1JS6,1XEY,2JIS,2QMA


Conserved Protein Domain Family
DOPA_deC_like

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cd06450: DOPA_deC_like 
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DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Statistics
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PSSM-Id: 99743
View PSSM: cd06450
Aligned: 40 rows
Threshold Bit Score: 312.6
Threshold Setting Gi: 6320500
Created: 30-Jun-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1JS6_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                     
1JS6_A     76 FFAY.[ 8].AMLADML.[19].LETVMMDWLGKM.[15].GGVIQG.[1].ASEATLVALLAA.[24].VAYAS.[2]. 190 pig
CAA09590  144 RASG.[ 8].LTELLVK.[21].IEAEIVRIACSL.[ 7].CGCVTS.[1].GTESILMACKAY.[12].EIVAP.[2]. 240 human
NP_616872  67 NLAS.[ 9].ADKLVME.[18].IHHNMVNMLGRL.[ 8].VGTSTA.[1].SSEAIMLGLLAH.[14].NIIFG.[2]. 164 Methanosarcina acetivor...
NP_652032 132 RVSG.[ 8].LVELVTE.[21].MEAEVVRMACNL.[ 7].CGTMTT.[1].GTESIVMAMKAY.[13].NIVVP.[2]. 229 fruit fly
NP_499913 138 RVSG.[ 9].HINLLGK.[21].MEAELIRMVLNL.[ 7].SGSVTS.[1].GTESIIMACFSY.[12].VILAC.[2]. 235 Caenorhabditis elegans
CAB91763  146 YVSG.[ 8].LLKLQTE.[21].MEAEVVAMVLSL.[ 7].AGVSTS.[1].GTESILMAILSA.[13].EMIIP.[2]. 243 Neurospora crassa
NP_010580 168 KVSG.[ 8].LIHLQTI.[21].MESEVVSMVLRM.[ 8].CGTTTS.[1].GTESLLLACLSA.[13].EIIAP.[2]. 266 baker's yeast
AAP37027  116 KVSG.[ 8].HTKLLNE.[21].FETESISMVSNM.[ 7].VGSLTS.[1].GTESIFMAVKAY.[11].EIVVP.[2]. 211 Dictyostelium discoideum
NP_188403  58 NLAS.[ 9].CDKLIMD.[17].LQNRCVNMIANL.[11].IGCGTV.[1].SSEAIMLAGLAF.[18].NIVTG.[2]. 161 thale cress
NP_505372 130 RVSG.[10].EREMYEE.[21].MEAEVVRMCCNM.[ 7].CGTMST.[1].GSISILLACLAH.[13].MIVPS.[2]. 229 Caenorhabditis elegans

Feature 1                                                                                     
1JS6_A    191 AHSSVERAGL.[4].KLKAI.[11].ALQEAL.[9].PFFVVATLGTT.[7].LLEVGPICH.[3].IWLHVDAAYAGSA 278 pig
CAA09590  241 AHAAFNKAAS.[4].KIVRV.[11].AMRRAI.[3].TAMLVCSTPQF.[7].VPEVAKLAV.[3].IPLHVDACLGGFL 322 human
NP_616872 165 AHVCWDKFAR.[4].DTRKV.[12].AVAERI.[3].TICVGCVLGTT.[7].VKDINDLLL.[9].IPIHIDAASGGFI 253 Methanosarcina acetivor...
NP_652032 230 VHAAFDKGGQ.[4].HVRSV.[12].KFKRAI.[3].TILLVGSAPNF.[7].IEAIAALGV.[3].IPVHVDACLGSFV 312 fruit fly
NP_499913 236 AHAAFDKAAH.[4].RLRHV.[11].EMERLI.[3].VCMLVGSAPNF.[7].IPEIAKLGK.[3].IPVHVDACLGGFM 317 Caenorhabditis elegans
CAB91763  244 AHTAFRKAAE.[4].KLHLV.[12].RVARLI.[3].TIMLVGSAPNF.[7].ISALSKLAL.[3].IPLHVDCCLGSFL 326 Neurospora crassa
NP_010580 267 AHAGFDKAAY.[4].KLRHV.[12].KVKKFI.[3].TILLVGSAPNF.[7].IEGLGKIAQ.[3].LPLHVDSCLGSFI 349 baker's yeast
AAP37027  212 IHAAFDKACE.[4].RIVHI.[12].AMKKAI.[3].TILVAGSAVNF.[7].IDEIAKLAQ.[3].IGCHVDACLGGFI 294 Dictyostelium discoideum
NP_188403 162 VQVCWEKFAR.[4].ELKEV.[12].KAVEMV.[3].TICVAAILGST.[7].VKQLNDLLA.[9].TPIHVDAASGGFI 250 thale cress
NP_505372 230 HAAFFKAAEC.[3].KVRKI.[12].KMKAAI.[3].TCMLVGSAPNF.[7].IEAIGQLGL.[3].IPVHVDACLGGFL 311 Caenorhabditis elegans

