Conserved Protein Domain Family
LC_FACL_like

?
cd05914: LC_FACL_like 
Uncharacterized subfamily of fatty acid CoA ligase (FACL)
The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Statistics
?
PSSM-Id: 341240
Aligned: 6 rows
Threshold Bit Score: 626.007
Created: 1-Feb-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                     
NP_809597  25 TDYKGITLQYKDVARKIAKFHIVLESAG.[3].GDKIAVC.[1].RNSAHWGVTFLAT.[1].TYGAVIVPILHE.[3]. 92  Bacteroides
NP_603764  14 VTYGEEKYSYADIIKYVNYYSEFLDISK     GDRVALM.[1].ENRPESIFSFFSI.[1].AKKGIALSLDAG.[3]. 78  Fusobacterium nucleatum
NP_213682  12 LIHQGNEISYAELLENIASFANLMDITP     NERVGIV.[1].ENRPEWVYAFYGT.[1].KKGGIVVPIDFM.[3]. 76  Aquifex aeolicus
NP_604019  12 LYYKDIAVTYKEFILNTKKIKQFTKIKE.[1].TNNMIYM     ENRPELLYSFFAI.[1].DSRATCVCIDAS.[3]. 76  Fusobacterium nucleatum
NP_811067  25 DYGESVHYTYGQVAGEIARMHLLFKHCS.[3].GDKIAVI.[1].KNNAHWCIAYMAT.[1].TYGAIIVPILQD.[3]. 92  Bacteroides
YP_012330  27 SQLGCEPLTFRDLHDHAEHLALWLRDNG.[3].GDRVALL.[1].ENSPNWGIAYFAI.[1].GMGAIAVPILPE.[3]. 94  Desulfovibrio vulgaris

Feature 1                                       #                                           ##
NP_809597  93 DNIHNIVNHSEAKLLFVGD.[63].PEELAIINYTSGTTGYSKGVMLPY.[1].SIWSNVAYCFEM.[5].GDHIVSMLP 225 Bacteroides
NP_603764  79 EQLAFVLNDSKPKYIFVSN.[42].NEDLAVIVYTSGTTGNPKGVMITY.[1].NIKTNMEGVRAV.[5].TDVILAMLP 190 Fusobacterium nucleatum
NP_213682  77 QEIRYILEDAEPSIIFCSD.[36].EDDVAVLPYTSGTTGNPKGVMLTF.[1].NLMSNIRGVSEV.[5].EDKTLAILP 182 Aquifex aeolicus
NP_604019  77 VELTYYIDNSDVVKIFTTK.[46].KEDTALILYTSGTTGKPKGVMLTF.[1].NILANVDSLDVY.[5].TDVTIALLP 192 Fusobacterium nucleatum
NP_811067  93 NDVHHIVNHSESVFLFTSD.[64].NDKVMLLNYTSGTTGFSKGVMLTG.[1].NLAGNVTFGIRT.[5].GDKVLSFLP 226 Bacteroides
YP_012330  95 DAVQHILRHSEAKAVFVSE.[66].EDDVAAIIYTSGTTGHSKGVVLTH.[1].NIVWDADAVKSI.[5].GDRMLSILP 230 Desulfovibrio vulgaris

Feature 1                                                                     # ##  #      
NP_809597 226 MGHVFGM.[1].YDFLYGFSAGAHIYFL.[ 9].AQSFAEIKPRVISCVPLIVEKIIKKDILPRVDSKIGKLLLKVP 301 Bacteroides
NP_603764 191 YHHIMPL.[1].FTLILPMYMGVPIVLL.[10].ALQENRVTVILGVPRVWEMLDKAIMTKINQSSLAKFMFKMASK 267 Fusobacterium nucleatum
NP_213682 183 FHHMYPL.[1].TTMLLPLYLGATVVFL.[10].KLQKYQITVLIGVPRLYQLFHRRIMEEINKNVLAKNLFKLMKK 259 Aquifex aeolicus
NP_604019 193 LHHILPL.[1].GTGVMPLLYSATIVFL.[10].AMKKYKGTMMIGVPKLWEVMHKKIMDTINSKAITRFIFKLAKK 269 Fusobacterium nucleatum
NP_811067 227 LAHAYGC.[1].FDFLTATAVGTHVTLL.[ 9].MKAFEEVKPNLIITVPLVIEKIYKNVIQPLINKKGMKWALNIP 302 Bacteroides
YP_012330 231 LSHTYEC.[1].LGLVLPVLNGAHVHYM.[ 9].LPAMAQVRPTAMLSVPLVIEKIFKTALLPKLTGSWLKQRLYAI 306 Desulfovibrio vulgaris

