Conserved Protein Domain Family
CYP52

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cd11063: CYP52 
cytochrome P450 family 52
Cytochrome P450 52 (CYP52), also called P450ALK, monooxygenases catalyze the first hydroxylation step in the assimilation of alkanes and fatty acids by filamentous fungi. The number of CYP52 proteins depend on the fungal species: for example, Candida tropicalis has seven, Candida maltose has eight, and Yarrowia lipolytica has twelve. The CYP52 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410686
Aligned: 57 rows
Threshold Bit Score: 441.996
Created: 3-Apr-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                              #   #      #  
P30611               88 HVHTFVTKVL.[1].NELIMT.[1].DPENIKVLLRFPVFDKFDY.[9].SLGMGIFTLEGENWKATRSVLRNMFDR 160 Candida tropicalis
AAL67906            101 LGQTFEVYIL.[1].DSNYVT.[1].DANVIKTILATDFDNFVKG.[9].VLGTGVFNSDGEMWKFHRSMTRPFFTR 173 Phanerochaete ch...
EAL85431            116 PFQTLEVRLG.[1].QTVIVS.[1].DPQVVKALLTTQFGDFGKG.[9].FLGDAIFTTDGDKWHASRALIRPMFTP 188 Aspergillus fumi...
EAA59226            108 DKKTVELDAG.[2].SRIIFT.[1].DPENIKAILTGQFSDYGKG.[9].FLGDSIFVTDGEQWSASRHLIRPMFVR 181 Aspergillus nidu...
EAA60936            403 SPNCVESNIF.[2].FRVIQT.[1].EPEHLKAVLTGKFADFGKG.[9].FLGDSIFTTDGKEWQGSRNLIRPMFIK 476 Aspergillus nidu...
EAL22122            109 YGGTYNTRVL.[1].EDQIIS.[1].DPKVIKHVLIDDFDNFVKG.[9].FLGDGIFNSDGDNWKFHRSFMRPFFQP 181 Cryptococcus neo...
EAA28794             87 GGYTGEVRLV.[1].HRIIFT.[1].EPENMKAILATQFEDYGKG.[9].FLGDSIFTTDGDLWHASRQLIRPQFIK 159 Neurospora crass...
EEQ39970             80 GADTLDFTGF.[1].SKIFFT.[1].NPHNVKSLFATNFDDWSIG.[8].FLGVGVFVTDGEVWKHSRTMLKPQFSR 151 Clavispora lusit...
EAL86290             80 YGDTYASRIL.[1].QRVYFT.[1].DPRNIRHVLINRFSDFDAS.[9].ITPHGIFAVDGAEWKEARSLYADIFSA 152 Aspergillus fumi...
WGS:AACS:CC1G_05498 118 YGHTFELRLP.[1].ENQIWT.[1].EPEHVKAMLATQFQNFEKG.[9].FLGTGVFNSDGDMWKFHRAITRPFFTR 190 Coprinopsis cine...

Feature 1                                                            #                             
P30611              161 .[5].VHDFEPHFKTLQKRIDGKVGYFD.[ 5].LKLGLELSIEFIFGQVVS.[ 5].YDDFTQAWDRCQDYMML 233 Candida tropicalis
AAL67906            174 .[5].FDLFDRHADATMAKMKARLAEGF.[ 8].SRFTLDSATEFLFGQCTT.[ 4].TEDFARAFAEAQDAVSF 248 Phanerochaete chry...
EAL85431            189 .[5].LSTFERHVQKLLRILESPRHERQ.[ 8].LRLTMDIATDFLLGQSVD.[ 5].THRFSAAFADVQRIQSW 264 Aspergillus fumiga...
EAA59226            182 .[5].TEIFEKHVQHLIPLLAGNNESKI.[ 7].FRYTLDAATNYLLGQGTD.[ 5].ETEFAEAFRYVQRRQAQ 256 Aspergillus nidula...
EAA60936            477 .[5].LDIFERKTQTMLSLYSPCGEPTD.[ 5].YRMTLDAITEFLLGKGIN.[ 5].QADFALAFADVQRIQTL 549 Aspergillus nidula...
EAL22122            182 .[4].PLHFSTNVQNFFAKLPSYGKVFD.[ 5].GQLALELAIMWLCGEDMS.[15].KGEISWAMTEAQKIVGK 263 Cryptococcus neofo...
EAA28794            160 .[5].LQCFENHMQMLFRTIANGGALNG.[21].FRYTLDAATDFLLGKDIK.[ 5].VQPFADAFQEVQRVQIV 248 Neurospora crassa ...
EEQ39970            152 .[5].VHSVESHYKLFAQHIRSYRGQEF.[ 6].MKLTMDASSEFLFGESIH.[18].KKELAEDLSFLQTYLMF 238 Clavispora lusitan...
EAL86290            153 .[6].LQLQEDGFQGLIKQIPRGQAMDL.[ 4].LKLVLDVNSAFAMGTGLD.[ 9].KKEVAEALMYAKKIMAR 229 Aspergillus fumiga...
WGS:AACS:CC1G_05498 191 .[5].FDIFDKHAAQTLELARARLAEGY.[ 8].ARFTLDSAAQFLFGEKID.[24].SNIFVNAFLSGLHGVTM 285 Coprinopsis cinere...

