Conserved Protein Domain Family
LDH_MDH_like

?
cd00650: LDH_MDH_like 
Click on image for an interactive view with Cn3D
NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family
Members of this family include ubiquitous enzymes like L-lactate dehydrogenases (LDH), L-2-hydroxyisocaproate dehydrogenases, and some malate dehydrogenases (MDH). LDH catalyzes the last step of glycolysis in which pyruvate is converted to L-lactate. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH/MDH-like proteins are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
?
PSSM-Id: 133419
View PSSM: cd00650
Aligned: 14 rows
Threshold Bit Score: 163.259
Threshold Setting Gi: 31615790
Created: 7-Mar-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
Hierarchy
?
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

cd00650 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00650 is a member of the superfamily cl21454.
cd00300:LDH_likecd00650:LDH_MDH_likecd00704:MDHcd01336:MDH_cytoplasmic_cytosoliccd01337:MDH_glyoxysomal_mitochondrialcd01338:MDH_choloroplast_likecd01339:LDH-like_MDHcd05197:GH4_glycoside_hydrolasescd05290:LDH_3cd05291:HicDH_likecd05292:LDH_2cd05293:LDH_1cd05294:LDH-like_MDH_nadpcd05295:MDH_likecd05296:GH4_P_beta_glucosidasecd05297:GH4_alpha_glucosidase_galactosidasecd05298:GH4_GlvA_pagL_like5MDH A57530355380147712924279315638432572124124198426732245833944868671516751994367466137365636217561064601653766804051748559261183832511454972021461654011183638717819239615077032168051601111335091167880821160580882452807720958634355317991CIV A7MDH B116789369190697391160591215040073089794011BMD A1WZE A122959508840279611B8V A3D5T A6655777516700892612372674515424421574850973118346673145477765567491128909530012299688184027960484282534842824659799810160871967484282521491751551491978391670089421088041291982579911971036181520325821687015741675374891054961123491614419336512350156812347495627733395674829815697139914963298412633800150750308203027441156665391562250191960134161OBB B167039057157364241160901617156432001609023191VJT A206901100150020659154250031206901539126465608119720416159041403179056014026146156741863171059913116248926671536581542523852069005531462965741538896353912990892113321573713422121907611846879220690091756908427118725381140261414691511816093428415038411515389076715381621182946675399334558871261439157601462977332069002111608809791609387661S6Y A1500188481677563261683332922506168210627066156134755207878723099728146321930289015501499082841503918842889940820515323154499580182418063167464823156741370375266471UP7 A1UP4 H15736291420690123216093190413409817521221117167755370162447133116621044211094021184676941529642358449449814827152729828296721631675083915415450790611996049516384044751857277151411761544962001U8X X181438563914017133640972106304748909650837525908150019614139439398210631999210628545160944300597984271609147575696384391224797150019792196247958212696968148378269164149761824174611IB6 A1EMD A11477258824663595198465110195382709198457834195382711195280511954362061951609161954320681984717931951321831953933021543361071MLD A2DFD A50758110508823263141956211565196167466111984345984640628815635042231830742464788116753478226057821SEV B1SMK A11678994316801415611605638011457221907531645879855479014711906840293382115819632100759351700969991646557851492470421903455072115908911268955028666715684342145187709250685050293321451881255031163915684352229826879158993141GUZ A1GV0 B91200102513161791GUY A324454921720442989496897818921938414285576206889307124514199513161415131618151316163189081586942657485131617212316326710989261017089697392099673920995898963301583177121098925992099040981670317122D4A A513161821890815821185767561LDG A1OC4 A2A92 A1PZH D1SOV A259896371560872801942474961245132722FM3 A2HJR A4961750551316176513161841521405616623321651316159109892591196019168148285005513161561098925821890816027392098410989259814285573188996564513161955131616678777246152992167345574471662332081577375582070852971HYE A5131614915040104138604674513161401098925961HLP A1OJU A49035986490360925084150650843401382330411245236597249407328900002887978381EZ4 A1LLC A169809391382578631339304912933660012227591513393047749036047490360931164941846844625050428371382578482126964411153122098182727611000451849035982134642553987585816970841736762033860171718512611LDN A818220531260591720569071876055851609157041624478821646883508431619517368748173674761HYH C2501020155822614283780141185873161841550662837726728378926909625694251961716800843786096991394387022127151631579249149036041169185196490360891463116552421185515001971116087926618241911115001888415001764116871575316774898815448459016776741816087938166850813169614690173693621I0Z A5LDH A692006811707321I10 A1V6A A2V65 A2LDX A289520024976221159587422497623310444982865462168051701156555298665119952I6T A11809128376779532504171324555042219846013119543197319475771019538818019538158911075842632472038182413118324711151LLD A50842374116672520184200147162453521145220911490359761590261331Y6J A17367757399696878511360923821816166223148153954006182417189145559490490359771462960618921069117204434314767708216763079711531220816983167515450350421063276416777097794968511163847238490359752069000982V6B A1932160791106008022V6M A2E37 C209966761163759686211960008116256321209904596490359721A5Z A1890464251717694301669877452130133915MDH A57530355380147712924279315638432572124124198426732245833944868671516751994367466137365636217561064601653766804051748559261183832511454972021461654011183638717819239615077032168051601111335091167880821160580882452807720958634355317991CIV A7MDH B116789369190697391160591215040073089794011BMD A1WZE A122959508840279611B8V A3D5T A6655777516700892612372674515424421574850973118346673145477765567491128909530012299688184027960484282534842824659799810160871967484282521491751551491978391670089421088041291982579911971036181520325821687015741675374891054961123491614419336512350156812347495627733395674829815697139914963298412633800150750308203027441156665391562250191960134161OBB B167039057157364241160901617156432001609023191VJT A206901100150020659154250031206901539126465608119720416159041403179056014026146156741863171059913116248926671536581542523852069005531462965741538896353912990892113321573713422121907611846879220690091756908427118725381140261414691511816093428415038411515389076715381621182946675399334558871261439157601462977332069002111608809791609387661S6Y A1500188481677563261683332922506168210627066156134755207878723099728146321930289015501499082841503918842889940820515323154499580182418063167464823156741370375266471UP7 A1UP4 H15736291420690123216093190413409817521221117167755370162447133116621044211094021184676941529642358449449814827152729828296721631675083915415450790611996049516384044751857277151411761544962001U8X X181438563914017133640972106304748909650837525908150019614139439398210631999210628545160944300597984271609147575696384391224797150019792196247958212696968148378269164149761824174611IB6 