1ELZ,3Q3Q,1EJJ,4FDJ,2XR9,3UN2,1HDH,2D1G,4KAY,2W5Q,1P49,3IDD


Conserved Protein Domain Family
ALP_like

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cd00016: ALP_like 
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alkaline phosphatases and sulfatases.
This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Statistics
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PSSM-Id: 293732
Aligned: 22 rows
Threshold Bit Score: 76.3053
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1EJJ; Geobacillus stearothermophilus Phosphoglycerate Mutase binds to 3-Phosphoglycerate and 2 Mn++, defined by 4A distance.
    View structure with Cn3D
  • Structure:3Q3Q; Sphingomonas Sp Alkaline Phosphatase binds to methyl phosphate and Zn++ at active site, defined by 4A distance.
    View structure with Cn3D
  • Structure:4FDJ; human GALNS binds N-Acetyl-D-Galactosamine and Ca++ at active site, defined by 4A distance.
    View structure with Cn3D
  • Structure:1HDH; Pseudomonas aeruginosa Arylsulfatase binds Ca++ and phosphate at active site, defined by 4A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1             #                             #                                     
1ELZ_A     43 KNIILLIGDGMGD.[23].PLTG     QYTH.[15].GAASATAWSTGV.[ 17].TILEMAKA.[3].ATGNVS 147 Escherichia coli
1EJJ_A      4 KPVALIILDGFAL.[23].YPHT     TLKA.[14].SEVGHLNIGAGR.[242].TIGEVLSQ.[3].RQLRIA 332 Geobacillus stearothermophilus
4FDJ_A      5 PNILLLLMDDMGW.[22].GLLF.[1].NFYS.[ 4].XSPSRAALLTGR.[ 32].LLPELLKK.[3].VSKIVG 113 human
2XR9_A    128 PPLIIFSVDGFRA.[19].GTHA.[1].YMRP.[ 5].TFPNLYTLATGL.[ 37].PLWITATK.[3].RAGTFF 239 Norway rat
1HDH_A      5 PNFLVIVADDLGF.[21].GLRL.[1].DFHT.[ 3].XSPTRSMLLTGT.[ 33].ALPELLRE.[3].QTLMAG 112 Pseudomonas aeruginosa
4KAY_A     23 RFVVLVVGETTRA.[22].IVNF.[1].QVRS.[ 4].XAHSLPCMFSTF.[ 14].NLLDIVQR.[3].EVTWLE 113 Neisseria meningitidis MC58
2W5Q_A     30 KNIIKIHLESFQT.[25].FTYF.[1].NFFH.[ 6].TSDSEFTMDNSL.[ 18].SLPAILDQ.[4].KSDVMH 130 Staphylococcus aureus
1P49_A      6 PNIILVMADDLGI.[22].GVKL.[1].QHLA.[ 4].XTPSRAAFMTGR.[ 30].TFAKLLKD.[3].STALIG 112 human
3IDD_A      6 KSIILIVLDGLGD.[26].GING     IXHP.[ 8].SDTSHXSLLGYD.[162].SFTEKNRX.[1].GACVVG 249 Thermoplasma acidophilum
NP_650920 293 PSVLLWGIDSISR.[16].QHWF     ELQG.[ 7].TFPNLMAVLTGF.[ 21].FIWKDFKD.[2].YTTAFA 385 fruit fly

Feature 1                                     #                                      ##  
1ELZ_A    148 .[155].TDKAIE.[ 8].FFLQVEG.[2].IDK.[ 8].GQIGETVDLDEAVQRALE.[6].NTLVIVTADHAH 372 Escherichia coli
1EJJ_A    333 .[ 50].LLKEIE.[ 4].DAIILNY.[2].PDM.[ 8].PTIKAVEAVDECLGKVVD.[5].GGIAIITADHGN 447 Geobacillus stearothermophilus
4FDJ_A    114 .[ 73].ALDFIK.[ 7].FFLYWAV.[2].THA.[15].RYGDAVREIDDSIGKILE.[9].NTFVFFTSDNGA 265 human
2XR9_A    240 .[ 10].ILTILQ.[10].SVYAFYS.[2].PDF.[10].EMTNPLREIDKTVGQLMD.[9].CVNVIFVGDHGM 326 Norway rat
1HDH_A    113 .[ 75].LLQYLK.[ 7].FFAYLPF.[2].PHW.[69].VYAAMVERMDWNIGRVVD.[9].NTFVLFMSDNGA 320 Pseudomonas aeruginosa
4KAY_A    114 .[ 35].LLTKFD.[ 9].AVLILHT.[2].SHG.[33].TYDNTVLYVDQFIDKVIR.[8].ESVVHYVSDHGE 246 Neisseria meningitidis MC58
2W5Q_A    131 .[ 44].FKDSAN.[ 8].FYSHLIT.[2].NHY.[22].GYIQTARYLDEALEEYIN.[9].NSVIMIYGDHYG 261 Staphylococcus aureus
1P49_A    113 .[134].AAQFIQ.[ 6].FLLVLSY.[2].VHT.[15].VYGDAVEEMDWSVGQILN.[9].DTLIYFTSDQGA 324 human
3IDD_A    250 .[ 32].IEKAVD.[ 5].DFVLVNI.[2].TDV.[ 8].LKRDVIEDIDRAXEPLKS.[3].HAVICVTGDHST 345 Thermoplasma acidophilum
NP_650920 386 .[ 56].IYDMGV.[10].FFGMFWT.[2].FSH      NDFSMPSAMDERMVKYMR.[9].NTIIIFFSDHGS 508 fruit fly

Feature 1                                            
1ELZ_A    373 .[ 43].QLRIAAY.[ 9].LTD.[1].TDLFYTMKAAL 446 Escherichia coli
1EJJ_A    448 .[ 18].PVPVIVT.[ 8].GGI.[1].GDLAPTMLDLL 495 Geobacillus stearothermophilus
4FDJ_A    266 .[ 27].REPALAW.[13].LGS.[1].MDLFTTSLALA 327 human
2XR9_A    327 .[122].QTVFVGY.[11].PFE.[1].IELYNVMCDLL 481 Norway rat
1HDH_A    321 .[ 63].RVPALVR.[13].FAT.[1].MDVTPTLLDLA 418 Pseudomonas aeruginosa
4KAY_A    247 .[ 22].HIPMVMW.[23].EYS.[1].DHYFSTVLGLM 313 Neisseria meningitidis MC58
2W5Q_A    262 .[ 26].RTGFWIK.[11].YAG.[1].VDVMPTILHLA 320 Staphylococcus aureus
1P49_A    325 .[ 31].RVPGILR.[13].PTS.[1].MDIFPTVAKLA 390 human
3IDD_A    346 .[ 10].PVPIVFY.[22].RIT.[1].YNVXDILXQLA 399 Thermoplasma acidophilum
NP_650920 509 .[ 15].RLPFIYI.[23].LTS.[1].YDIHATLRHIL 568 fruit fly

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