Feature 1                                                                          ##  ##  ##  #        
P30611              234 .[13].WRYKQSNQIVQAFCDYLVQKS.[ 8].FVFVHQLAKHT.[1].NKTFIRDQALSLIMASRDTTAELMAFTILEL 318 Candida tropi...
AAL67906            249 .[ 5].WLWPDAVARADKIKRENGGRV.[10].ETLLDHLVNVV     QTKILHDEVLNIMIAGRDTTGGTLTSAVYFL 326 Phanerochaete...
EAL85431            265 .[13].AKYYEGLKTINSFVDPFITRT.[17].YNFLEGLATFT.[1].DPKVIRDQLISVLLAARDTTAATLARTLYEL 358 Aspergillus f...
EAA59226            257 .[13].TEFRRQLKVMDDFIKPYIDRV.[15].DTFLHALARFT.[1].DRRTLRDQLVAILLAGRDTTAATLSFCLFEL 348 Aspergillus n...
EAA60936            550 .[13].GRYNQGLKVINDFVWPFVHDT.[14].FTFLHALANYT.[1].SPKTIRDQVVSILLAGRDTTAATLSWAFYEL 640 Aspergillus n...
EAL22122            264 .[15].DPLERPMKVIRAFFRPIISRA.[15].VYMIDRLVEAT.[1].DIKLVEDQLINVLLASRDTLASLLTFSVYAI 357 Cryptococcus ...
EAA28794            249 .[13].KTFWEGLKVIDETINFYIDRA.[17].YTFLHALAGFT.[1].NRQVLHDQLMAVLLAGRDTTACTLSWAIYEL 342 Neurospora cr...
EEQ39970            239 .[13].KKFSEAIKRVHAFTSQFVDRV.[15].YTFLYELAKVT.[1].DPIVMRDQILNVMLAGRSTTASLLCSVLLEL 330 Clavispora lu...
EAL86290            230 .[13].KDFYAACETVKAYVEKVVRKE.[23].QSLLSRILDNT.[1].DVHAVRDAVVTILIAGTDSVASMLSTTFYLL 329 Aspergillus f...
WGS:AACS:CC1G_05498 286 .[15].DTVKPNRDIVDQIIEPIVDKA.[ 5].TLGDVEKVEKG.[1].EETLLKHLLLNLLVAGRDTTACTLTYSVYML 369 Coprinopsis c...

Feature 1                                                  #            # #                           # 
P30611              319 SRKSHHLGKLREEIDANFG.[15].KYVQAILNETLRMYPG.[1].PRNMKTAKCTTTLPKG.[9].LVKKGQSVGFISI 407 Candida tropi...
AAL67906            327 SQYPEVLRRLREEILEKVG.[13].KYLRAFINETLRLYPA.[1].PWNVRYPVKDTTIPGP.[6].FIPANTPVSYSVH 410 Phanerochaete...
EAL85431            359 SGHPDVVQRLREEILAQVG.[13].RYLQAIHKETLRLYPA.[1].PFNMRVALSDTTLPSG.[9].HVKKDTIVAYSPL 445 Aspergillus f...
EAA59226            349 ARNPEVTAKLREEIASRLG.[16].KYLNAVLNESMRLYPV.[1].PFNVRFSLKDTTLPRG.[9].AVRAGTRVVYSTM 438 Aspergillus n...
EAA60936            641 SHYPEAYSKLRAEILDKVG.[13].PYLRHTINEVLRLYPA.[1].PYNIRFALTDTTLPIG.[9].TILKGDAVAYSTY 727 Aspergillus n...
EAL22122            358 VLHPDIAVRLKDEVFTIAN.[13].RYCRAFINEVLRLFPP.[1].PLNIRRTLRPSLLPTP.[4].YMPANTSIILATI 439 Cryptococcus ...
EAA28794            343 ARHPEAVAKLRAEILSVVG.[13].KYLQNVMNETLRLYPV.[1].PFNVRMALKDTTLPRG.[9].VILKDTPVGYSPL 429 Neurospora cr...
EEQ39970            331 SRNPEVYEKLKNEVYEQFG.[17].TYLRWVLNEGLRMYPP.[1].PSNLRQAVRDTTLPKG.[9].LVRKGQYVALHIY 421 Clavispora lu...
EAL86290            330 ARHERVYAKLRQEILDTIG.[12].TYLRYVFNEAMRVYPP.[1].PFNARTANRDTYLPAG.[9].LIRKGQRVIFASW 415 Aspergillus f...
WGS:AACS:CC1G_05498 370 AENPHVAERLRSEILNKVG.[13].RYLRAFINEVLRLYPP.[1].PFNTRRAINDTVFTTK.[6].FIPGDTQVGYSVW 453 Coprinopsis c...

Feature 1                                                 ###   #####  ##                              
P30611              408 ATHLD.[ 5].GSDAHVFRPDRW.[ 8].GCKYLPFNAGPRTCLGQQYTLIEASYLLVRLAQTYE.[ 8].VYPPRKKA 489 Candida tropic...
AAL67906            411 CMHRR.[ 4].GPDAEAFDPDRF.[12].PFIFLPFNAGPRICLGQQFAYNEMSFFVIRLLQHFD.[23].GRKGVERF 510 Phanerochaete ...
EAL85431            446 YMHRS.[12].FSDPREYHPHRW.[21].PWTYIPFNGGPRICLGQQFALAEMGYTLVRIFQKYK.[ 2].ERRMRAED 541 Aspergillus fu...
EAA59226            439 IMQRS.[11].YFDPAQWNPERW.[ 7].PWQFIPFNGGPRICIGQQFAMIEMGYTVVRILQAFE.[12].VEDPRLRF 529 Aspergillus ni...
EAA60936            728 AMQRR.[10].FADPAIFSPERW.[ 6].PWHYVPFNGGPRICIGQNFALAEMGYTIVRILQRYE.[ 4].VGDWERQF 808 Aspergillus ni...
EAL22122            440 LMQRD.[ 4].GEDAQVFNPDRW.[ 9].KEGFMSWNLGPRMCLGQSFALAITHTFLVYFFRHIA.[17].AQPPETVL 530 Cryptococcus n...
EAA28794            430 AMQRR.[10].FPDVEMFSPDRW.[ 6].PWQYIPFNGGPRICIGQQFALTEMGYVLTRLFQRYD.[10].GGKPRMKT 516 Neurospora cra...
EEQ39970            422 SMHRS.[ 4].GKDALSFRPERW.[ 6].GWAFMPFGSGPRICLGQQFALTEASYILVRMVQDFP.[ 7].TYPPRTYS 499 Clavispora lus...
EAL86290            416 GSHRS.[ 4].GADALEFRPERW.[ 6].SLGYIPFSAGPRVCLGQQYALLEASYATIRIIQTFE.[ 6].VRPWTEKI 492 Aspergillus fu...
WGS:AACS:CC1G_05498 454 DMHRR.[ 4].GPDAYEFDPDRF.[12].PFIFTPFNAGPRICLGQQFAYHEASFFLIRLLQQFS.[23].GRKGMEKI 553 Coprinopsis ci...

Feature 1                               
P30611              490 .[1].INMCAADGVDV 501 Candida tropicalis
AAL67906            511 .[5].LTLYAKGGLWV 526 Phanerochaete chrysosporium
EAL85431            542 .[7].IVLTPAQEVNV 559 Aspergillus fumigatus Af293
EAA59226            530 .[1].VTLTPASELNC 541 Aspergillus nidulans FGSC A4
EAA60936            809 .[4].IVGTPGMGVKL 823 Aspergillus nidulans FGSC A4
EAL22122            531 .[2].EWMTPEGGDGR 543 Cryptococcus neoformans var. neoformans B-3501A
EAA28794            517 .[1].IVLMPGDGVKV 528 Neurospora crassa OR74A
EEQ39970            500 .[1].STMHYIDGIRI 511 Clavispora lusitaniae ATCC 42720
EAL86290            493 .[1].LNLSNKNGVLV 504 Aspergillus fumigatus Af293
WGS:AACS:CC1G_05498 554 .[5].LTLIVKGGLWV 569 Coprinopsis cinerea okayama7#130

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