Conserved Protein Domain Family
FNR_iron_sulfur_binding_2
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cd06216: FNR_iron_sulfur_binding_2 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Links
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Statistics
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PSSM-Id: 99812
Aligned: 32 rows
Threshold Bit Score: 246.753
Created: 23-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts primarily in the N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                                                                      #                 
YP_001158905  39 LPDDYLDLIAPLRAG.[2].LRGRIVEVRPETPD.[1].ATVVIQPGRD     WQGHRPGQYVRLGVDVNGVR.[1].W 102 Salinispora tropica ...
ZP_01307362   30 FFEPLIQWIKPNWRA.[2].CYTRVVSVRYESSD.[1].YTLQLKPLQS     FSHEFAGQYVELIIQKDGAW.[1].S 93  Oceanobacter sp. RED65
ZP_01132476   24 YLEPLVQQFKPAWRA.[2].YRAKVIKIITLPAN.[1].ISLELRPERS     WPSHQAGQHVLLSCQFNGRL.[1].T 87  Pseudoalteromonas tu...
YP_001186168  32 DVDLCLRLLHPALRL.[2].VFAQVEARRWVADD.[1].LAIELRCNGN     ARDWRAGQHVQLYLEQDGVR.[1].G 95  Pseudomonas mendocin...
ZP_01643509   33 LFDFWAGQLNPLWTL.[2].PVARLVRREPAGEG.[1].ATLVLRTNRH     WAGMRAGQHVTLGVEIEGRL.[1].Q 96  Stenotrophomonas mal...
NP_639219     32 LFDFWATRINPLWTL.[2].PMARLVARTPASRD.[1].VTLLFQPNGH     WQGLQAGQHVSIGVEIDGRR.[1].L 95  Xanthomonas campestr...
ZP_01916139   59 FVTFWLEQAGSTHST.[2].CLAEVVRIDRETAD.[1].VSLWLRPNAL     FKGFEAGQHVNLSITIDDVV.[1].T 122 Limnobacter sp. MED105
AAG08274      29 DVDGLLRHAHPLASL.[2].HYARVEARYWVADD.[1].LALALRTAPG     WPPVRPGQHIQLLAERDGVR.[1].G 92  Pseudomonas aerugino...
ZP_01612299   22 YIEPIMQVFKPAWRA.[2].FRAQLMSSESLNGE.[1].LSLQLKPSKQ     WPAHTAGQHVSLTIEMNGRL.[1].T 85  Alteromonadales bact...
ZP_01896398   22 YFSPFSTKPVAVLMG.[2].FAAKVVAIKPENND.[1].YSLTLAVSGK.[4].SFSFQPGQYVELQVKKNGSY.[1].K 89  Moritella sp. PE36


Feature 1        ####            ### #      ###                                              #  #
YP_001158905 103 RAYSVTS.[7].PITITVKAI.[2].GLVSNHLVRHA.[1].PGTIVQLDQAQGDFVLPA.[ 2].PARVLLVTAGSGIT 173 Salinispora tropica ...
ZP_01307362   94 RYFTISS.[9].TIELSIAIQ.[2].GRITPWLMKNL.[1].KGDMVNLGQPMGDFLPLN.[ 6].VSRKVFIAGGSGIT 170 Oceanobacter sp. RED65
ZP_01132476   88 RTFSISS.[9].HIRLTIKTA.[2].GAFTSQLANEL.[1].VGDFVNLSEPMGEFLLPS.[ 5].TDELFFIAAGSGIT 163 Pseudoalteromonas tu...
YP_001186168  96 RSYSLTR.[5].RIELAIKRQ.[2].GRLSNRLLDHL.[1].VGEVIELGQAFGDFAWPQ.[ 1].QGAVLLLAAGSGLT 163 Pseudomonas mendocin...
ZP_01643509   97 RSYSPTA.[4].ELAITVKAI.[2].GRVSQHLVNHA.[1].PGELFRLDAAFGEFQLPA      AAPVLLLAAGSGIT 162 Stenotrophomonas mal...
NP_639219     96 RSYSPTV.[4].RLAITVKAI.[2].GLVSTYLAGEA.[1].LGAVVSLDPAFGDMLLPT.[ 1].PAPLLLLAAGSGIT 162 Xanthomonas campestr...
ZP_01916139  123 RSYSFSC.[6].LVRLTIKQT.[2].GLVSRYVVNQL.[1].VGAVVELGDVFGDMTLAH.[ 8].RPTMLLLAAGSGIT 198 Limnobacter sp. MED105
AAG08274      93 RSYSLTR.[4].RLEIAVKRH.[2].GLLSPWLCEHL.[1].VGQRVELQPAQGDLRWPM.[ 1].AEAVCLLAAGSGLT 159 Pseudomonas aerugino...
ZP_01612299   86 RVFTVAS.[9].FIRLLIKTS.[2].GRFTGLLNNKA.[1].AGTWCNISAATGEFVFKN.[ 1].HTPATLIAGGSGIT 157 Alteromonadales bact...
ZP_01896398   90 RPFTISS.[9].TITLTIKKQ.[2].GRITPWLADAV.[1].KGDLFGISPAKGDFLLSA.[10].NKDVIFIAGGSGIT 170 Moritella sp. PE36


