Conserved Protein Domain Family
RING-HC_SPL2-like
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cd23145: RING-HC_SPL2-like 
RING finger, HC subclass, found in Arabidopsis thaliana SP1-like protein 2 (SPL2) and similar proteins
SPL2, also known as RING-type E3 ubiquitin transferase SPL2, acts as an E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination. SPL2 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438507
Aligned: 4 rows
Threshold Bit Score: 54.8994
Created: 17-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #           # #   #  #              #  #  
Q9SYH3       326 PDGELCVICVSRRRvpAFIPCGHVVCCRRCASTVere---lnpKCPVCLQ 372 thale cress
XP_003061630  75 APGETCVVCLYEAAsvVYKECGHLVCCELCARRMt--------RCPLCRR 116 Micromonas pusilla CCMP1545
XP_002990636 330 PDGQLCVVCLLRRKraAFITCGHRVCCMGCARRIrhsqnaanaRCPVCRQ 379 Selaginella moellendorffii
XP_024398249 402 PEGELCVVCLLRRRrsAFIHCGHRVCCIVCARRVqqg---adpRCPVCRQ 448 Physcomitrium patens

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