1BUD,3AIG,1IAG,1HTD,1HTD,1KUG,1WNI,1ND1,1KUK,1BSW,1DTH,4AIG,1QUA,1YP1,1R55


Conserved Protein Domain Family
ZnMc_adamalysin_II_like

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cd04269: ZnMc_adamalysin_II_like 
Click on image for an interactive view with Cn3D
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.
Statistics
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PSSM-Id: 239797
Aligned: 110 rows
Threshold Bit Score: 123.88
Created: 23-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Structure:1BUD: Deinagkistrodon acutus acutolysin binds water-coordinated Zn
    View structure with Cn3D
  • Citation:PMID 9784374
  • Structure:3AIG: Crotalus adamanteus adamalysin II binds Zinc and the peptidomimetic inhibitor Pol656
    View structure with Cn3D
  • Citation:PMID 9521103

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                   
1BUD_A      3 RYMEIVIVVD.[12].SIKAWVYEMINTITESYSY.[2].IDISLSGLEIWSGKDL.[ 6].AGNTLKSFGEWRAKDL 83  Deinagkistrodon acutus
DAA01537  213 KNVGIQYTVT.[12].ASIELILIMTSISHSIYKT.[2].MFVFARAACIWNDKDH.[ 9].VWRLMELFGYWKAGYF 296 house mouse
NP_033750 213 KSVGIHYTVT.[12].TSVELILIMNSISDSIYKI.[2].LIVYARGVWIWNTKNL.[11].PWSVMAGFGVWKSKEL 298 house mouse
AAN77878  215 AAIKGHFQAT.[13].STVEYLFKVISLMDTYLTN.[2].MRYYVFLMTVYTEADP.[ 7].PGGQAHTFYERVFYAH 297 house mouse
CAA60663  205 GNIKGHVQCS.[11].TCYIAVVQMFSVIDSIVQN.[2].LRYYIYLLTIYNVRDP.[ 5].YGANSAMFTYFKRTFF 283 crab-eating macaque
XP_548009 196 AMLKGFAQSS.[11].ACAKFLISMVSLIDSIYKG.[2].IRYHLTAVLIFHVRDP.[ 5].YRLPAGEYYRYHANNL 274 dog
XP_848365 190 MYASHHGQVK.[17].KCAQFLIRIFSLIDTFYQA.[2].MNYYIGSMIIYTQEEP.[ 5].FHPIQSPLARYYRSKL 274 dog
DAA01538  215 AAIKGHFQAT.[13].STVGYLFQVISLMDTYLTN.[2].MRYYVFLMTVYTNSDP.[ 8].GGSAYNYYVSVFYNKF 298 house mouse
CAA70328  215 AAIKGQFQAT.[11].TAARYLFELLSITDSFLIT.[2].MRYYAILLTVFTESDP.[ 8].GGSIYNYYVSNFFNRL 296 Norway rat
XP_849457 371 KMYASHNGYV.[18].KCAQFLIRIFSLIDTFYQA.[2].INYYIGSMIIYTQGES.[ 8].AHSPLARYYHSKVYPI 459 dog

Feature 1                                                               ##  #     #        
1BUD_A     84 .[5].HDNAQLLT.[8].IGLAYVASMCN.[1].KRSVGVIQDH.[ 4].RLVAITLAHEMAHNLGVSHDE.[2].C 154 Deinagkistrodon acutus
DAA01537  297 .[4].HATTALLL.[7].DYAGFQDGICN     PNWGVLYTYV.[ 5].FLAGSFLAHAVGHLLNVRHDT.[2].C 365 house mouse
NP_033750 299 .[4].ATTAILLA.[6].DYGSFQNGLCN     PNWGVLFTYV.[ 5].FLAGSFLAHAVGHLLDVSHDT.[2].C 366 house mouse
AAN77878  298 .[2].PDAGAIIN.[7].AVNPAERSICS     PSALICLGQH.[ 4].LFLSIIITNRVGRSLGLKHDE.[2].C 363 house mouse
CAA60663  284 .[5].HSSTLLIK.[6].NYEPQRYSFCT     HLGLLHIGTL.[ 4].LLVAVITTQTLMRSMGVEYDD.[2].C 351 crab-eating macaque
XP_548009 275 .[4].NPSSSFVL.[8].QNEPTFGGICS.[1].RCLHMIGLLG.[ 3].VLLAVIMSQYAARNLGLYYDN.[2].C 343 dog
XP_848365 275 .[4].LPHSTLIV.[8].NTEPIIYGLCK     TQNLLVLEYL.[ 4].LILSIIAAQKVGRSLGLYYDN.[2].C 343 dog
DAA01538  299 .[1].PDAGVLLN.[7].QVNPAERSICS.[1].LALICIGKYD.[ 3].LFLSPIITNRVGRSLGLKYDE.[2].C 363 house mouse
CAA70328  297 .[1].PDASTVLN.[7].DFHPVEQSLCT     PAGLTIVGQH.[ 4].LALSVMITNRIAMSLGIKADD.[3].C 362 Norway rat
XP_849457 460 .[1].LPHSTLIV.[1].KEGPLDNNTEP.[1].LYRFCKMQNL.[10].LILSIVAAQKVGRSFGLYYDN.[2].C 525 dog

Feature 1                                                    
1BUD_A    155 .[1].CG.[2].SCIMSP.[8].YFSDCSYIQCRDYIS.[5].CILN 197 Deinagkistrodon acutus
DAA01537  366 .[1].CF.[3].SCLMDE.[6].MISNCSHNELHRRIH.[4].CLSL 406 house mouse
NP_033750 367 .[1].CF.[3].SCLMDE.[6].MISNCSHNELHRRIH.[4].CLSL 407 house mouse
AAN77878  364 .[1].CQ.[3].TCIMFK.[6].AFSNCSLAEISNILN.[6].CLFY 406 house mouse
CAA60663  352 .[1].CQ.[3].FCIMQR.[6].AFSNCSYGHTQNCFV.[4].CVFE 392 crab-eating macaque
XP_548009 344 .[1].CQ.[3].TCIMYR.[6].SFSNCSFMHLQNLLS.[4].CLFN 384 dog
XP_848365 344 .[1].CQ.[3].TCIMNR.[6].AFSNCSFKHVLNILG.[5].CMYS 385 dog
DAA01538  364 .[1].CQ.[3].TCIMFR.[6].AFSNCSLAEISNILN.[6].CLFY 406 house mouse
CAA70328  363 .[1].CH.[3].TCIMYK.[6].AFSNCSLVQINQILN.[6].CLFY 405 Norway rat
XP_849457 526 .[1].CQ.[3].ICIMHK.[6].SFSNCSFMHLQHIVG.[5].CLYS 567 dog

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