Conserved Protein Domain Family
RING-HC_IRC20-like
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cd23135: RING-HC_IRC20-like 
RING finger, HC subclass, found in Saccharomyces cerevisiae increased recombination centers protein 20 (IRC20) and similar proteins
IRC20 is an uncharacterized ATP-dependent helicase that is probably involved in a pathway contributing to genomic integrity. IRC20 contains a typical C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438497
Aligned: 5 rows
Threshold Bit Score: 74.8594
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #            # #  #  #                #  # 
Q06554    1234 NQILSCSICLGEVei-gAIIKCGHYFCKSCILTWLRa------HSKCPICK 1277 Saccharomyces cerevisiae S288c
SSD61444  1263 GKKFKCSICFGSIkl-gAILKCGHFFCQECAESWLRh------HSTCPMCK 1306 Saccharomycodes ludwigii
SCU78645  1154 DQKFNCTICFSEIym-gTIIKCGHFFCRTCIHSWLRn------KSACPLCK 1197 Lachancea mirantina
NP_176889  295 PAQVSCIICWTEFsssrGILPCGHRFCYSCIQKWADrlvserkKTTCPLCK 345  thale cress
GBG34471   107 KSDLSCSVCFSAMrs-pISLQCGHSFCLACIAPWLKe------KTSCPVCR 150  Hondaea fermentalgiana

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