Conserved Protein Domain Family
gyrB
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TIGR01059: gyrB 
DNA gyrase, B subunit
This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. Proteins scoring above the noise cutoff for this model and below the trusted cutoff for topoisomerase IV models probably should be designated GyrB. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273421
Aligned: 14 rows
Threshold Bit Score: 721.835
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

O67137     12 YTAEAIKAVSGLEHVRLRPAMYIGDIGE     RGLHHLIWEILDNAVDEAVAGYARNISVTIHRDNSVTVEDDGRGIPV 86   Aquifex aeolicus VF5
P05652      8 YDENQIQVLEGLEAVRKRPGMYIGSTNS     KGLHHLVWEIVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPV 82   Bacillus subtilis subs...
P77966      8 YGADQIQVLEGLEPVRKRPGMYIGSTGP     KGLHHLVYEVVDNAIDEALAGYCTHIEIDINADGSVTVVDNGRGIPT 82   Synechocystis sp. PCC ...
P43701      9 YGASSIKVLKGLDAVRKRPGMYIGDTDD.[1].TGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGGGIPV 84   Haemophilus influenzae...
O08399      5 YSASSITVLEGLEAVRKRPGMYIGSTGP     NGLHHLVYEVVDNCIDEAMAGYCDRITVVLEQGNVVRVEDNGRGIPV 79   Treponema pallidum sub...
P33769      3 YVASNIQVLKGLEAVRKRPGMYIGSVSI     NGLHHLVYEVVDNSIDEALAGFCDRIDVIINLDNTITVIDNGRGIPT 77   Borrelia burgdorferi B31
P47249     10 YDSSSIKVLEGLEAVRKRPGMYIGSTGE     EGLHHMIWEIVDNSIDEAMGGFASFVKLTLEDNFVTRVEDDGRGIPV 84   Mycoplasma genitalium G37
P22447     10 YDSSSIKILEGLEAVRKRPGMYIGSTGE     EGLHHMIWEIIDNSIDEAMGGFASTVKLTLKDNFVTIVEDDGRGIPV 84   Mycoplasma pneumoniae ...
Q9ZCX2     13 YSADSIKVLKGLEAVRKRPGMYIGDVGD.[1].SGLHHMIYEVVDNSIDEALAGYCDLVQVTLNKNGSVTVSDNGRGIPV 88   Rickettsia prowazekii ...
ETW21911   12 YGAASITILEGLEAVRKRPGMYIGSTGE     RGLHHLIWEVVDNAVDEAMAGYAATVSVVLLEDGGVEVTDDGRGIPV 86   Mycobacterium gastri '...


O67137     87 DIHPE.[1].GKPAVEMVFTMLGAGGKFEKKVYTYSGGLHGVGASVVNALSEWLIVEVYRDGKIYRMAFKRG     EVV 157  Aquifex aeolicus VF5
P05652     83 GIHEK.[1].GRPAVEVIMTVLHAGGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRG     VPV 153  Bacillus subtilis subs...
P77966     83 DIHPT.[1].GRSALETVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSEWVEVKVWRQGKEHFQRFERG     NPI 153  Synechocystis sp. PCC ...
P43701     85 DIHPE.[1].GVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLG     EPQ 155  Haemophilus influenzae...
O08399     80 DVHPH.[1].GVSALEVVLTKLHAGGKFDKKSYKVSGGLHGVGVSVVNALSLWVEVTVYRDGAEYYQKFNVG     MPL 150  Treponema pallidum sub...
P33769     78 DIHEE.[1].GISALELVLTKLHSGGKFNKGTYKVSGGLHGVGISVVNALSSFLEVYVNRDGKIFRQTFSKG     IPT 148  Borrelia burgdorferi B31
P47249     85 DIHPK.[1].NRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVFRQNKKYFLSFSDG.[1].KVI 156  Mycoplasma genitalium G37
P22447     85 DIHPK.[1].NRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVAREHQQYFLAFHNG.[1].EVI 156  Mycoplasma pneumoniae ...
Q9ZCX2     89 EIHEE.[1].GISAAEVIMTQLHAGGKFDQQSYKISGGLHGVGVSVVNALSEWLELRIWRNNKEYFIRFNNG     ITE 159  Rickettsia prowazekii ...
ETW21911   87 AMHAS     GIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSIRLEVEIKRDGHEWSQVYEKS     EPM 156  Mycobacterium gastri '...


