3HZ6,3KZB


Conserved Protein Domain Family
ASKHA_NBD_FGGY_CvXK-like
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cd07805: ASKHA_NBD_FGGY_CvXK-like 
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nucleotide-binding domain (NBD) of Chromobacterium violaceum xylulose kinase (CvXK) and similar proteins
The subfamily contains a group of uncharacterized proteins with similarity to Chromobacterium violaceum xylulose kinase (CvXK). Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.
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Statistics
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PSSM-Id: 466807
Aligned: 141 rows
Threshold Bit Score: 374.549
Created: 29-Jun-2009
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:active site includes: Mg.ATP, phosphate ion, and D-xylulose binding sites, and catalytic residues conserved in the actin-like superfamily
  • Structure:3HZ6; Chromobacterium violaceum xylulokinase binds ADP, phosphate ion, and D-xylulose, contacts at 4A
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Sequence Alignment
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Feature 1             # #### #                                                             ###   
3HZ6_A         6 YIATFDIGTTEVKAALAD.[2].GGLHFQRSIAL.[9].VEQDAGDWYDAVQRIASSWWQ.[ 7].VSAIVLSGQXQNFL 87  Chromobacterium viol...
WP_048314448   4 KVISYDLGTGGIKASLFN.[2].GEALHSVFIPY.[9].QEQAPEDWWQAIIRSTRHLLD.[ 8].ITALAISGHSLGVV 86  Parabacteroides gold...
SCI88769       6 KIIAYDLGTGGIKSSLFD.[2].GTSLVHTFQAY.[9].HEQKPEDWWNGIVETTRLLMK.[ 8].VKGLAISGHSLGVV 88  uncultured Roseburia...
OHB57421       4 YIIAYDLGTGGNKASLYN.[2].GKCLAASFVAY.[9].HEQRPDDWWQAIVESTRHLLE.[ 8].ITCCGISGHSLGVV 86  Planctomycetes bacte...
OJX98626       4 LVLACDLGTGGLKGAVFA.[2].GERLAETFEHY.[9].HEQKPAEWWDALVRAMNTLLK.[11].IKAISLSGHSLGCI 89  Rhizobiales bacteriu...
PKN98567      22 YVVSYDLGTGGLKAGLYQ.[2].GVSVGFEFVSY.[9].HEQRPQDWWQAVCLATKTLMQ.[ 8].VAAVAASGHSLVAA 104 Chloroflexi bacteriu...
RAZ32603      10 LVLAYDLGTGGCKASLWT.[2].ATMLAETVVPY.[9].NEQRPDDWWDAVAASTRHLLE.[ 8].IAGVALSGQSLGAV 92  Microbacterium sp. SMR1
TFG62345       5 HILAFDLGTGGNKAVLYD.[2].GVLLGSAFSPY.[9].AEQRPLDWWESLITTTRELLK.[ 8].IGCLCISGHGIGVV 87  Spirochaetales bacte...
WP_136079402   4 YIIAYDFGTGGTKASLYD.[2].GECLASGFESY.[9].HEQRPADWWQSVVESTRKLFE.[ 8].VAAIGVSGHSLGLV 86  Kiritimatiellales ba...
WP_147211699   4 RIIAYDLGTGGNKASLYD.[2].GNCLESVFVEY.[9].HEQKPEEWWNAIVKSTQVLIE.[ 8].IHCCGISGHSLGVV 86  Oceanobacillus sojae