Feature 1                    ##                      ######                                  
NP_809597 302 .[18].GGNFDEIIIGGAPFNAEVEAFL.[2].IGFPYTIAYGMTECGPIICSSRW.[2].LKLASCGKATTRMEVRID 386 Bacteroides
NP_603764 268 .[18].GGNIRLMVSGGAKIDKNILEDF.[2].MGFCAIQGYGMTETAPIITFNVP.[2].ERSDSAGEVIPNVEVKIA 352 Fusobacterium nucleatum
NP_213682 260 .[18].GGRIKYMVSGGAKLPLDIAQDL.[2].LGFTVIEGYGLTETSPIVSFNPP.[2].IKLGSVGVPIKGVEVMTT 344 Aquifex aeolicus
NP_604019 270 .[18].GGHIKFFVSGGSKLNPQITKDF.[2].LGIKICEGYGMTETSPIISYTPK.[2].IVFDSAGKVIKDVEVKIA 354 Fusobacterium nucleatum
NP_811067 303 .[18].GGRFKEIIIGGAAMNQEVEEFF.[2].IKFPFTIGYGMTECGPLISYAPW.[2].FILGSSGKVLDIMEARIY 387 Bacteroides
YP_012330 307 .[19].GGALRIFCIGGAGIAPDVERFL.[2].ANFPYAIGYGLTETAPLVAGSGP.[2].TRLTSTGFTLDGVDIAID 392 Desulfovibrio vulgaris

Feature 1                                         #               #  #        ####            
NP_809597 387 .[7].AGEIVCRGMNMMLGYYKNP.[9].NGWLHTGDLGTID.[1].EGYVTVRGRSKNLLLTSSGQNIYPEEIESKLNN 468 Bacteroides
NP_603764 353 .[1].DGEILVKGKNVMKGYYNNE.[9].DGWFHTGDLGKMD     GKYLIIIGRKKEMIVLPNGKNIDPNDIEAEIIK 427 Fusobacterium nucleatum
NP_213682 345 .[1].EGEIIVRGDNVMKGYWKKP.[8].NGWFYTGDLGEID.[1].EGYIYITGRKKEIIVLGSGKNVFPEEIESKILA 419 Aquifex aeolicus
NP_604019 355 .[1].DNEILVKGRNVMKGYYKNP.[9].DGWLHTGDLGKLV     NDYLYITGRKKEMIVLSNGKNINPIEIETKISS 429 Fusobacterium nucleatum
NP_811067 388 .[7].TGEIQVRGENVMVGYYKNP.[9].DGWLRTGDLGTMD.[1].SGNIFIRGRLKSMILSSSGQNIFPEELEAKLNN 469 Bacteroides
YP_012330 393 .[7].EGEIIVRGPNVMREYYKAP.[9].EGWFRTGDLGKFD.[1].DGYLYIKGRLKNVIIGPSGENIYPEEVEAIIHQ 474 Desulfovibrio vulgaris

Feature 1                                                         #                          
NP_809597 469 MP.[1].VAESLIVLQHDKLVALIYPD.[12].DIIKVMEANRVELNQQLPNYSQISKVKIHFEEFEKTAKKSIKRFMY 549 Bacteroides
NP_603764 428 NT     DLIKEIAVTEYKEQLLAIIY.[13].IKDAIKWEVIDKYNVTAPNYKKIHDIKIVKEELPKTRIGKIRRFML 508 Fusobacterium nucleatum
NP_213682 420 KA     PYIKEVGVFEKDGKLLALIY.[13].LEETIKWEVIDKVNRELPEWKRVVGFKIVKTELPKTRLGKLRRFLL 500 Aquifex aeolicus
NP_604019 430 MT     NLISEIVVTEYNSILTAVIH.[13].IYENLKWEVVDKYNQKTPDYKKILDVKIINEDFPKTKIGKIKRFMI 510 Fusobacterium nucleatum
NP_811067 470 LP.[1].ILESLVIERNKKLVALVYAD.[13].NLKTIMDENLKNLNNNVAAYEKVSKIQLYPTEFEKTPKRSIKRYLY 551 Bacteroides
YP_012330 475 SP.[1].VLESLVFQQDGRLVARIHLD.[18].KIDALLETLRNEVNTKVSTFARLAKVIEQTEPFEKTPTHKIKRYLY 561 Desulfovibrio vulgaris

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap