Conserved Protein Domain Family

cl12031: Esterase_lipase Superfamily (this model, PSSM-Id:176940 is obsolete)
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Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.
Taxonomy: root
PubMed: 37 links
Protein: Related Protein
Related Structure
Accession: cl12031
PSSM Id: 176940
Name: Esterase_lipase
Created: 20-Jan-2010
Updated: 5-Oct-2010
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