3K51,3MHD,3MI8


Conserved Protein Domain Family
TNFRSF6B
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cd10575: TNFRSF6B 
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Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), also known as decoy receptor 3 (DcR3)
The subfamily TNFRSF6B is also known as decoy receptor 3 (DcR3), M68, or TR6. This protein is a soluble receptor without death domain and cytoplasmic domain, and secreted by cells. It acts as a decoy receptor that competes with death receptors for ligand binding. It is a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases, and cancer. Over-expression of this gene has been noted in several cancers, including pancreatic carcinoma, and gastrointestinal tract tumors. It can neutralize the biological effects of three tumor necrosis factor superfamily (TNFSF) members: TNFSF6 (Fas ligand/FasL/CD95L) and TNFSF14 (LIGHT) which are both involved in apoptosis and inflammation, and TNFSF15 (TNF-like molecule 1A/TL1A), which is a T cell co-stimulator and involved in gut inflammation. DcR3 is a novel inflammatory marker; higher DcR3 levels strongly correlate with inflammation and independently predict cardiovascular and all-cause mortality in chronic kidney disease (CKD) patients on hemodialysis. Increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis is also associated with the elevated DcR3 expression. In cartilaginous fish, mRNA expression of DcR3 in the thymus and leydig, which are the representative lymphoid tissues of elasmobranchs, suggests that DcR3 may act as a modulator in the immune system. Interestingly, in banded dogfish (Triakis scyllia), DcR3 mRNA is strongly expressed in the gill, compared with human expression in the normal lung; both are respiratory organs, suggesting potential relevance of DcR3 to respiratory function.
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Statistics
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PSSM-Id: 276901
Aligned: 17 rows
Threshold Bit Score: 249.631
Created: 13-Jun-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptideCRD1CRD2CRD3
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide ligand binding site [polypeptide binding site]
Evidence:
  • Structure:3K51: Human tumor necrosis factor receptor TNFRSF6B (also known as DcR3) binds TNFSF15 ligand (TL1A); contacts at 4.0A
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Sequence Alignment
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Feature 1                                                               #### ###   #             
3K51_B         7 PTYPWRD.[2].TGERLVCAQCPPGTFVQRPCR.[1].DSPTTCGPCPP.[1].HYTQFWNYLERCRYCNVLCGEREEEA 75  human
XP_006008800  38 PTYQQKD.[2].SGETLTCNQCPKGTYVVKHCT.[1].DQQTVCGPCPS.[1].HYTAFWNYLDKCRYCNVFCGENQVET 106 coelacanth
BAF62126      25 PTYKRRD.[2].TGQMVTCEQCPPGTFVKEHCT.[1].IQPTMCERCPD.[1].HYTQYWNYLQKCRYCNVFCVDYQYEK 93  banded houndshark
AAI59341      38 LTYQWKD.[2].TGELLICNKCQPGTSVAKHCT.[1].TSPTQCQPCPD.[1].HYTQYWNYLDKCRYCNVFCEDRERVK 106 African clawed frog
XP_006639513  24 PTYQWKD.[2].TGEAVTCEKCPPGTHMKRHCG.[1].DRRTECAPCPG.[1].HYTEFWNYIDECRYCNVFCTENEFEK 92  spotted gar
BAG12082      25 STYQWTD.[2].TGFPVTCDKCPPGTHVVKHCT.[1].DRKTVCGLCPE.[1].HYTAFWNYVERCLYCNVFCMEDQFEK 93  whitespotted conger
YP_003358263  19 KVPTWTD     PVTGLTCDRCPAGTHVVKQCT.[1].TTPTECGACPA.[1].HYTEFWNYLNRCLYCGVRCTEQQVEK 85  Anguillid herpesvirus 1
KFO85438      17 PTYQWKD.[2].TREKLTCQQCPPGTFVAQHCT.[1].DRQTVCAPCPD.[1].HYTQYWNYLEKCRYCNVICGEKQVEV 85  Buceros rhinoceros s...
XP_008496003  21 PTYQWKD.[2].TREKLTCLQCPPGTFVAQHCS.[1].ERQTVCQPCPD.[1].HYTQYWNYLEKCRYCNVICEEQQVEV 89  Anna's hummingbird
CDQ96070      29 PTYIWRD.[2].TGVSFTCDKCPPGTHLRMRCT.[1].DSKTECEPCPK.[1].HYTEIWNYIERCQYCNIFCTDDQFVS 97  rainbow trout


