Conserved Protein Domain Family
RING-HC_ARI6-like
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cd23141: RING-HC_ARI6-like 
RING finger, HC subclass, found in Arabidopsis thaliana protein ariadne homolog 6 (ARI6) and similar proteins
This subfamily includes ARI6 and ARI11. They might act as E3 ubiquitin-protein ligases, or as part of E3 complexes, which accept ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfer it to substrates. Members of this subfamily contain a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438503
Aligned: 7 rows
Threshold Bit Score: 112.195
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #             # #  #  #                   #    #        
P0C8K8    130 EFTCGICFESYpleETISVSCGHPFCATCWTGYISTSInDGPGCLMLKCPYPCCPAAIGRDM 191 thale cress
EFJ17699  131 EIVCGICFDAFgvdKMRATVCGHYFCSLCWTGYVHTAIsDGPGCLTLRCPDPSCNAAVGDEL 192 Selaginella moellendorffii
CEF99681  164 TTTCNICFDDFepsELVTAGCSHAFCTGCWAGYIASKIgEGLSVVDTRCPMTKCPIKVGEAM 225 Ostreococcus tauri
PSC75961  125 EETCKICFESYavaDMAAARCKHYYCKDCWRGYVHNAVqSGPSCLDLRCPDPECKAAVPRSV 186 Micractinium conductrix
PNR49681  138 EMTCGICFEGHpfeKMTAPRCGHYFCETCWTGYIHTAInDGPGCLTLRCADPSCGAAVGEDM 199 Physcomitrium patens
PNW72103  128 EERCFICFDSFpvrDMRSAACRHYFCKDCWRGYITQALsSGPACLDLRCPSTECKQKACVPC 189 Chlamydomonas reinhardtii
Q9SKC2    136 DIQCGICFESYtrkEIARVSCGHPYCKTCWTGYITTKIeDGPGCLRVKCPEPSCYAVVGQDM 197 thale cress

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