Feature 1                      #                                                                 
3HZ6_A        88 PLD.[5].LHRAVLYSDKR.[1].LKEAEEINA.[19].ILPKLVFWRASFP.[6].RHVVLGAKDYVVLRLTG.[1].H 173 Chromobacterium viol...
WP_048314448  87 PIG.[6].QAATPIWSDRR.[1].SSEAEAFFN.[20].SVFKIMWYKKHFP.[5].TDKIIGTKDYCNYRFTG.[1].L 173 Parabacteroides gold...
SCI88769      89 PVA.[6].RSYTPIWSDKR.[1].GRQAAEFFK.[20].SVFKIMWYRDAEP.[5].TYKILGSKDYCNFVMTG.[1].A 175 uncultured Roseburia...
OHB57421      87 PID.[6].RDTVPIWSDSR.[1].EPQQLEPFF.[21].SVFKILWLRDNEP.[5].INKVIGTKDYINFKLTG.[1].I 174 Planctomycetes bacte...
OJX98626      90 PVD.[6].QDAVPLWSDGR.[1].QDMARCFFR.[20].PLFKIMWLREHRP.[5].THRILGTKDYLNHLMTG.[1].I 176 Rhizobiales bacteriu...
PKN98567     105 PIN.[6].LESVPIWSDRR.[1].KVQATEFFK.[20].SVFKLMWLKKHYP.[5].TSAVLGSKDFLNFMLTG.[1].I 191 Chloroflexi bacteriu...
RAZ32603      93 QVD.[6].APTTPIWSDTR.[1].RPDAVFGDI.[18].PLTKAAAFRAEDA.[5].TRHLVGSKDWINLRLTG.[1].L 177 Microbacterium sp. SMR1
TFG62345      88 PVA.[6].REKTLLWSDSR.[1].VPQTKEYFR.[20].AIFKIMWHRDHEP.[5].TYKFIGTKDFLNMKMTG.[1].I 174 Spirochaetales bacte...
WP_136079402  87 PLD.[6].RDQVPIWSDSR.[1].NSQVPEFFG.[20].TVFKIMWLRDNEP.[5].IHTVIGTKDYINFKMTG.[1].V 173 Kiritimatiellales ba...
WP_147211699  87 PLD.[6].RESTPIWSDYR.[1].EKEVADFFS.[20].AAFKILWYKNNEP.[5].IDKVVGTKDYINFKLTG.[1].V 173 Oceanobacillus sojae


Feature 1                  #                                                                  ## 
3HZ6_A       174 ATDRT.[3].TTGLYRPK.[1].DAWHVELLADYG.[5].XPRLLEPGEQVGGVSALAARQTG.[3].GTPVLCGLGDAG 245 Chromobacterium viol...
WP_048314448 174 CTDYS.[3].GSGVFDLK.[1].WNYKEEYVQASG.[5].FPEILDSDAIVGTITPEASLETG.[3].HVRVICGGVDNS 245 Parabacteroides gold...
SCI88769     176 YTDYS.[3].GSGVYSLK.[1].RAYVDEYIQTAG.[5].LPEIIPSHGVVGNLLEGPARELG.[3].ETKVICGGVDNS 247 uncultured Roseburia...
OHB57421     175 ATDYS.[3].GCGVYDLN.[1].WKYNDELIAAAG.[5].LPRIVPSTEVLGHLTPDAAKEIG.[3].TLQVVAGGVDNS 246 Planctomycetes bacte...
OJX98626     177 ATDPS.[3].GSGCYDLL.[1].GDYAADVLSAAG.[5].LPPVTPSASVVGPLLPEPAAALG.[3].GTAVVAGGVDNS 248 Rhizobiales bacteriu...
PKN98567     192 ATDFS.[3].GSGVFDLL.[1].WGYKDAYIEKAG.[5].FIEPIESHALVGRVTAKAAEACG.[3].GIGVFCGGVDNS 263 Chloroflexi bacteriu...
RAZ32603     178 ATDHS.[3].GSGAYDLA.[1].GDYDDELLAAAE.[5].FPRIVPSSARVGSLTRGAAEALG.[3].GIPVFAGAVDNA 249 Microbacterium sp. SMR1
TFG62345     175 VSDFS.[3].FSGVNDLM.[1].WEYSEELLKETG.[5].LPELIPSTSVVGELLQNPADEMG.[3].GIPVICGGYDGS 246 Spirochaetales bacte...
WP_136079402 174 ATDYS.[3].GSGVYDLK.[1].WRYSARLIAASG.[5].FPKIVPSTEVLGTLTAAAAAELG.[3].SVKVVAGGVDNS 245 Kiritimatiellales ba...
WP_147211699 174 RTDYS.[3].GYGVYDLV.[1].WQYSDELLEATG.[5].FPEIIASDAVVGTILPEVAKEIG.[3].NTQVVCGGVDNS 245 Oceanobacillus sojae


