Conserved Protein Domain Family
RING-HC_ULS1-like
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cd23136: RING-HC_ULS1-like 
RING finger, HC subclass, found in Saccharomyces cerevisiae ubiquitin ligase for SUMO conjugates protein 1 (ULS1) and similar proteins
ULS1, also called role in silencing protein 1, is an ATP-dependent helicase involved in mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. It cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates. ULS1 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438498
Aligned: 13 rows
Threshold Bit Score: 118.567
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #               # #  #  #                           #  #               
Q08562       1324 SMNSMTCFWCMEQLEPEAMs-VLTGCGHLICDTCIEPFIEEssmlpq--akktkGGAFAIPCKDCQRLTNEKDIVSHKLY 1400 Saccharomyces...
PIS51928      403 SDAQLTCPMCFDVVDSSSIv-ILHPCGHMICDGCVDSLFEQe-----------gNEDGSVPCNTCRQSITEDALISYVVY 470  [Candida] auris
SGZ53029      827 NEVQFTCPMCFDVVGEKSIv-IFGTCGHLICDGCVDNFFEQyrte------sseYGNREASCNTCTAKVTNSSLVDYYFY 899  [Candida] int...
SCU81422     1022 GLENMTCPYCMEQMELDSAv-VITPCGHMLCDGCADQYFEDirsqgn--trkivNSGYAVPCLVCNRIVDDNAVVTYKLY 1098 Lachancea sp....
QBM90111      920 QDIQFTCPLCFDVVGEGSIk-ILAACGHMVCDGCVDTLFSAnd---------qgLRTQSAHCVTCGERAALTDIVDYVLF 989  Metschnikowia...
RKP32255      457 DDVLLACPLCLDVVGEDMIs-ILAGCGHMICNNCVSNLFESteeg-----vvlgVRASTTPCMTCQKPVSEAQVVPYPVY 530  Metschnikowia...
OVF08367      849 SEIQLTCPICLDVVGSESIl-IFAGCGHMICDGCSLSFFEQqeie------nesTASDKACCMTCHHDVAVADLIEFPLY 921  Clavispora lu...
XP_020078193  883 DESLFTCPVCYDIVSYESVv-LFANCGHVICSGCIDKFFEEndds-----dgaiDGKRSASCLTCNKRVKENELIDYNVF 956  Hyphopichia b...
XP_460608     867 DEDLFTCPICYDVLGYESIv-LFSGCGHMICNNCIENFFERfetg------dgsEGNRLASCFSCSKSIKENELIDYNMF 939  Debaryomyces ...
SCU82750      999 GLDSMMCPYCMEQMEPESTs-ILTPCGHLICESCVEPFMDDarfet---egwkpNDELVVPCLVCKADVSEKAVITYRLY 1074 Lachancea mir...
GEQ72628     1159 SNVQFTCPKCFDVVGEDSIv-ILANCGHMVCDGCVENIFNEtee--------vdTKNPTCKCVSCGAKTGRPDLVKYGLF 1229 Metschnikowia...
XP_002545340  861 EDDTISCPVCFDALDFESSilIFGECGHMICKTCGPSFFEEqdd-------denSKNRSGECKDCKKTVKEQNLMEYILF 933  Candida tropi...
NP_982690    1279 SLENMICPFCMEQMEIESLs-VLTPCGHLLCDACVEPYLEDareseyarkgpkgTRSTFVPCLVCEKLINDHEIISYQLY 1357 Eremothecium ...

Feature 1            
Q08562       1401 DQV 1403 Saccharomyces cerevisiae S288c
PIS51928      471 NQV 473  [Candida] auris
SGZ53029      900 LLM 902  [Candida] intermedia
SCU81422     1099 DQA 1101 Lachancea sp. CBS 6924
QBM90111      990 TKV 992  Metschnikowia aff. pulcherrima
RKP32255      531 DKI 533  Metschnikowia bicuspidata
OVF08367      922 QKV 924  Clavispora lusitaniae
XP_020078193  957 HLV 959  Hyphopichia burtonii NRRL Y-1933
XP_460608     940 HMI 942  Debaryomyces hansenii CBS767
SCU82750     1075 DQI 1077 Lachancea mirantina
GEQ72628     1230 SKI 1232 Metschnikowia sp. JCM 33374
XP_002545340  934 KKI 936  Candida tropicalis MYA-3404
NP_982690    1358 HQA 1360 Eremothecium gossypii ATCC 10895

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