elephant shark
XP_006000217  119 RLQVKPRE 126  coelacanth
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