1Z0N,2F15,2QLV,3NME


Conserved Protein Domain Family
E_set_AMPKbeta_like_N

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cd02859: E_set_AMPKbeta_like_N 
Click on image for an interactive view with Cn3D
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.
Statistics
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PSSM-Id: 199889
Aligned: 207 rows
Threshold Bit Score: 43.3565
Created: 14-Jul-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
glycogen
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:glycogen binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                #                                 #           #         #
1Z0N_C         12 PTVFRW.[3].GKEVYLSGSFNNW.[1].KLPXTRS.[4].VAILDL.[2].GEHQYKFFVDG     QWTHD.[6].TS 77   Norway rat
YP_003797269   35 GVRFVV.[4].AETVAVVGSFNGW.[3].AHIMTRV.[6].SAVVSL.[2].GEHAFMYLVDG.[1].TWVVP.[7].TD 107  Candidatus Nitrosp...
ZP_08005100    43 QVTFSY.[3].AQQVRVAGSFTGW.[3].ALAMTKG.[5].SKTIHL.[2].GVYEYKFILDD.[1].NWIAD.[2].NS 108  Bacillus sp. 2_A_5...
YP_004168000    8 SAVFTL.[5].VQEVLLKGSWNDW.[1].PEVMKRK.[5].SKTKRL.[2].GRYEFGYEIDG     VWRVD.[6].AS 76   Nitratifractor sal...
YP_002952871  119 EVTFVA.[4].AQQVAVIGSFNDW.[3].RHVMHKA.[6].SLTVNL.[2].GRYVYAFLVDG     TLLET.[8].DD 191  Desulfovibrio magn...
CBX27334       14 KVTFII.[4].AEKVSLIGDFNKW.[3].THTMKKE.[7].SIFLDP     GRYEYKFQVDG     QWQTD.[7].QN 84   uncultured Desulfo...
ZP_07198537    18 RVTLNF.[4].AESVLLMGDFNQW.[3].RHPMKQG.[5].EKIIVV.[2].GRYEYRFLVDG     MWQND.[7].SN 88   delta proteobacter...
YP_002509570   36 EVTFTY.[4].AEEVYLIGQMNGW.[5].AMKMEMN.[5].EITITL.[2].GVYEYKFFVDG     EYKTD.[3].PE 104  Halothermothrix or...
YP_002601616   14 RIEFTF.[4].ATEVMIFGDFNKW.[3].KHRMKKG.[5].KKTLVL.[2].GTYEYKYRVDG     KWQED.[7].LN 84   Desulfobacterium a...
YP_847990     132 QVVLAL.[4].ARSVAVMGSFNGW.[1].AEPCEPR.[8].TVTLQL.[2].GRYEYAFVVDG     KKIIP.[8].ED 204  Syntrophobacter fu...

Feature 1         ## # #     
1Z0N_C         78 QLGTVNNIIQV 88   Norway rat
YP_003797269  108 GFGNTNGVVTV 118  Candidatus Nitrospira defluvii
ZP_08005100   109 KTGNGNSLLAI 119  Bacillus sp. 2_A_57_CT2
YP_004168000   77 PFGSQNSLLEV 87   Nitratifractor salsuginis DSM 16511
YP_002952871  192 GFGHTNSVLII 202  Desulfovibrio magneticus RS-1
CBX27334       85 NFGTYNNYIVV 95   uncultured Desulfobacterium sp.
ZP_07198537    89 CFGSNNNILEI 99   delta proteobacterium NaphS2
YP_002509570  105 TTGPYNNSVAR 115  Halothermothrix orenii H 168
YP_002601616   85 PFGTYNNLLTV 95   Desulfobacterium autotrophicum HRM2
YP_847990     205 GFGNHNAVLLV 215  Syntrophobacter fumaroxidans MPOB

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