A1EMD A11477258824663595198465110195382709198457834195382711195280511954362061951609161954320681984717931951321831953933021543361071MLD A2DFD A50758110508823263141956211565196167466111984345984640628815635042231830742464788116753478226057821SEV B1SMK A11678994316801415611605638011457221907531645879855479014711906840293382115819632100759351700969991646557851492470421903455072115908911268955028666715684342145187709250685050293321451881255031163915684352229826879158993141GUZ A1GV0 B91200102513161791GUY A324454921720442989496897818921938414285576206889307124514199513161415131618151316163189081586942657485131617212316326710989261017089697392099673920995898963301583177121098925992099040981670317122D4A A513161821890815821185767561LDG A1OC4 A2A92 A1PZH D1SOV A259896371560872801942474961245132722FM3 A2HJR A4961750551316176513161841521405616623321651316159109892591196019168148285005513161561098925821890816027392098410989259814285573188996564513161955131616678777246152992167345574471662332081577375582070852971HYE A5131614915040104138604674513161401098925961HLP A1OJU A49035986490360925084150650843401382330411245236597249407328900002887978381EZ4 A1LLC A169809391382578631339304912933660012227591513393047749036047490360931164941846844625050428371382578482126964411153122098182727611000451849035982134642553987585816970841736762033860171718512611LDN A818220531260591720569071876055851609157041624478821646883508431619517368748173674761HYH C2501020155822614283780141185873161841550662837726728378926909625694251961716800843786096991394387022127151631579249149036041169185196490360891463116552421185515001971116087926618241911115001888415001764116871575316774898815448459016776741816087938166850813169614690173693621I0Z A5LDH A692006811707321I10 A1V6A A2V65 A2LDX A289520024976221159587422497623310444982865462168051701156555298665119952I6T A11809128376779532504171324555042219846013119543197319475771019538818019538158911075842632472038182413118324711151LLD A50842374116672520184200147162453521145220911490359761590261331Y6J A17367757399696878511360923821816166223148153954006182417189145559490490359771462960618921069117204434314767708216763079711531220816983167515450350421063276416777097794968511163847238490359752069000982V6B A1932160791106008022V6M A2E37 C209966761163759686211960008116256321209904596490359721A5Z A189046425171769430166987745213013391
cd00650 Sequence Cluster
cd00650 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
CD Hierarchy
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                  ##     #                    ##                                       
1I0Z_A       23 ITVVGV     GQ     VGMACAISIL.[ 6].ELALVDVL.[2].KLKGEMMDLQHGS.[6].KIVADK.[1].YSVT 86
5MDH_A        6 VLVTGA.[1].GQ     IAYSLLYSIG.[11].ILVLLDIT.[4].VLDGVLMELQDCA.[5].DVIATD.[2].EIAF 77
1GUZ_A        3 ITVIGA     GN     VGATTAFRLA.[ 6].ELVLLDVV.[2].IPQGKALDMYESG.[7].KVTGSN.[1].YADT 67
1IB6_A        3 VAVLGA.[1].GG     IGQALALLLK.[ 7].ELSLYDIA.[1].VTPGVAVDLSHIP.[3].KIKGFS.[4].TPAL 67
1OBB_B        6 IGIIGA.[1].SA.[1].FSLRLVSDLC.[ 8].TVTLMDID.[2].RLDAILTIAKKYV.[7].KFEKTM.[2].DDVI 75
1S6Y_A       10 IATIGG.[1].SS     YTPELVEGLI.[ 9].ELWLVDIP.[4].KLEIVGALAKRXV.[7].EIHLTL.[2].RRAL 81
1U8X_X       31 IVIAGG.[1].ST     FTPGIVLXLL.[ 9].KLKLYDND.[2].RQDRIAGACDVFI.[7].EFAATT.[2].EEAF 100
1UP7_A        5 IAVIGG.[1].SS     YTPELVKGLL.[ 9].EVIFYDID.[2].KQKIVVDFVKRLV.[4].KVLISD.[2].EGAV 71