Feature 1                                                                                     
YP_001158905 174 PVMGMLRSG.[5].DVTLVHSAPTA.[1].DVIFGGALREL.[2].AGALRLVERH.[ 4].GQLSLADLAALVPDH 241 Salinispora tropica CNB...
ZP_01307362  171 PFRSSLQSL.[9].EIELFYYARSE.[1].HFLFREELQRC.[1].YLLPKAHVHF.[ 6].GFFDYTHLQVENKHQ 243 Oceanobacter sp. RED65
ZP_01132476  164 PFMAMLHTL.[9].NIYLCYFAKQG     EHLFIDELTEL.[3].IPRLNVMFLV.[ 3].GDSLASALKNVMPTS 234 Pseudoalteromonas tunic...
YP_001186168 164 PLLGLLRDA.[7].PVTLLHQVRRQ.[1].QQAFAEELQAL.[3].HANLQVRWAF.[ 5].GRLTAAQLAALPGEH 235 Pseudomonas mendocina ymp
ZP_01643509  163 PMRSLLREA.[7].PVDLFYWERTA.[1].HLQFRDELQAL.[3].HPNLRVHLLT.[ 3].GEAPAARIDTHDLLV 232 Stenotrophomonas maltop...
NP_639219    163 PMRALLQAA.[7].DVDLLYWVRQR.[1].EACFLDEFEAL.[3].HPRLRAQLLT.[ 3].GAAPAPRIDSFPLEQ 232 Xanthomonas campestris ...
ZP_01916139  199 PMISLIEEL.[7].DVTLMSWARNP.[1].DVLFDTSLKAK.[1].NEHFKYVRLL.[12].GRPSAEQFAAVAGAL 275 Limnobacter sp. MED105
AAG08274     160 PLLGLLREA.[7].PVLWLHYVRHP.[1].QRAWLGELEAL.[3].HPNLELRWSL.[11].GHFQPRHLDGWAADL 237 Pseudomonas aeruginosa ...
ZP_01612299  158 PMIAMLDDY.[6].AINLVYYAKSG     EHQCVDELREL.[3].FSNFSFLLLT      REQSSDITSNIKHWE 222 Alteromonadales bacteri...
ZP_01896398  171 PFHSLLMSH.[7].NFTLLYFVRAN     QHVLSDTLVAL.[3].HANFTLKLLH.[ 4].GYCSKAHINAITSEL 240 Moritella sp. PE36


Feature 1                                            # #
YP_001158905 242 .[ 4].TWACGPAGLLDALTAHWTAVG.[3].RLHTEQF 276 Salinispora tropica CNB-440
ZP_01307362  244 .[ 4].FFVCGPPAMIQHVRSTLNTHG.[4].NIYYEFF 279 Oceanobacter sp. RED65
ZP_01132476  235 .[ 1].VLICGPQQFKQDVDAVLNHFG.[4].NRQAEFF 267 Pseudoalteromonas tunicata D2
YP_001186168 236       LLLCGPRGFVEQACGWWRDAG.[3].SLQAESF 266 Pseudomonas mendocina ymp
ZP_01643509  233 .[11].VLACGPDGFVAAARERLAHQV.[1].GFQAEAF 272 Stenotrophomonas maltophilia R551-3
NP_639219    233 .[ 8].VMACGPGGFVQAARARLQDRV.[1].RFQAEAF 269 Xanthomonas campestris pv. campestris str. ATCC 33913
ZP_01916139  276 .[ 4].VYACGPDGFMNALRGILGDTP.[1].SFHAESF 308 Limnobacter sp. MED105
AAG08274     238 .[ 4].ALACGPAAFVEAVGEQLGARF.[1].GLQTESF 270 Pseudomonas aeruginosa PAO1
ZP_01612299  223 .[ 3].IYCCGPLGFMQRVQAFAQKHD.[1].NYYQEAF 254 Alteromonadales bacterium TW-7
ZP_01896398  241 .[ 4].VYICGPNSMMDSTQTLLLDMG.[4].AIHLEQF 276 Moritella sp. PE36

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