2E8A,1DKG,1E4G,1GLF,1HUX,1MWM,2AA4,2D0O,2E2N,2HF3,3B8A,3CJ1,3ENH,3HRG,3MK6,3QBX,3T69,5LJV,6PC0,4CZL,1X3M,4O5F,4BGA,1X9J,4PHT,2Q2R


Conserved Protein Domain Family
ASKHA_ATPase-like

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cd00012: ASKHA_ATPase-like 
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ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily
The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I & II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.
Statistics
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PSSM-Id: 466786
Aligned: 26 rows
Threshold Bit Score: 1e+06
Created: 1-Nov-2000
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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2E8A_A  10 IGIDLG.[2].YSCVGV.[120].NAVITVP.[ 21].VLRII.[ 1].EPTAAAI.[14].LIFDLG.[2].TFDVSI 212 human
1GLF_Y   7 VALDQG.[2].SSRAVV.[ 55].AIGITNQ.[156].ISGIA.[ 1].DQQAALF.[ 9].AKNTYG.[1].GCFMLM 273 Escherichia coli
2AA4_A   4 LAIDIG.[2].KLAAAL.[ 40].RVAIAST.[ 34].PTIAI.[ 1].DAQAAAW.[13].VFITVS.[1].GVGGGV 137 Escherichia coli
3B8A_X  83 LAIDLG.[2].NLRVVL.[ 55].PLGFTFS.[ 46].IVALI.[ 1].DTVGTLI.[10].MGVIFG.[1].GVNGAF 240 Saccharomyces cerevisiae S288c
3ENH_A   9 LGLEGT.[2].KTGVGI.[ 52].LIAFSQG.[ 23].PIIGV.[ 1].HCIAHIE.[11].LTLYVS.[2].NTQVIA 142 Methanocaldococcus jannaschii
3HRG_A  13 LSIRLS.[2].GFSFSI.[ 41].RVNIXIA.[ 62].EARFY.[ 1].QSTPLIE.[13].XYASVR.[2].AIDIYC 176 Bacteroides thetaiotaomicro...
3QBX_B   5 LGLMSG.[4].GMDIVL.[ 69].AIGSHGQ.[ 26].DVVAD.[15].VPAFHQA.[ 9].AVLNIG.[1].FSNVSL 171 Pseudomonas aeruginosa
1X3M_A  21 LVINCG.[2].SIKFSV.[ 60].LIGHRIA.[ 48].RQVAV.[36].SHRYVSR.[15].IVAHLG.[1].GASICA 225 Salmonella typhimurium
4O5F_A  27 LLIDAG.[2].RIKWAL.[ 29].GAWISNV.[ 20].PRTVV.[21].DRWAGLI.[11].LIATFG.[1].ATTLEA 153 Burkholderia thailandensis ...
4PHT_X   6 LTVRLS.[5].PIPWLV.[ 30].PIVVLVA.[ 73].VKRVL.[ 1].DSLALPL.[ 5].SAAQLG.[1].QWLFRH 163 Vibrio vulnificus CMCP6

2E8A_A 213 .[123].DLVLVGG.[29].VAYGAA 377 human
1GLF_Y 274 .[131].ALRVDGG.[27].TALGAA 444 Escherichia coli
2AA4_A 138 .[ 98].CVVVGGS.[35].GLLGAA 283 Escherichia coli
3B8A_X 241 .[172].HIAADGS.[39].SGAGAA 464 Saccharomyces cerevisiae S288c
3ENH_A 143 .[108].EVMLVGG.[32].NGAMIA 295 Methanocaldococcus jannaschii
3HRG_A 177 .[ 38].ELHLTGT.[27].DXQALL 254 Bacteroides thetaiotaomicron VPI-5482
3QBX_B 172 .[114].EVLVCGG.[33].EGMAFA 331 Pseudomonas aeruginosa
1X3M_A 226 .[107].GIIFTGG.[54].EEKMIA 399 Salmonella typhimurium
4O5F_A 154 .[ 89].RLVLSGG.[19].VLTGLA 274 Burkholderia thailandensis E264
4PHT_X 164 .[ 26].SVACFSS.[21].LSQGVA 223 Vibrio vulnificus CMCP6
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