Conserved Protein Domain Family
ELP3
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TIGR01211: ELP3 
radical SAM enzyme/protein acetyltransferase, ELP3 family
This family includes elongator complex protein 3 (ELP3) from eukaryotes and related proteins from other lineages. ELP3 is a component of the RNA polymerase II holoenzyme. It has an N-terminal radical SAM domain and C-terminal GNAT acetyltransferase domain. Members of this family are found in eukaryotes, archaea, and a few bacteria (e.g. Atopobium sp). The activity discovered first was an acetyltransferase modification at the N-termini of all four core histones, shown in vitro in eukaryotes. More recently, the radical SAM domain was shown to play a role in zygotic paternal genome demethylation. Family TIGR01212, widespread in prokaryotes, lacks the GNAT acetyltransferase domain but shares extensive sequence similarity with this family (TIGR01211). [Transcription, DNA-dependent RNA polymerase]
Links
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Statistics
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PSSM-Id: 273503
Aligned: 7 rows
Threshold Bit Score: 870.605
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Q58536        18 RILDEYNKGKTL.[1].KKRIEQIKAECLRIHRIGI.[1].HPSNSEILQYATEEEK.[2].LIPILRKKPVRTISGVAV 86  Methanocaldococcus j...
AAB68213      32 ELTDSLTSGTTR     EINLNGLITKYSKKYKLKQ     QPRLTDIINSIPDQYK.[2].LLPKLKAKPVRTASGIAV 98  baker's yeast
WP_010876452  17 LIINGIISGEIR.[1].RKDLERFKHRVCREMGLER     FMSNSEILEHATPEEK.[2].IEGLLRKKPTRTISGVAV 84  Methanothermobacter ...
WP_010885926  38 EIVEALLSGKVK.[1].REELNKLKIEVARKYHLPK     LPKNSDIWKALPKDKR.[2].FRDLLKKKPARTISGVAV 105 Pyrococcus horikoshii
WP_010903101  16 ELVSRILAGDVG     KDDIEDAKLDVCGEYAASK     VPKHSDLLDVAPDGRR.[2].LEDVLQRKPVRTASGVTP 82  Halobacterium salinarum
WP_010901717   6 EMRDVLLSGQIK.[1].KEDLEDVKLELSKKYGLDY     VPSDVEILNSFNFSED     VKKILRRKPTRTISGVAV 71  Thermoplasma acidoph...
WP_010879889   2 FELAKEIAENAR.[1].KEEVLRIKRLFARRHGLST     IPSDAEILRAAKGTEL.[3].LREILRVKPVRTISGVAV 70  Archaeoglobus fulgidus


Q58536        87 VAVMTSPEKCPHGK     CIFCP.[8].DVPQSYTGREPATMRGLMFNFDPYLQTKARIEQLEKVGHPTNKIELIIMGG 164 Methanocaldococcus j...
AAB68213      99 VAVMCKPHRCPHIA.[5].CVYCP.[8].YSTQSYTGYEPTSMRAIRARYDPYEQARGRVEQLKQLGHSIDKVEYVLMGG 181 baker's yeast
WP_010876452  85 VAVMCQPRECPHGR     CLYCP.[3].KAPPSYTGEEPAALRARMYDFHPYRQVYNRLEQLHSIGHPVDKVELIVMGG 157 Methanothermobacter ...
WP_010885926 106 VAMMTKPFPCPHGR     CIYCP.[5].GSPQSYTGKEPSALRASQYGYHPYIIMMARLKQLYDIGHPIDKVEVIIQGG 180 Pyrococcus horikoshii
WP_010903101  83 VAIMTSPHTCPHGK     CLYCP.[7].TSSQSYTGHEPAAARGVQNDYDPYGQVTLRLHQLRQIGHPVDKVELILMGG 159 Halobacterium salinarum
WP_010901717  72 VAAMTSPERCPHGK     CIFCP.[5].NSPQSYTGYEPAALRGRNNAYDPYMETFNRIKQLETIGHDTSKIDLIIMGG 146 Thermoplasma acidoph...
WP_010879889  71 VAVMTSPAPCPHGK     CLPCP.[5].NTPQSYVGLEPAAMRGRQHGYDAFKQVTARLRELESIGHDVSKVEIIVMGG 145 Archaeoglobus fulgidus


