Conserved Protein Domain Family
RING-HC_CeBARD1-like
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cd23143: RING-HC_CeBARD1-like 
RING finger, HC subclass, found in Caenorhabditis elegans BRCA1-associated RING domain protein 1 (CeBARD1) and similar proteins
CeBARD1, also called Ce-BRD-1, Cebrd-1, or RING-type E3 ubiquitin transferase BARD1, is a constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. It plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation. It protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability. CeBARD1 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438505
Aligned: 5 rows
Threshold Bit Score: 75.2741
Created: 17-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #                     # #  #  #                   #  #     
Q21209         15 AIECVKCKKPRGdl--------qYLGSSCKHAYCWECIATFQqkpsgkrssvaRHMCPSCAFPLD 71   Caenorhabditis elegans
A0BG98        974 ITECLICTKSQIs---------vFSLSSCGHIYCKECFGETVv---------kLKNCPSCRTKLT 1020 Paramecium tetraurelia
XP_001435117  969 LQECEICTNTQVd---------tFCLSSCGHIFCRKCFTQAIn---------qQQLCPVCRATLS 1015 Paramecium tetraurelia strai...
XP_001461589  981 LNDCTLCSEDGIt---------tFDISICGHVYCHNCFKEVIe---------tIGECPTCSKRLS 1027 Paramecium tetraurelia strai...
Q554L2          6 FLECSICSEEVIdfaaifssnkkFGDKACKHNFCVSCLTYLMeynt---rnkkALCCPICREEFD 67   Dictyostelium discoideum AX4

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