1TOT


Conserved Protein Domain Family
ZZ_CBP

?
cd02337: ZZ_CBP 
Click on image for an interactive view with Cn3D
Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that provides binding sites for transcriptional coactivators, the role of the ZZ domain in CBP/p300 is unclear.
Statistics
?
PSSM-Id: 239077
Aligned: 11 rows
Threshold Bit Score: 68.3587
Created: 29-Mar-2005
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zinc-binding sites [ion binding site]
Evidence:
  • Comment:6 conserved cysteines and 2 conserved histidines coordinate 2 zinc ions
  • Structure:1TOT: ZZ domain binds zinc
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1        #  #                 #  #     #  #          # #     
1TOT_A       7 YTCNECK.[1].HV.[1].TRWHCTVCEDYDLCINCYNT     KSHTHKMVKW 47   house mouse
XP_148699 1687 YTCNECK.[1].HV.[1].TRWHCTVCEDYDLCINCYNT     KSHTRNPGVS 1727 house mouse
P34545    1497 YTCNKCS     SP     AVWHCQSCDDFDLCDGCKPT     TQHPHEMEKI 1535 nematode
CAF95299  1728 YTCNECK.[1].HV.[1].TRYHCTVCEDYDLCITCYNT     KGHVHKMDKL 1768 Tetraodon nigroviridis
XP_416238 2396 YTCNECK.[1].HV.[1].TRWHCTVCEDYDLCITCYNT     KNHDHKMEKL 2436 chicken
AAH86282  1696 YTCNECK.[1].HV.[1].TRWHCTVCEDYDLCVNCYSA     KNHEHKMVKW 1736 African clawed frog
T13828    2333 YTCNHCK.[1].AV.[1].TRYHCTVCDDFDLCIVCKEK     VGHQHKMEKL 2373 fruit fly
AAL54859  1614 YTCNSCK.[1].AV.[1].TRYHCSTCDDFDLCVPCYNK     EGHHHKMTKL 1654 California sea hare
Q09472    1668 YTCNECK.[1].HV.[1].TRWHCTVCEDYDLCITCYNT     KNHDHKMEKL 1708 human
EAL41310  1331 YTCNNCK.[1].HV.[1].TRYHCTVCDDFDLCITCKEK     VGHQHKMDKL 1371 Anopheles gambiae str. PEST
AAC17068  1378 TTCNACH.[2].IE.[2].QGWRCEVCPDYDVCNACFSR.[3].VNHPHKLTNH 1423 thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap