3BS5,1WWV


Conserved Protein Domain Family
SAM_CNK1,2,3-suppressor
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cd09511: SAM_CNK1,2,3-suppressor 
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SAM domain of CNK1,2,3-suppressor subfamily
SAM (sterile alpha motif) domain of CNK (connector enhancer of kinase suppressor of ras (Ksr)) subfamily is a protein-protein interaction domain. CNK proteins are multidomain scaffold proteins containing a few protein-protein interaction domains and are required for connecting Rho and Ras signaling pathways. In Drosophila, the SAM domain of CNK is known to interact with the SAM domain of the aveugle protein, forming a heterodimer. Mutation of the SAM domain in human CNK1 abolishes the ability to cooperate with the Ras effector, supporting the idea that this interaction is necessary for proper Ras signal transduction.
Links
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Statistics
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PSSM-Id: 188910
Aligned: 14 rows
Threshold Bit Score: 105.451
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface EH [polypeptide binding site]
Evidence:
  • Structure:3BS5, Human/Drosophila, SAM_CNK2/SAM_HYP dimer, contacts at 4A.
    - View structure with Cn3D
  • Comment:The end-helix (EH) surface of the SAM domain of human CNK2 protein interacts with the mid-loop (ML) surface of the SAM domain of Drosophila HYP (or aveugle) protein.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                         #                           #   #    ######## ##  #     
3BS5_B          4 VSKWSPSQVVDWXKGLDDCLQ.[2].IKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCAL 72   human
1WWV_A         11 VETWTPGKVATWLRGLDDSLQ     DYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELILGGVEQLQAL 77   human
Q6P9H4          4 VTKWSPKQVVDWTRGLDDCLQ.[2].VHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCAL 72   human
XP_419685     102 VTKWSPKQVVDWTKGLDDCLQ.[2].VHKFEREKINGEQLLQISHQDLEDMGITRIGHQELVLEAVDLLCAL 170  chicken
XP_002612583    4 VGSWTPKQVGLWLKGLDDAVQ.[2].IQSFILAGVTGEQLLNLSHRDMDRLNITKLGHQELILEAVDLLCAL 72   Florida lancelet
XP_002424634    6 VAEWRPEQVTEWLKGLDNCIV.[2].IHWFSNNEVNGQQLLNLTPDDLTHLGVFKLGHQELILEAVQHLRNF 74   human body louse
NP_725671       6 IAEWTPDQVTDWIKGLDESMK.[2].LYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRNF 74   fruit fly
XP_001949129    6 VADWKSDQVADWLKGLDSVII.[2].IKYFIDTDVNGQKLLDMQPNDLDKIGVQKIGHQELILEAVDLLRNF 74   pea aphid
XP_970755       6 VRDWSVDQVTDWLKGLDSIIL.[2].TTSFLNNGVTGHQLLNLRADDLDNLGVKSLGHQELILESVEHLRHF 74   red flour beetle
NP_991222       4 VASWSTERVTEWLKGLDAPLQ     QYPFSEWQLSGSDLLQLSSSRLENIGVHKIGHQELILEAVEKLCAL 70   zebrafish

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