Feature 1                    #                                                                
1JS6_A    279 F.[15].DSFNFNPHKWLLV.[2].DCSAMWVK.[41].SLKMWFVFR.[7].QAYIRKHVQLSHEFEA.[16].GLVCF 411 pig
CAA09590  323 I.[21].TSISADTHKYGYA.[2].GSSLVLYS.[33].SAAAWAALM.[7].VEATKQIIKTARFLKS.[16].SVIAL 453 human
NP_616872 254 L.[16].KSINVSGHKYGLT.[2].GLGWLIFR.[33].VAAQYYNFL.[7].TGIMKKILAVSQDLAE.[17].PIIAF 380 Methanosarcina acetivor...
NP_652032 313 V.[20].TSISADTHKYGFA.[2].GSSVILYS.[33].IAACWATMM.[7].LEATKRIVDTARYIER.[16].SVIAL 442 fruit fly
NP_499913 318 I.[20].TSISCDTHKYGCT.[2].GSSIVMYR.[33].TAVAWATLL.[7].VRRCAQIVKHTRMLAE.[16].SLVAF 447 Caenorhabditis elegans
CAB91763  327 V.[20].TSISCDTHKYGFA.[2].GNSTVLYR.[33].IAACWASLM.[7].LKSCTQIVGATKKLAE.[17].PLVSV 457 Neurospora crassa
NP_010580 350 V.[21].TSISCDTHKYGFA.[2].GSSVIMYR.[33].VVGCWATMV.[7].IESCQEIVGAAMKFKK.[17].SVISF 481 baker's yeast
AAP37027  295 L.[20].TSMSVDTHKFGYA.[2].GTSVVLFG.[33].VAACWASLV.[7].LEKAKGVMETTKKIIK.[16].MVVAF 424 Dictyostelium discoideum
NP_188403 251 A.[16].KSINVSGHKYGLV.[2].GVGWVVWR.[33].IIAQYYQFI.[7].KNIMENCMDNARRLRE.[17].PLVAF 377 thale cress
NP_505372 312 L.[17].SSISADSHKYGLA.[2].GSSVVLYR.[33].IALCWAAML.[7].KANARKIVDTTRKIRN.[16].CIVSW 438 Caenorhabditis elegans

Feature 1                                                              
1JS6_A    412 R.[7].NEALLERIN.[4].IHLVPC.[ 6].VLRFAIC.[6].GHVRLAWEHIRGL 470 pig
CAA09590  454 G.[5].IYRLSNLMT.[3].WNLNQL.[ 4].SIHFCIT.[6].RVAIQFLKDIRES 507 human
NP_616872 381 R.[8].LLQLSHKLR.[3].WIVPAY.[10].IMRIVVR.[5].DMASIIVEDLEKA 442 Methanosarcina acetivorans C2A
NP_652032 443 G.[5].IFRLSDSLC.[3].WNLNAL.[ 4].GIHLCVT.[6].GVADKFIADVRSC 496 fruit fly
NP_499913 448 S.[5].IYEVSDKMM.[3].WNLNTL.[ 4].AIHICLT.[6].EVVNAFAVDLEKI 501 Caenorhabditis elegans
CAB91763  458 L.[9].IYDIADGMS.[3].WHLNAL.[ 4].AIHVAVT.[4].KNWERLAQDLEGV 513 Neurospora crassa
NP_010580 482 S.[5].IHELSDRLS.[3].WHFNAL.[ 4].ALHMAFT.[4].HVVDEICDILRTT 533 baker's yeast
AAP37027  425 T.[3].IFYVNDYMS.[3].WHLNAL.[ 4].SLHVCVT.[4].GMESLFIEDLKDS 474 Dictyostelium discoideum
NP_188403 378 S.[8].VFEIAESLR.[3].WIIPAY.[10].VLRVVIR.[5].GLADRLITHIIQV 439 thale cress
NP_505372 439 T.[6].LYRFHNFMK.[3].WQLNGL.[ 4].GVHIMVT.[6].GLAEAFVADCRAA 493 Caenorhabditis elegans

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