Feature 1                            ##                 #              # #        ##  #      
3HZ6_A       246 AATLGVG.[3].DEDAYLHLGTTGWLARLTQ.[10].TIFRLAG.[3].GKTLQVAPVL.[1].AGNILQWALTLV 317 Chromobacterium violaceum
WP_048314448 246 CMALGSK.[3].PSRIYTSLGSSAWIALVSE.[ 8].KPYVFAH.[3].GMYASATCIF.[1].AGSSLQWVRNTI 315 Parabacteroides goldsteinii
SCI88769     248 CMALGAK.[3].HGRTYTSLGSSSWIAVIAK.[ 8].LPFVFEH.[3].GLYTSATSIF.[1].AGNSFRWVRDCI 317 uncultured Roseburia sp.
OHB57421     247 CMALGAR.[3].EGRSYNSLGSSSWIAVCSS.[ 8].RPYVFAH.[3].GMFASATAIF.[1].AGSSFRWIKDQL 316 Planctomycetes bacterium...
OJX98626     249 CMALGAQ.[3].DGDLFSSMGSSSWLTISAP.[ 8].RSYAFAH.[3].GQFISATSIF.[1].SGTTMDWARNRV 318 Rhizobiales bacterium 63-22
PKN98567     264 CMALGTT.[3].KDRVYTSLGSSAWIAVSAE.[ 8].LPFVFAH.[3].GYYTTGVSIF.[1].AGSAYRWAKETL 333 Chloroflexi bacterium HG...
RAZ32603     250 AMALGSR.[3].EGRIYAALGSSSWITVTSA.[ 8].RPYVFAH.[3].GMFVSALSTF.[1].SGTSLEWLRATL 319 Microbacterium sp. SMR1
TFG62345     247 CTALGAG.[3].ENRVYNYVGSSSWISVASD.[ 8].KPYCYYH.[3].GMFNSTVSIY.[1].AGSSYQWVRNVL 316 Spirochaetales bacterium
WP_136079402 246 CMALGAM.[3].EGACYNAMGSSSWIAVSSA.[ 8].RPYVFTH.[3].GMFASATAIF.[1].AGSSLRWLKETL 315 Kiritimatiellales bacterium
WP_147211699 246 CMALGAK.[3].EGRIYNSQGSSSWIAISSQ.[ 8].RPYIFTH.[3].GYYANALCLA.[1].GGTSFRWIRDQF 315 Oceanobacillus sojae


Feature 1                 #                                                                      
3HZ6_A       318 .[ 8].AEYFHXAAAEV.[7].GLLFVPYL.[1].AERCPVELPAPRGALLG.[6].RAQILLAVLEGAALSLRWCAELL 398 Chromobacterium viol...
WP_048314448 316 .[15].YIAMNKLAETS.[5].GLLFNPSL.[1].GGSSIEPSPDMTGAFTG.[6].RADLIRATMEGIALNLRIALDLF 401 Parabacteroides gold...
SCI88769     318 .[16].YDEMNKMVTES.[5].KLIFNPSF.[1].GGAMIEESPDICGGYIG.[6].RNDMVRSAMEGITYNLYYAMLVL 404 uncultured Roseburia...
OHB57421     317 .[15].YDLMSDLARQS.[5].GLLFNPSL.[1].GGSLLDADPAIRGAFIG.[6].RNDLIRAAMEGISIGLRVALDEL 402 Planctomycetes bacte...
OJX98626     319 .[ 6].LAELEACAAAS.[5].GLLMAPTL.[1].GGTSLEGGAEVRGAYLG.[6].RSDLVRAAYEGVSYGLRVALDAL 395 Rhizobiales bacteriu...
PKN98567     334 .[ 8].YEKMNALVAES.[5].GVMFNPSL.[1].GGSSQEPSEELAGAFFG.[6].RSDLLRAILEGVALSLGTCCLAV 412 Chloroflexi bacteriu...
RAZ32603     320 .[ 6].ADFIGLAADSA.[4].GVSFVPTL.[1].GGTPLEGGSGARGGFTG.[6].PADLVRACLEGIAFSLDRSLALM 395 Microbacterium sp. SMR1
TFG62345     317 .[15].YEIMNEEAAQA.[5].NVFFNPSL.[1].GGATIYPSPNLRGAFAG.[6].KADLMRAVMEGVAYDLRLVLDCF 402 Spirochaetales bacte...
WP_136079402 316 .[ 5].YDALIAEAQTA.[5].GVVFVPHL.[1].GGSSLDESPAVRGGFLN.[6].RADLVRAVLEGICFGLKRALDAL 391 Kiritimatiellales ba...
WP_147211699 316 .[15].YDLITEKAAQS.[5].GLIFNPSL.[1].GGLPIDKSLNIQGGYIG.[6].QADLYRAAMEGITLGQRICLDKI 401 Oceanobacillus sojae


