Conserved Protein Domain Family
C2_KIAA0528-like

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cd08688: C2_KIAA0528-like 
C2 domain found in the Human KIAA0528 cDNA clone
The members of this CD are named after the Human KIAA0528 cDNA clone. All members here contain a single C2 repeat. No other information on this protein is currently known. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176070
Aligned: 18 rows
Threshold Bit Score: 164.788
Created: 24-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

NP_055617       5 LKVKIVAGRHLPVMDR.[4].TDAFVEVKF.[3].TFKTDVYL.[3].NPQW.[1].SEWFKFE.[ 9].PLQITVLDHD 78   human
XP_001639653    5 VKVRIVAARDLPVMDR.[4].ADAFVEVRL.[3].MNKTEVCK.[3].NPQW.[1].SEWFRFE.[ 9].PLQIRIMDYD 78   starlet sea anemone
XP_002108582   48 INVKIVAGRNFPVMDR.[4].ADAFVEVKF.[3].TYKTDVCK.[3].NPSW.[1].CDWFRFE.[ 9].CLEIKVLDHD 121  Trichoplax adhaerens
NP_732985       5 VGVKIKAARNLPVMDK.[4].TDAFVEIKL.[3].THKTDVFR.[3].NPTW.[1].TDWFRFE.[ 9].PLQIRLMDYD 78   fruit fly
XP_002573547    5 VKVRVISARNLPVMDR.[4].TDAFVELCI.[3].TYKTEVVR.[3].NPSW.[1].SEWFCFE.[ 9].ALLLKVMDHD 78   Schistosoma mansoni
XP_646056       5 LKVRIIEGRDLPIMDR.[4].ADAFVEIRC.[4].PQKTDIQK.[3].NPVW     NQDFRFD.[10].PLDIRVWDYD 79   Dictyostelium disc...
XP_001891658   14 LSVRVISARGLPVMDK.[4].TDAFVEVHF.[3].VYKTDVCS.[3].SPVW.[1].SDVFVFE.[ 9].PVQFRVMDHD 87   agent of lymphatic...
EEY70467        5 IKIRLVEARDMPVVDR.[4].ADAYVSITF.[3].EAKSSVSK.[3].NPKW     DEEFRFD.[10].PIEFKLMDHD 78   Phytophthora infes...
NP_508464      14 LEICVISAKALPVMNK.[4].TDAFVEVRF.[3].IDKTDVVT.[2].NPVW.[1].SEQFVFD.[ 9].WLQLRVMDHD 86   nematode
XP_828493       4 LTVTVHEARDLPVMDR.[4].ADTYVVVKL.[3].EYTTDISR.[3].HPVW     NRVFRFD.[10].PLEVRVYDHD 77   Trypanosoma brucei...

NP_055617      79 .[4].NDAIGKVYI.[14].SGWFPIYDT 114  human
XP_001639653   79 .[4].HDAIGKVNI.[14].NGWFPIYDT 114  starlet sea anemone
XP_002108582  122 .[4].HDAIGMVYV.[14].SGWFPVYDT 157  Trichoplax adhaerens
NP_732985      79 .[4].NDAIGKVNI.[21].SGWIPVFDT 121  fruit fly
XP_002573547   79 .[4].HDTIGRVYF.[14].NGWFPIYDT 114  Schistosoma mansoni
XP_646056      80 .[4].NDVIGSVLI.[15].NGWFPIYDT 116  Dictyostelium discoideum AX4
XP_001891658   88 .[4].NDAIGRVFY.[21].TNWLPIYDS 130  agent of lymphatic filariasis
EEY70467       79 .[4].DATVGIVYV.[13].QGWFPVYDT 113  Phytophthora infestans T30-4
NP_508464      87 .[4].NDAIGRVNI.[19].TFSFKVYDT 127  nematode
XP_828493      78 .[4].DDIVGHTFV.[13].SGWFPLFDT 112  Trypanosoma brucei TREU927
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