Conserved Protein Domain Family
RING-HC_ScRAD18-like
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cd23148: RING-HC_ScRAD18-like 
RING finger, HC subclass, found in Saccharomyces cerevisiae radiation sensitivity protein 18 (RAD18) and similar proteins
RAD18, also called RING-type E3 ubiquitin transferase RAD18, acts as a postreplication repair E3 ubiquitin-protein ligase that associates with the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. RAD18 is an E3 RING-finger protein belonging to the UBC2/RAD6 epistasis group. It contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438510
Aligned: 5 rows
Threshold Bit Score: 94.1372
Created: 17-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #           # #  #  #             #  #         
P10862        23 DTLLRCHICKDFLKvPVLTPCGHTFCSLCIRTHLn---nQPNCPLCLFEFRESLL 74  Saccharomyces cerevisiae S288c
XP_014153862 666 QHAITCSICLSLLQaPMKTPCNHRFCKFCIATHLn---nQASCPLCKGPVTKRSL 717 Sphaeroforma arctica JP610
Q5A4N5        24 DILKRCYICKDLLNaPVRTQCDHTYCSQCIREFLl---rDNRCPLCKTEVFESGL 75  Candida albicans SC5314
P33288        29 EQAFRCHVCKDFYDsPMLTSCNHTFCSLCIRRCLs---vDSKCPLCRATDQESKL 80  Neurospora crassa OR74A
XP_004998238  12 SKALECGICKDVLKqPQRTRCNHVYCKFCILKHLelsksKCRCPLCKADLTKRGL 66  Salpingoeca rosetta

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