Q58536       165 TFPARDIEYQDWFIKRCLDAMNG      VDASS      LEEAQKINETAEHRCVALCIETRPDYCGEKEINQMLKLGA 232 Methanocaldococcus j...
AAB68213     182 TFMSLPKEYREDFIVKLHNALSG      FNGND      IDEAILYSQQSLTKCVGITIETRPDYCTQTHLDDMLKYGC 249 baker's yeast
WP_010876452 158 TFPSHSLCYQEWFISMCLKAMVD.[ 4].LRGIR.[11].VEDAQRLNESSPVRCVGMTFETRPDYCREEDVDRMLGLGV 240 Methanothermobacter ...
WP_010885926 181 TFPAVDLDYQEWFVKCAFKAMND.[18].LKGDK.[23].LEDEQRKNEKAKVRMVGLTIETRPDWAFERQIDRMLSFGT 289 Pyrococcus horikoshii
WP_010903101 160 TMTARSHDYQEWFVKRALQALND.[ 6].PAPNQ.[15].LEDVIADNEHGALRNIGTTFETKPDWCDPEQVDRMLDLGA 248 Halobacterium salinarum
WP_010901717 147 TFTARDPAYQRNFVKGCLDAMNG      SIGNS      LEESIRINETSRHRCIGLTVETKPDWFFEREIDEALAYGT 214 Thermoplasma acidoph...
WP_010879889 146 TFPARDADYKEKFMLGIFNALNS.[ 4].TKPEN.[ 1].LERAKRKNERAKARCVGITFETRPDYAREEHIREMLRFGG 218 Archaeoglobus fulgidus


Q58536       233 TRVELGVQTIYNEILEFCKRGHTVEDTIKATQLLKDSGLKVSYHLMPGMP.[1].SDMEMDKKMFKEIFENPDFKPDMVK 308 Methanocaldococcus j...
AAB68213     250 TRLEIGVQSLYEDVARDTNRGHTVRSVCETFAVSKDAGYKVVSHMMPDLP.[1].VGMERDIEQFKEYFENPDFRTDGLK 325 baker's yeast
WP_010876452 241 TRVELGVQTIYNYIYQRIKRGHSIRDVVESNRILRDSGVKVAMHLMPGLF     SDFERDLRIFRRIFRDPSFRPDMIK 315 Methanothermobacter ...
WP_010885926 290 TRVELGVQTIFNFIHERTKRGHGVEEIIKATQLLKDAGLKVNYHIMPGLP.[1].SNFDRDLYTFRTIFEDPRFRPDMLK 365 Pyrococcus horikoshii
WP_010903101 249 TKVEVGVQTTFERVNREMHRGHGVQASVDANRRLRDAAFKVGFHMMPGQP.[1].MSKEMVLEDFRRLFDDERWKPDYLK 324 Halobacterium salinarum
WP_010901717 215 TKVELGVQNIDDRILAINNRGHTVADIARSTQLARDAGLKIVYHIMPGMY.[1].SSFEKDLKSFDLMINDERFKPDMLK 290 Thermoplasma acidoph...
WP_010879889 219 TKVELGVQSLYDDVLERIKRGHGVKEVAEATRLLRDSAFKVGYHIMPGLP.[1].SSFERDLRMFRELFENDSFKPDYLK 294 Archaeoglobus fulgidus


Q58536       309 IYPCLVIEGTELYEMWKRGEYKPYREEEAIEIISYAKSIMPKWVRTSRIQRDIPATVIV.[1].GVKKSNLGELVYKYME 384 Methanocaldococcus j...
AAB68213     326 IYPTLVIRGTGLYELWKTGRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVT.[1].GVDNGNLRELALARMK 401 baker's yeast
WP_010876452 316 IYPCLVTRGSELYSLWERGLYKPYSTEEAVELIVEIKKMMPKWVRTMRIQRDIPSRLIV.[1].GVRKSNLGEMVYRRLE 391 Methanothermobacter ...
WP_010885926 366 IYPTLVTRDAPLYAWYKAGLYRPYTTEEALELLVEAYKIFPKWVRVMRIQRDIPAHLIV.[1].GVKHSNLGQLVFNELV 441 Pyrococcus horikoshii
WP_010903101 325 IYPTLVVRDTITYDMWRNGDFEPLHNEEAADLVAEIKDMIPRYTRLQRVQRDIPADFID.[1].GVWKSNLRQLARQRMA 400 Halobacterium salinarum
WP_010901717 291 IYPTLVTQGTGLYNLWKNGKYRPYTTAETVDLIVEFMRRMPDWIRIQRIQRDIPVQFIV.[1].GVKRSDIRNLVERRMR 366 Thermoplasma acidoph...
WP_010879889 295 IYPTLVVEGTELYEMWKRGEYEPYTTEEVVELIVMAKRRFPEWVRVQRIQRDIPVKAAI     GLDKGNIRQLVHRRLK 369 Archaeoglobus fulgidus


Q58536       385 KHGIKCKCIRCREVGHVMYK.[7].EHIKLCREEYEASGGTEIFLSYEDVKN.[1].ILIAFLRLREPYKP     FRKE 457 Methanocaldococcus j...
AAB68213     402 DLGTTCRDVRTREVGIQEVH.[5].DQVELIRRDYYANGGWETFLSYEDPKK.[1].ILIGLLRLRKASKK.[1].TYRK 473 baker's yeast
WP_010876452 392 EEGVRCRCIRCREVGHMSRR.[6].DAVTLMVEEYAATGGREFFLSQEDPEN.[1].VLVGFLRLRFPSEE     AHRP 463 Methanothermobacter ...
WP_010885926 442 RRGIRPREIRFREVGHQMQK.[7].EHIKLLREDYEASEGQEIFLSFEDVKN.[1].ILIGFLRLRIPSEK     AHRK 514 Pyrococcus horikoshii
WP_010903101 401 EHGYTCDCIRCREAGMNDDD.[1].ENVSLDVETYAAGGGTEQFISIEDFQQ.[1].LLVGFARLRFPNEP     AREE 467 Halobacterium salinarum
WP_010901717 367 EEGIKTGEIRYREIGHGTVK.[1].ENVILKVEGYNAGGGKEYFISYVTESN     RIIGFVRLRIPSDR     AHRQ 432 Thermoplasma acidoph...
WP_010879889 370 EMGYSCRCIRCREVGHKGVR.[4].SKAELVVREYVASEGREFFISFEIPEY.[1].ALVGFVRLRFPKEP     FIEV 439 Archaeoglobus fulgidus


Q58536       458 IDDN.[1].MLVRQLHVCGQEKPLT     K.[2].KEITWQHKGYGRKLLEEAER.[1].AKEE.[1].GKKKILVTSG 517 Methanocaldococcus j...
AAB68213     474 EFTS.[3].SIVRELHVYGSVVPLH     S.[1].DPRKFQHQGFGTLLMEEAER.[1].AKEE.[1].GSEKISVISG 534 baker's yeast
WP_010876452 464 EVDD.[2].ALVRELHVYGSMLPIG     E.[1].GDAVGQHRGYGEELLARAES.[1].AADN     GMEKILVTSG 522 Methanothermobacter ...
WP_010885926 515 EINC.[3].AIVRELHVYGPLVPIG     E.[1].PKYEWQHRGYGRELLSEAER.[1].AREE.[1].DAKKILVISG 575 Pyrococcus horikoshii
WP_010903101 468 LTDA     ALLRELHVYGSEVSVG.[1].D.[1].GDDQHQHQGYGRQLMERAEH.[1].AADS     GFEKLSVISG 525 Halobacterium salinarum
WP_010901717 433 EVMN.[1].AIIRELKVFGQEVPVG     R.[1].EEDEWQHRGFGNRLVQEAER.[1].TLEE     GLHRILVISG 490 Thermoplasma acidoph...
WP_010879889 440 LRDA     ALIRELHVYGRAVPIG     Q     SSDAFQHRGFGERLLKEAEE     IAKE     EYDRIAVISG 494 Archaeoglobus fulgidus


Q58536       518 IGVREYYR     KLGYERVGAYMGKYL 540 Methanocaldococcus jannaschii DSM 2661
AAB68213     535 VGVRNYYG     KLGYELDGPYMSKRI 557 baker's yeast
WP_010876452 523 IGAREYYS     KFGYLKEGPYMAKKL 545 Methanothermobacter thermautotrophicus
WP_010885926 576 VGVREYYR     KFGYRKDGPYVSKRL 598 Pyrococcus horikoshii
WP_010903101 526 IGARQYYK.[1].QLGYHQDGPYVSKRL 549 Halobacterium salinarum
WP_010901717 491 IGVREYFR     KRGYEDLGPYVAKRL 513 Thermoplasma acidophilum
WP_010879889 495 VGVRDYYR     KLGYRLRQGYMVKKL 517 Archaeoglobus fulgidus
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