Feature 1                                                                                        
3K51_B        76 RACHATHNRACRCRTGFFA.[3].FCLEHASCPPG.[1].GVIAPGT.[3].NTQCQPCPPGTFS.[8].CQPHRNCTAL 150 human
XP_006008800 107 RQCSATHNRVCECQPGYYL.[3].FCMKHSTCPPG.[1].GVSKPGD.[3].DTKCDPCLPGHFA.[6].CRRHTDCASS 179 coelacanth
BAF62126      94 HQCNSTHNRVCECQPGYYL.[3].FCLKQSSCPYG.[1].GVIKMGT.[3].DTNCEPCSHGYFS.[8].CFIHTNCTKE 168 banded houndshark
AAI59341     107 HECNATHNRVCECQPGYHR.[3].FCVQHKACDPG.[1].RVSQEGT.[3].NTECAPCPAGTFA.[8].CRPHTNCSSL 181 African clawed frog
XP_006639513  93 RKCSPTHNRLCECRAGFYR.[3].FCIRHSVCPAG.[1].GVVANGT.[3].DVQCQTCPIGSYS.[8].CRPHRWCPPG 167 spotted gar
BAG12082      94 LPCNTTHNRVCECKSGHYF.[3].FCTKHSACPPG.[1].GASMTGT.[3].DVKCVKCEEGYFS.[8].CQKQHQCKDG 168 whitespotted conger
YP_003358263  86 STCSATHNRVCECKPGYHI.[4].FCLRHSTCPPG.[1].GLLVAGT.[3].NTRCGPCQAGYFS.[7].CKPHTPCKDT 160 Anguillid herpesvirus 1
KFO85438      86 QQCNSTHNRVCQCQEGYYS.[3].FCIKHSECPPG.[1].GVKELGT.[3].NTQCHPCPPGFFS.[8].CQSHQDCKQQ 160 Buceros rhinoceros s...
XP_008496003  90 QRCNSTHNRVCQCREGYYS.[3].FCIRHSECPPG.[1].GVEKLGS.[3].DTQCQPCPHGFFS.[8].CQPHQDCQQQ 164 Anna's hummingbird
CDQ96070      98 VQCTQFHNRKCECKDGFYM.[3].SCSRHSRCLPG.[1].GVLSNGT.[3].DVTCEPCRGGFFS.[8].CQKFTVCTPD 172 rainbow trout


Feature 1                                
3K51_B       151 G.[2].LNVPG.[3].HDTLCTST 169 human
XP_006008800 180 G.[2].VNVPG.[3].HDTLCTTC 198 coelacanth
BAF62126     169 G.[2].VNVPG.[3].HDTLCTSC 187 banded houndshark
AAI59341     182 G.[2].VNVPG.[3].HDTLCTSC 200 African clawed frog
XP_006639513 168 Q     IAIPG.[3].HDTFCSSC 184 spotted gar
BAG12082     169 E     RTIPS.[3].RDTFCTLC 185 whitespotted conger
YP_003358263 161 E     RSVPG.[3].QDTFCTSC 177 Anguillid herpesvirus 1
KFO85438     161 G.[2].TNVPG.[3].HDTLCTSC 179 Buceros rhinoceros silvestris
XP_008496003 165 G.[2].TNVPG.[3].HDTLCTSC 183 Anna's hummingbird
CDQ96070     173 R     TTIPG.[3].HDVYCSAC 189 rainbow trout

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