1Y6J_A       10 VAIIGA     GF     VGASAAFTMA.[ 6].ELVLIDVF.[2].KAIGEAMDINHGL.[5].MSLYAG.[1].YSDV 72
gi 49035986   7 IVVIGA     SN     VGSAVANKIA.[ 6].EVVLIDLN.[2].KAWGEAKDSSHAT.[8].KFHLGD     YEDC 71

Feature 1               ##                 #                     ###                    #      #
1I0Z_A       87 ANSKIVVVTA.[12].LVQRNV.[1].VFKFIIPQIVK.[3].DCIIIVVSNPVDILTYVT.[ 8].HRVIGSG.[2].L 165
5MDH_A       78 KDLDVAILVG.[12].LLKANV.[1].IFKCQGAALDK.[4].SVKVIVVGNPANTNCLTA.[ 9].ENFSCLT.[1].L 157
1GUZ_A       68 ANSDIVIITA.[12].LLMKNA.[1].IVKEVTDNIMK.[3].NPIIIVVSNPLDIMTHVA.[ 8].ERVIGMA.[2].L 146
1IB6_A       68 EGADVVLISA.[12].LFNVNA.[1].IVKNLVQQVAK.[3].KACIGIITNPVNTTVAIA.[12].NKLFGVT.[1].L 149
1OBB_B       76 IDADFVINTA.[38].SNYNQL.[1].YFVDIARKIEK.[3].KAWYLQAANPIFEGTTLV.[ 5].IKAVGFX     H 175
1S6Y_A       82 DGADFVTTQF.[32].KGLRTI.[1].VILDIIRDXEE.[3].DAWLINFTNPAGXVTEAV.[ 6].EKVVGLC     N 176
1U8X_X      101 TDVDFVXAHI.[32].YGXRSI.[1].GVLEILDYXEK.[3].DAWXLNYSNPAAIVAEAT.[ 6].SKILNIC     D 195
1UP7_A       72 VDAKYVIFQF.[32].AALRAF.[1].IVEEYVDTVRK.[2].NATIVNFTNPSGHITEFV.[ 6].EKFIGLC     N 165
1Y6J_A       73 KDCDVIVVTA.[12].LAKKNV.[1].IAKEVTQNIMK.[3].HGVILVVSNPVDIITYMI.[ 8].GKVIGSG.[2].L 151
gi 49035986  72 KDANIIVITA.[14].LAGTNA.[1].IMSSVMGEIVK.[3].EAMIIMITNPLDVATYVV.[ 8].NLILGTG.[2].L 152

Feature 1                                       #                          #                    
1I0Z_A      166 DSARFRYLMAEKL.[5].SCH     GWILGEHGD.[2].VAVW.[1].GVN.[ 46].IGLSVADLIESML.[4].RIH 271
5MDH_A      158 DHNRAKAQIALKL.[5].DVK.[1].VIIWGNHSS.[2].YPDV.[1].HAK.[ 46].AAKAICDHVRDIW.[6].EFV 266
1GUZ_A      147 DAARFRSFIAMEL.[5].DIN     ACVLGGHGD.[2].VPVV.[1].YTT.[ 41].PASSVVEMVESIV.[4].RVL 247
1IB6_A      150 DIICSNTFVAELK.[5].EVE     VPVIGGHSG.[3].LPLL.[1].QVP.[ 36].MGQAAARFGLSLV.[8].VVE 250
1OBB_B      176 GHYGVMEIVEKLG.[4].KVD     WQVAGVNHG     IWLN     RFR.[140].SGEQHIPFIDALL.[4].ARF 371
1S6Y_A      177 VPIGXRXGVAKLL.[5].RVH     IDFAGLNHX     VFGL     HVY.[105].YSDAACSLISSIY.[4].DIQ 338
1U8X_X      196 XPVGIEDRXAQIL.[6].EXK     VRYYGLNHF     GWWT     SIQ.[109].HASYIVDLARAIA.[4].ERX 362
1UP7_A      166 VPINFIREIAEMF.[5].DVF     LKYYGLNHL     SFIE     KVF.[ 93].YSTAAAHLIRDLE.[4].KIH 315
1Y6J_A      152 DSIRFRYLLSEKL.[5].NVH     GYIIGEHGD.[2].LPLW.[1].CTH.[ 46].IAVSINTIVETLL.[4].TIR 257
gi 49035986 153 ETYRFRRILADKY.[5].NIN     GYVLGEHGN.[2].FVAW.[1].TTG.[ 45].IAMAACRFIKSVL.[4].TIL 257

Feature 1                                                                       
1I0Z_A      272 PVSTMVK.[8].VFLSLPCILNARG.[3].VIN     QKL.[2].DEVAQLKKSADTLWDIQK 328
5MDH_A      267 SMGIISD.[9].LLYSFPVTIKDKT.[2].IVE.[1].LPI.[2].FSREKMDLTAKELAEEKE 324
1GUZ_A      248 PCAVGLE.[7].TFVGVPVKLGRNG.[3].IYE     INL.[2].ADLDLLQKSAKIVDENCK 303
1IB6_A      251 CAYVEGD.[4].RFFSQPLLLGKNG.[3].RKS.[1].GTL.[2].FEQNALEGMLDTLKKDIA 304
1OBB_B      372 VVNIPNK.[9].VVVEVPALVDKNG.[2].PEK.[1].EPP.[4].VVKYYLRPRIMRMEMALE 431
1S6Y_A      339 PVNTRNN.[9].SAVEVNCVITKDG.[2].PIA     VGD.[3].AVRGLVQQIKSFERVAAE 396
1U8X_X      363 LLIVENN.[9].AXVEVPCIVGSNG.[2].PIT     VGT.[3].FQKGLXEQQVSVEKLTVE 420
1UP7_A      316 IVNTRNN.[9].YVLEIPCYVRSGR.[2].TLS     QGK.[3].FALSFIHAVKMYERLTIE 373
1Y6J_A      258 TVGTVIN.[7].VAISLPSIVNSEG.[3].VLQ     FNL.[2].EEEEALRFSAEQVKKVLN 313
gi 49035986 258 PCSAVLE.[7].VALSIPRMVCADG.[3].SFE     VHL.[2].DELEKMHKAAQSVRSALD 313

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap