Conserved Protein Domain Family
RING-HC_AtBRCA1-like
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cd23147: RING-HC_AtBRCA1-like 
RING finger, HC subclass, found in Arabidopsis thaliana protein BREAST CANCER SUSCEPTIBILITY 1 homolog (AtBRCA1) and similar proteins
AtBRCA1 plays a role in DNA repair and in cell-cycle control. It is required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR). AtBRCA1 contains a typical C3HC4-type RING-HC finger.
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Statistics
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PSSM-Id: 438509
Aligned: 4 rows
Threshold Bit Score: 105.243
Created: 17-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #           # #  #  #          #  #          
Q8RXD4      10 MGRELKCPICLSLYNSAVSLSCNHVFCNACIVKSMKmdaTCPVCKIPYHRREIR 63   thale cress
EFJ24465     8 FGRELKCPICLSLFQQAAVLSCTHCFCKPCILTSLKgmpFCPVCKVPATRREVR 61   Selaginella moellendorffii
GAQ82577     9 LGKELTCPICLGLLKSAVHLACNHCFCRGCIQQSILtkaSCPVCKKPAHKRDLR 62   Klebsormidium nitens
GBG63723    33 LGKMLSCPICLQLFKTAANLPCGHTFCAGCLGESLMlssICPVCHIHATAEDTR 86   Chara braunii

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