O67137    158 E.[1].LHVVG.[1].TKKRGTKVSFKPDPEIFE     TTEIKFDIVEKRVRELAYLNPEVKFELTDER.[ 2].KHLI 220  Aquifex aeolicus VF5
P05652    154 T.[1].LEIIG.[1].TDHTGTTTHFVPDPEIFS.[1].TTEYDYDLLANRVRELAFLTKGVNITIEDKR.[ 4].RKNE 219  Bacillus subtilis subs...
P77966    154 G.[1].LEATP.[2].GHSTGTQVSFLPDTQIFK.[1].GIEFDYHTLASRLKELAYLNAGVRITFGDRR.[ 4].KEEQ 220  Synechocystis sp. PCC ...
P43701    156 S.[1].LTVIG.[1].TEATGTTVRFWPSSDIFA     ITTFDYKILAKRLRELSFLNSGVSIRLIDKR.[ 2].SEDH 218  Haemophilus influenzae...
O08399    151 A.[1].VEKRG.[1].SEKRGTIIRWQADPSIFK.[1].TVAYDFDVLLTRLRELAFLNSTVVIQLRDER.[ 4].KQVE 216  Treponema pallidum sub...
P33769    149 S.[1].VEVVG.[1].SSVTGTKVTFLADSEIFE     TLDYNFDVLEKRLKELAFLNDKIYISIEDKR.[ 4].KSSK 213  Borrelia burgdorferi B31
P47249    157 G.[1].LVQEG.[2].EKEHGTIVEFVPDFSVME     KSDYKQTVIVSRLQQLAFLNKGIRIDFVDNR.[ 4].QSFS 222  Mycoplasma genitalium G37
P22447    157 G.[1].LVNEG.[2].DKEHGTKVEFVPDFTVME     KSDYKQTVIASRLQQLAFLNKGIQIDFVDER.[ 4].QSFS 222  Mycoplasma pneumoniae ...
Q9ZCX2    160 A.[1].LSIVK.[2].IDKKGTEVTFFPSVGTFT     NIEFDFVTIEHRLRELAFLNSGVKILLVDNR.[ 4].KKVE 225  Rickettsia prowazekii ...
ETW21911  157 G     LKQGA.[1].TKKTGTTVRFWADPNVFE     TTEYDFETVARRLQEMAFLNKGLTINLTDQR.[34].KKRT 250  Mycobacterium gastri '...


O67137    221 YKFDRGIEELVKYLNEGKEPLFKDIIR     IQGEK.[1].GVIVDIAFQYV     KDYKERIESFVNNIKTVEGGTH 286  Aquifex aeolicus VF5
P05652    220 YHYEGGIKSYVEYLNRSKEVVHEEPIY     IEGEK.[1].GITVEVALQYN     DSYTSNIYSFTNNINTYEGGTH 285  Bacillus subtilis subs...
P77966    221 FYYEGGIREYVTYMTTDKTPLHEEIIY     TSGEK.[1].DVQVEVALQWC.[1].DAYSDTLLGFANNIRTIDGGTH 287  Synechocystis sp. PCC ...
P43701    219 FHYEGGIQAFVEYLNKNKNPIHPKPFY     FTAEK.[1].GIGVEVALQWN     DGVNENVYCFTNNIPQRDGGTH 284  Haemophilus influenzae...
O08399    217 FAFEGGIRHFVSYLNRGKSVVPERPLY     IEGSK.[1].DVLVEVALQYH     DGYTENVQSFVNDINTREGGTH 282  Treponema pallidum sub...
P33769    214 FYFEGGIKSFVDYLTNDSKAFQSEPYY     IDGFI.[1].DVIVNVGLKWT     ESYSDNILSFVNNINTREGGTH 279  Borrelia burgdorferi B31
P47249    223 WKYDGGLVEYIHHLNNEKEPLFNEVIA.[6].VKAVN.[5].TVKVEVAFQYN     KTYNQSIFSFCNNINTTEGGTH 298  Mycoplasma genitalium G37
P22447    223 WKYDGGLVQYIHHLNNEKEPLFEDIIF.[6].VKSVS.[5].TIKVEVAFQYN     KTYNQSIFSFCNNINTTEGGTH 298  Mycoplasma pneumoniae ...
Q9ZCX2    226 FYYTGGIEAYVQYIDRAKHAIHPCIVV     NTVHV.[2].GISLELALHWN     DSYHENILCFTNNIRQRDGGTH 292  Rickettsia prowazekii ...
ETW21911  251 FHYPGGLVDFVKHINRTKNAIHSSIVD     FSGKG.[1].GHEVEIAMQWN     AGYSESVHTFANTINTHEGGTH 316  Mycobacterium gastri '...


