Conserved Protein Domain Family
RING-HC_CHR27-like
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cd23142: RING-HC_CHR27-like 
RING finger, HC subclass, found in Arabidopsis thaliana protein CHROMATIN REMODELING 27 (CHR27) and similar proteins
CHR27, also called protein SNF2-RING-HELICASE-LIKE 1, is a probable helicase-like transcription factor involved in transcriptional gene silencing. It associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. It may be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin. It associates with SUVR2 and functions redundantly with FRG2. It is required for the efficient methylation of a broad range of RdDM target loci. CHR27 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438504
Aligned: 5 rows
Threshold Bit Score: 84.5451
Created: 15-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #           # #  #  #                    #    #         
Q9LHE4        749 AICYECNEPPEKPVVTLCGHIFCYECVLEYITGde---------nTCPVprCKQQLARDVV 800  thale cress
PSC70181      952 EPCAVCADVPEDAVVAVCSHVFCAQCVATELSNaghgaaevelafHCPT--CRQELGKHDI 1010 Micractinium conductrix
P40072        204 YRCPICFEPPETALMTLCGHVFCCPCLFQMVNSsrtc----rqfgHCAL--CRSKVYLKDV 258  Saccharomyces cerevisiae S288c
NP_001117525  826 AICGICNDAPEDAVASVCGHVFCKQCIYERLTGds---------nHCPFanCNVRLTISSL 877  thale cress
XP_023461008  597 LVCMLCNDPPEDAISAACKHVFCRECCIQYYSSfddse---gevpKCPS--CFANFSVDLS 652

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