Feature 1                   ###  #                                                               
3HZ6_A       399 .[5].GLLKVVGGGARSEAWLRXIADNL.[1].VSLLVKP.[4].HPLRGLAALAAVEL.[15].REPASNILHP.[4]. 481 Chromobacterium viol...
WP_048314448 402 .[7].SEMLFVGGGTKSDFWMQLFADIY.[1].LEIQKTN.[4].AASLGAAALALKGT.[11].LHQEQQRFRP.[4]. 482 Parabacteroides gold...
SCI88769     405 .[7].HEMLLVGGGSKSRVWRQMFADVF.[2].RMIKTVV.[3].AASLGAAALAAYGL.[11].IHVVESIQEP.[7]. 488 uncultured Roseburia...
OHB57421     403 .[7].DEMIAVGGASKSEVWRQIFADVY.[1].MKIVKTS.[4].TAALGAAALAAVGT.[11].VNKIESVVKP.[4]. 483 Planctomycetes bacte...
OJX98626     396 .[7].DSMVAVGGGAKSSFWRQILADIL.[1].IDVVKTS.[4].AATLGAAAVAFRAM.[11].IHKVESVSRP.[4]. 476 Rhizobiales bacteriu...
PKN98567     413 .[8].EPMIMCGGGAKSELWMQIFADVY.[1].RKVVIAN.[4].AASLGAAAIALRGA.[11].LFQIQKTYLP.[4]. 494 Chloroflexi bacteriu...
RAZ32603     396 .[7].EPLLITGGGSRSPLWNGIYADIL.[1].SPLQRST.[4].AATLGAATIALVGL.[11].AHAGLDEIAP.[2]. 474 Microbacterium sp. SMR1
TFG62345     403 .[7].DEVRLVGGGSRSGLWRQIFADIY.[1].TKIILTN.[4].AAALGAATIGAIGA.[11].IAKTVHVSKP.[4]. 483 Spirochaetales bacte...
WP_136079402 392 .[7].EEMLAVGGGSRNDDWMQLYADIY.[1].KTMVRTN.[4].AAALGAAALAAVGS.[11].VHEVTDRKAP.[2]. 470 Kiritimatiellales ba...
WP_147211699 402 .[7].DEMLVVGGGARSELWRQISADGY.[1].VTILKTN.[4].AAALGAAALAAVGT.[11].IHEIELVIKP.[4]. 482 Oceanobacillus sojae


Feature 1                    
3HZ6_A       482 EGRRRRKFERFK 493 Chromobacterium violaceum
WP_048314448 483 QATYRKVLDNFK 494 Parabacteroides goldsteinii
SCI88769     489 YRTYYELHRKFA 500 uncultured Roseburia sp.
OHB57421     484 NNTYNKIIPIFQ 495 Planctomycetes bacterium GWF2_50_10
OJX98626     477 RDLYAAGLGAYR 488 Rhizobiales bacterium 63-22
PKN98567     495 HKSYTLLAKRFT 506 Chloroflexi bacterium HGW-Chloroflexi-4
RAZ32603     475 PESYAGARDRFD 486 Microbacterium sp. SMR1
TFG62345     484 ETAYEKRLPLFR 495 Spirochaetales bacterium
WP_136079402 471 TGEYNGCYARFL 482 Kiritimatiellales bacterium
WP_147211699 483 VAKYNQLLENFV 494 Oceanobacillus sojae

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