O67137    287 VTGFRSGLSKAVIRMAQ     GLKLAK     ELKKSFTGEDVREGLTAVVACKVPNPQFEGQTKTKLGNQNVKQIVES 356  Aquifex aeolicus VF5
P05652    286 EAGFKTGLTRVINDYAR     KKGLIK     ENDPNLSGDDVREGLTAIISIKHPDPQFEGQTKTKLGNSEARTITDT 355  Bacillus subtilis subs...
P77966    288 LEGLKAVLTRTLNSVAR     KRNKLK     DGDSNLGGENIREGLTGVISVKVPDPEFEGQTKTKLGNTEVRGIVDT 357  Synechocystis sp. PCC ...
P43701    285 LAGFRGALTRSLNSYME     NEGMLK     KEKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVES 354  Haemophilus influenzae...
O08399    283 LEGFKSALTRVANDFLK.[1].SPKLAK.[2].EREEKLVGEDVRAGLTVVLSVKIPEPQFEGQTKTKLGNSEVRGIVDS 355  Treponema pallidum sub...
P33769    280 VMGFRSGLTKAMNEAFK     NSKISK     KDIPNLTGDDFKEGLTAVISVKVPEPQFEGQTKSKLGNSEIRKIVEV 349  Borrelia burgdorferi B31
P47249    299 VEGFRNALVKIINRFAV     ENKFLK     DSDEKINRDDVCEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNS 368  Mycoplasma genitalium G37
P22447    299 VEGFRNALVKIINRFAV     ENKFLK     ETDEKITRDDICEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNS 368  Mycoplasma pneumoniae ...
Q9ZCX2    293 LSAFKSAITRVITSYLD     TTGLNK     KTKHDFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPVVEN 362  Rickettsia prowazekii ...
ETW21911  317 EEGFRSALTSVVNKYAK     DRKLLK     DKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQK 386  Mycobacterium gastri '...


O67137    357 ITYDFLTSYFEKKRDVLKAIVEKAIEAALAREAAKKAKELVRRKSPLEEGVLPGKLADCSETDPSKCEIFLVEGDSAGG 435  Aquifex aeolicus VF5
P05652    356 LFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKARELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGG 434  Bacillus subtilis subsp...
P77966    358 LVGEALTEFLEFNPGVADAIIEKAVQAFKAAEAARRARELVRRKSVLESSTLPGKLADCSSKDPSESEIFIVEGDSAGG 436  Synechocystis sp. PCC 6...
P43701    355 AMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYLVEGDSAGG 433  Haemophilus influenzae ...
O08399    356 LVGERLTLYFEQNPGVLTKILEKSIAEAQARLAARRAKEAARRKSGMDSFGLPGKLADCSLKDPAKCEVYIVEGDSAGG 434  Treponema pallidum subs...
P33769    350 VVYEHLLEIINLNPLEIDTILGKAIKAARAREAARKARESERKKNAFESLALPGKLADCTSKNPLEREIYIVEGDSAGG 428  Borrelia burgdorferi B31
P47249    369 VVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGG 447  Mycoplasma genitalium G37
P22447    369 IVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGG 447  Mycoplasma pneumoniae M129
Q9ZCX2    363 AVYTKVLEWFEEHPTEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGG 441  Rickettsia prowazekii s...
ETW21911  387 VCNEQLTHWFEANPADAKTVVNKAVSSAQARIAARKARELVRRKSATDLGGLPGKLADCRSTDPRKSELYVVEGDSAGG 465  Mycobacterium gastri 'W...


O67137    436        SAKQARDRRYQAILPLRGKIINVEKARIDKVLSNDEIKAIVSALGCGI.[1].E.[1].LDLKKLRYHKIILM 500  Aquifex aeolicus VF5
P05652    435        SAKQGRDRHFQAILPLRGKILNVEKARLDKILSNNEVRSMITALGTGI     G.[2].FNLEKARYHKVVIM 499  Bacillus subtilis subs...
P77966    437 .[435].SAKQGRDRRFQAILPLRGKILNIEKTDDAKIYKNTEIQALITALGLGI.[1].G.[2].FDISSLRYHRVVIM 937  Synechocystis sp. PCC ...
P43701    434        SAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGI.[1].R.[2].YNPDKLRYHHIIIM 499  Haemophilus influenzae...
O08399    435        SAKKGRDSKTQAILPLWGKMLNVEKTRLDKVLHNEKLQPIIATLGTGV.[1].K.[1].FDLTRIRYHKVIIM 499  Treponema pallidum sub...
P33769    429        SAKMGRNRFFQAILPLWGKMLNVEKTREDKVITNDKLIPIIASLGAGV.[1].K.[1].FDITKLRYHKIIIM 493  Borrelia burgdorferi B31
P47249    448        TAKTGRDRYFQAILPLRGKILNVEKSNFEQIFNNAEISALVMAIGCGI.[1].P.[1].FELEKLRYSKIVIM 512  Mycoplasma genitalium G37
P22447    448        TAKTGRDRYFQAILPLRGKILNVEKSHFEQIFNNVEISALVMAVGCGI.[1].P.[1].FELEKLRYNKIIIM 512  Mycoplasma pneumoniae ...
Q9ZCX2    442        TAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGISV.[1].R.[1].FSLEKLRYHKVIIM 506  Rickettsia prowazekii ...
ETW21911  466        SAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGI.[1].D.[1].FDIARLRYHKIVLM 530  Mycobacterium gastri '...


O67137    501 TDADVDGSHIRTLLLTFFYRFMPKLVEEGYVYIAEPPLYRVKKGK.[110].D.[63].S     GMEVQRYKGLGEMNP 735  Aquifex aeolicus VF5
P05652    500 TDADVDGAHIRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGK.[  3].Y.[16].T.[1].KPGLQRYKGLGEMNA 581  Bacillus subtilis subs...
P77966    938 TDADVDGAHIRTLLLTFFYRYQRDLVDQGYIYIACPPLYKLERGK.[  3].Y.[16].N.[1].NYTIQRFKGLGEMMP 1019 Synechocystis sp. PCC ...
P43701    500 TDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGK.[ 93].E.[96].K     GLEVQRYKGLGEMNA 750  Haemophilus influenzae...
O08399    500 ADADVDGSHIRTLLLTFFFRYLPQIIEAGYVYLAMPPLYRIAWSK.[  3].Y.[16].K.[1].GVAVQRYKGLGEMDG 581  Treponema pallidum sub...
P33769    494 ADADVDGSHIRTLLLAFFFRYMRDLIENGYIYIAMPPLYKIKYDN.[  3].Y.[19].N     SISLQRYKGLGEMNP 577  Borrelia burgdorferi B31
P47249    513 TDADVDGAHIRTLLLTFFFRFMYPLVEQGNIFIAQPPLYKVSYSH.[  3].Y.[15].N.[1].KFGLQRYKGLGEMDA 593  Mycoplasma genitalium G37
P22447    513 TDADVDGAHIRTLLLTFFFRFMYPLVEQGNIYIAQPPLYKVSYSN.[  3].Y.[15].N.[1].KYNLQRYKGLGEMDA 593  Mycoplasma pneumoniae ...
Q9ZCX2    507 TDADVDGSHIRALLLTFFYRHMPELINKGYLYIAQPPLYKVKSGA.[ 90].D.[92].K     GITIQRFKGLGEMNS 750  Rickettsia prowazekii ...
ETW21911  531 ADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQR.[ 26].N      K     EDGIQRYKGLGEMDA 618  Mycobacterium gastri '...


O67137    736 EQLWETTMNPKTRRLKKVKIEDAAEADRIFTILMGEQVEPRREFIEAY     AKE.[1].K.[1].LDV 792  Aquifex aeolicus VF5
P05652    582 TQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRNFIEAN     ARY.[1].K.[1].LDI 638  Bacillus subtilis subsp. subtili...
P77966   1020 QQLWDTTMNPESRTMKRVHIEDAAEADRIFTVLMGDRVAPRREFIETY.[2].KLD.[1].T.[1].LDI 1078 Synechocystis sp. PCC 6803 subst...
P43701    751 DQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELN     ALR     A.[1].LDV 806  Haemophilus influenzae Rd KW20
O08399    582 TQLWETTMNPVRRKMMQVVLSDAVEADRVFSTLMGEDVEPRRKFIEEN     AIY.[1].R     LDV 637  Treponema pallidum subsp. pallid...
P33769    578 TQLWETTMDPARRKMRLMNIDDAIEAEKIFVTLMGDLVEPRKEFIEQN     ALN.[1].I.[1].LDV 634  Borrelia burgdorferi B31
P47249    594 LQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEKN     ARS.[1].K.[1].IDI 650  Mycoplasma genitalium G37
P22447    594 IQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEQN     ARN.[1].K.[1].IDI 650  Mycoplasma pneumoniae M129
Q9ZCX2    751 DQLWETTLDPTKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQAN     ALN.[1].M.[1].LDV 807  Rickettsia prowazekii str. Madrid E
ETW21911  619 KELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRN     AKD.[1].R.[1].LDV 675  Mycobacterium gastri 'Wayne'
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