Conserved Protein Domain Family
STKc_SGK2
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cd05603: STKc_SGK2 
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270754
Aligned: 4 rows
Threshold Bit Score: 692.48
Created: 18-Oct-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:active site [active site]
Evidence:
  • Comment:The active site is composed of the ATP binding site and the substrate binding site. The ATP binding site is based on the binding of AMP-PNP to SGK1. The substrate binding site is based on the binding of peptide substrates to the AGC kinases, PKA and PKB.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1          ## #### #                # #                                #                #
NP_057360     99 KVIGKGNYGKVLLAKRKSD.[1].AFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLD 174 human
AAI25761      19 KVIGKGSFGKVLLAKRKCD.[1].NFYAVKVLQKKTILKKKEQNHIMAERNVLLKNLKHPFLVGLHYSFQTAEKLYFVLD 94  western clawed frog
EMC90577      27 KVIGKGSFGKVLLAKRKCD.[1].TFYAVKVLHKKTILKKKEQNHIMAERNVLLKNVKHPFLVGLHYSFQTSEKLYFVLD 102 domestic pigeon
NP_001107094  34 AVIGKGTFGKVLLAKLKAD.[1].KFYAVKVLQKKVILKKKEQKNIMAERNVLLKSLKHPFLVGLHYSFQTSEKLYFVLD 109 zebrafish


Feature 1         #   # #                                        # # ## #         ##  #          
NP_057360    175 YVNGGELFFHLQRER.[1].FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDT 250 human
AAI25761      95 YVNGGELFLHLQRER.[1].FLEPRARFYAAEVACALGYLHSQNIIYRDLKPENILLDSQGHVVLTDFGLCKEGMEPEET 170 western clawed frog
EMC90577     103 YVNGGELFFHLQRER.[1].FREPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGMEQEET 178 domestic pigeon
NP_001107094 110 YVNGGELFYHLQRER.[1].FSEPRARFYTAEVASAIGYLHSLNIVYRDLKPENILLDYQGHVVLTDFGLCKEGIEPEGT 185 zebrafish


Feature 1           ######                          #     #  #                                   
NP_057360    251 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQ.[2].SQMYENILHQPLQIPGG.[2].VAACDL 324 human
AAI25761     171 TSTFCGTPEYLAPEVLRKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR.[2].SQMYDNILSQPLQLPGC.[2].TATCDI 244 western clawed frog
EMC90577     179 TSTFCGTPEYLAPEVLKKQPYDRTVDWWCLGAVLYEMLFGLPPFYSR.[2].SQMYDNILHKPLHIQGS.[2].VAACDI 252 domestic pigeon
NP_001107094 186 TTTFCGTPEYLAPEVLRKEPYDRTVDWWCLGAVLHEMLYSLPPFYSR.[2].SEMYDAILHKPLHLPPG.[2].ESACLL 259 zebrafish


Feature 1                                                                                        
NP_057360    325 LQSLLHKDQRQRLG.[3].DFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD.[2].HFDPEFTQEAVSKSIGCTP 399 human
AAI25761     245 LRGLLHKDQRCRLG.[3].DFQEIKNHVFFSPINWDDLYHKRIAPPYNPNVAGPGD.[2].HFDPEFTQEAVPSSVGRTP 319 western clawed frog
EMC90577     253 LQGLLHKDQKRRLG.[3].DFLEIKNHVFFSPINWDDLYHKRITPPFNPNVAGPAD.[2].HFDPEFTQEAISTSITHTP 327 domestic pigeon
NP_001107094 260 LYGLLQKDQHRRTG.[3].DFLEIKNHVFFAPINWDDLYHKRITPPYNPNVRGPAD.[2].HIDPEFTREMVPHSVGRTP 334 zebrafish


Feature 1                         
NP_057360    400 D.[8].SSAFLGFSYAP 419 human
AAI25761     320 D.[8].SSAFLGFSYAQ 339 western clawed frog
EMC90577     328 D.[8].SDAFLGFSYAP 347 domestic pigeon
NP_001107094 335 E.[9].SNAFTGFSYIS 355 zebrafish

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