Conserved Protein Domain Family
RING-HC_TRY3-like

cd23137: RING-HC_TRY3-like

RING finger, HC subclass, found in Candida albicans transcriptional regulator of yeast form adherence 3 (TRY3) and similar proteins

TRY3 acts as a transcription factor required for yeast cell adherence to silicone substrate. It contains a typical C3HC4-type RING-HC finger.

Links

Source:	cd16449
Taxonomy:	Fungi
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl17238

Statistics

PSSM-Id:	438499
Aligned:	7 rows
Threshold Bit Score:	99.0791
Created:	11-Jun-2021
Updated:	17-Oct-2022

Structure

Conserved Features/Sites?
PubMed References ?

Zn binding site

Feature 1: Zn binding site [ion binding site], 8 residue positions

Conserved feature residue pattern:C C C H C C C C

Click to see conserved feature residue pattern help

Evidence:

Comment:based on the structures of other RING-HC fingers with bound zinc
Citation:PMID 11573085
Citation:PMID 22589545
Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1          #  #           # #  #  #           #  #          
Q5A1M4     394 DDYSCPICMNIAYKPIRLSCGHLFCVRCLVKMkqdDKTSCPLCRKENAILYAD 446  Candida albicans SC5314
O14212     370 RDFECAICSNVAYKPVRLGCSHVFCLHCLIILqkqKVDFCPLCRAKEVMKADS 422  Schizosaccharomyces pombe 972h-
CCF51972   681 DDYSCAICTSVAWRPVRLDCSHLFCLRCLVKLqrqGKDDCPLCRAPGVVKSAD 733  Ustilago hordei
POS76633   375 DDYTCPICFSIAWYPVRLRCSHIFCVRCVIKMqrdKKKQCPLCRDEVVMEADL 427  Diaporthe helianthi
CEG71926   355 EDYACPVCMCVAWRPIRLECNHVFCVRCLVKAqkqKMDSCPMCRHPTAVRDAT 407  Rhizopus microsporus
ORY40896   901 EKYACPICQELAYKPIRLDCGHLFCLKCLIKAqkkNLDNCPVCRSKDAVKNAT 953  Neocallimastix californiae
ORX73729   383 DDYLCPMCLNVAWRPLRLECNHVFCSRCVVKAsrrRMFNCPVCRAKGAIYRAG 435  Linderina pennispora

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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Conserved Protein Domain FamilyRING-HC_TRY3-like

Conserved Protein Domain Family
RING-HC_TRY3-like